INT42145

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Context Info
Confidence 0.13
First Reported 1984
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.55
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
plasma 2
coronary artery 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 35 96.12 Very High Very High Very High
Pain 1 85.08 High High
bradykinin 1 81.96 Quite High
cytokine 31 77.40 Quite High
Calcitonin gene-related peptide 1 43.44 Quite Low
qutenza 1 38.80 Quite Low
Angina 1 33.24 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 1 99.92 Very High Very High Very High
Disseminated Intravascular Coagulation 38 99.38 Very High Very High Very High
INFLAMMATION 36 96.12 Very High Very High Very High
Pain 1 85.08 High High
Increased Venous Pressure Under Development 2 83.36 Quite High
Infection 12 82.88 Quite High
Bacterial Infection 1 72.48 Quite High
Sepsis 28 68.64 Quite High
Disease 8 62.72 Quite High
Injury 8 41.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By preventing excess fibrin accumulation in inflamed tissues, the plasminogen activation system also governs the proper evolution of the inflammatory exudates and prevents the possibility of a shift from acute to chronic inflammation.
Negative_regulation (preventing) of Positive_regulation (accumulation) of fibrin associated with inflammation
1) Confidence 0.13 Published 2008 Journal Front. Biosci. Section Abstract Doc Link 18508538 Disease Relevance 0.71 Pain Relevance 0.36
However, their map does not include a number of other proteins that we found to decrease after LPS priming, like coagulation factor XIII and ras suppressor protein.
Negative_regulation (decrease) of Positive_regulation (coagulation) of factor XIII
2) Confidence 0.06 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.16 Pain Relevance 0.08
Heparin-bonded catheters will facilitate investigation of the role of intravascular coagulation in coronary artery disease by eliminating catheter-induced fibrin formation and platelet activation.
Negative_regulation (eliminating) of Positive_regulation (catheter-induced) of fibrin in coronary artery associated with coronary artery disease and disseminated intravascular coagulation
3) Confidence 0.01 Published 1984 Journal Circulation Section Abstract Doc Link 6237807 Disease Relevance 0.20 Pain Relevance 0
It was previously shown antithrombin–heparin treatment significantly attenuated the endotoxin-induced consumption of fibrinogen and completely prevented the increase in soluble fibrin in plasma; however, no significant effect of antithrombin III-heparin was observed on endotoxin-induced mortality and dysfunction in pulmonary gas exchange.
Negative_regulation (prevented) of Positive_regulation (increase) of fibrin in plasma
4) Confidence 0.01 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.48 Pain Relevance 0.10

General Comments

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