INT42152

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Context Info
Confidence 0.66
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.13
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Dsp) protein binding, bridging (Dsp)
Anatomy Link Frequency
nerve 1
brain 1
Dsp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 6 98.96 Very High Very High Very High
noradrenaline 28 98.84 Very High Very High Very High
Dopamine 4 98.12 Very High Very High Very High
alcohol 1 96.16 Very High Very High Very High
Desipramine 4 95.16 Very High Very High Very High
Pain 6 77.68 Quite High
abdominal pain 4 77.12 Quite High
Catecholamine 2 61.84 Quite High
Paracetamol 8 50.00 Quite Low
Analgesic 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Shellfish Poisoning 40 100.00 Very High Very High Very High
Neuropathy 17 100.00 Very High Very High Very High
Sprains And Strains 32 99.02 Very High Very High Very High
Urological Neuroanatomy 4 96.36 Very High Very High Very High
Mycobacterial Infection 4 95.64 Very High Very High Very High
Neuropathic Pain 1 87.24 High High
Peripheral Neuropathy 1 80.08 Quite High
Diarrhoea 4 79.60 Quite High
Vomiting 8 78.80 Quite High
Pain 4 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant increase in the proportion of aspirin DSP presentations for the toxicology service (RR, 3.33; 95% CI, 0.97-11.4; P = 0.043), but no significant changes in paracetamol and ibuprofen DSP presentations.
Gene_expression (presentations) of DSP
1) Confidence 0.66 Published 2002 Journal Med. J. Aust. Section Body Doc Link 11913916 Disease Relevance 0.06 Pain Relevance 0
There was a significant increase in the proportion of aspirin DSP presentations for the toxicology service (RR, 3.33; 95% CI, 0.97-11.4; P = 0.043), but no significant changes in paracetamol and ibuprofen DSP presentations.
Gene_expression (presentations) of DSP
2) Confidence 0.58 Published 2002 Journal Med. J. Aust. Section Body Doc Link 11913916 Disease Relevance 0.05 Pain Relevance 0
RESULTS: The patients had similar baseline characteristics for pain intensity, HbA(1c), and duration of DSP.
Gene_expression (duration) of DSP
3) Confidence 0.58 Published 2004 Journal Diabetes Care Section Body Doc Link 15047649 Disease Relevance 0.30 Pain Relevance 0
Approximately half (49%) of the study population were diagnosed with DSP, and 30% of the study population were diagnosed with SDSP.
Gene_expression (diagnosed) of DSP associated with neuropathy
4) Confidence 0.51 Published 2010 Journal Muscle Nerve Section Abstract Doc Link 20229576 Disease Relevance 1.89 Pain Relevance 0.13
These results are all consistent with the view that DSP4 produces an acute and selective degeneration of central noradrenaline nerve terminals.
Gene_expression (produces) of DSP4 in nerve associated with noradrenaline
5) Confidence 0.34 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6237924 Disease Relevance 0.09 Pain Relevance 0.70
Inhibition of monoamine oxidase, and/or 1-dopa administration 1 week after DSP4 produced very small changes in brain noradrenaline and dopamine levels.
Gene_expression (produced) of DSP4 in brain associated with dopamine, noradrenaline and monoamine
6) Confidence 0.27 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6237924 Disease Relevance 0.10 Pain Relevance 0.62
Additionally, some strains of Roseobacter algicola have been implicated in DSP toxin production [43].
Gene_expression (production) of DSP toxin associated with shellfish poisoning and sprains and strains
7) Confidence 0.10 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525486 Disease Relevance 0.40 Pain Relevance 0
Most interesting, perhaps, is the identification of endosymbiotic bacteria in cells of the DSP toxin producing dinoflagellate, Dinophysis acuminata [35].
Gene_expression (producing) of DSP toxin associated with shellfish poisoning
8) Confidence 0.10 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525486 Disease Relevance 0.10 Pain Relevance 0
Nonetheless, neither P. rhathymum nor P. mexicanum have been reported to produce DSP toxins.
Gene_expression (produce) of DSP associated with shellfish poisoning
9) Confidence 0.10 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525486 Disease Relevance 0.39 Pain Relevance 0
The genus is possibly best known for the production of the diarrheic shellfish poisoning (DSP) class of toxins which include okadaic (OA) acid and the dinophysistoxins (DTX) (Figure 1) [1].
Gene_expression (production) of DSP associated with shellfish poisoning
10) Confidence 0.07 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525486 Disease Relevance 0.75 Pain Relevance 0.08

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