INT4216

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Context Info
Confidence 0.78
First Reported 1976
Last Reported 2011
Negated 35
Speculated 10
Reported most in Abstract
Documents 328
Total Number 338
Disease Relevance 256.02
Pain Relevance 44.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD40LG) extracellular region (CD40LG) plasma membrane (CD40LG)
Anatomy Link Frequency
platelet 23
B cells 12
leukocytes 9
blood 9
CSF 8
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1621 100.00 Very High Very High Very High
cytokine 1147 100.00 Very High Very High Very High
intrathecal 72 99.98 Very High Very High Very High
Arthritis 1986 99.92 Very High Very High Very High
cINOD 89 99.92 Very High Very High Very High
Pain 232 99.76 Very High Very High Very High
methotrexate 398 99.64 Very High Very High Very High
spinal inflammation 137 99.64 Very High Very High Very High
Adalimumab 245 99.62 Very High Very High Very High
tolerance 99 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1716 100.00 Very High Very High Very High
Dengue 1433 100.00 Very High Very High Very High
Epstein-barr Virus 466 100.00 Very High Very High Very High
Togavirus Infection 350 100.00 Very High Very High Very High
Cardiovascular Disease 248 100.00 Very High Very High Very High
Herpes Zoster 221 100.00 Very High Very High Very High
Stress 163 100.00 Very High Very High Very High
Hepatitis 136 100.00 Very High Very High Very High
Mycobacterial Infection 123 100.00 Very High Very High Very High
Cytomegalovirus Infection 94 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Waldenstrom's macroglobulinemia (WM) is a rare lymphoplasmacytic lymphoma characterized by a wide range of clinical presentations related to direct tumor infiltration and the production of IgM.
Gene_expression (production) of IgM associated with macroglobulinemia and cancer
1) Confidence 0.78 Published 2006 Journal Am. J. Hematol. Section Abstract Doc Link 16888782 Disease Relevance 1.10 Pain Relevance 0.19
ELISA test was used to detect specific IgM and IgG antibodies.
Gene_expression (detect) of IgM
2) Confidence 0.78 Published 2003 Journal Acta Med Croatica Section Body Doc Link 12879690 Disease Relevance 0.07 Pain Relevance 0
IgA- and IgM-producing cells were also found in normal CSF, but less frequently than cells secreting IgG and at proportions similar to those in peripheral blood.
Gene_expression (producing) of IgM in CSF
3) Confidence 0.75 Published 1989 Journal J. Neuroimmunol. Section Abstract Doc Link 2685038 Disease Relevance 0.25 Pain Relevance 0.23
Laboratory diagnosis is primarily based on serology such as indirect immunofluorescence or capture enzyme--linked immunosorbent assays which detect IgM antibodies and an increased level of IgG antibodies against Puumala virus.
Gene_expression (detect) of IgM associated with hantavirus infection
4) Confidence 0.75 Published 2001 Journal Nephrologie Section Abstract Doc Link 11715607 Disease Relevance 1.73 Pain Relevance 0.27
CD40 ligand (CD40L) is expressed not only on activated T cells but also on activated platelets.
Gene_expression (expressed) of CD40 ligand in platelets
5) Confidence 0.75 Published 2005 Journal Eur. J. Haematol. Section Abstract Doc Link 15613107 Disease Relevance 0.23 Pain Relevance 0.08
Patients with other non-dengue febrile illnesses (OFI) were defined by febrile illness with no detectable DEN-specific IgM, no detectable DEN RNA, and no obvious or reported bacterial etiology for their illness during the same study period.
Neg (no) Gene_expression (detectable) of IgM associated with dengue and fever
6) Confidence 0.75 Published 2011 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC3014977 Disease Relevance 1.74 Pain Relevance 0.07
A role of inflammatory stimulation on coagulation time and expression of CD40 ligand on platelets in acute coronary syndromes has not been described yet.
Gene_expression (expression) of CD40 ligand in platelets associated with acute coronary syndrome
7) Confidence 0.75 Published 2006 Journal Int. J. Cardiol. Section Abstract Doc Link 16182391 Disease Relevance 0.37 Pain Relevance 0.17
B19-specific IgM was detected in sera of 24/26 patients, and B19-specific IgG in 21 of 22 patients tested.
Gene_expression (detected) of IgM in B19
8) Confidence 0.75 Published 1986 Journal Blood Section Abstract Doc Link 3008891 Disease Relevance 0.97 Pain Relevance 0.08
Increased numbers of IgG- and IgM-producing cells were found in blood and bone marrow in the HMSN I patients.
Gene_expression (producing) of IgM in bone marrow associated with charcot marie tooth disease
9) Confidence 0.75 Published 1992 Journal J. Neurol. Sci. Section Abstract Doc Link 1281871 Disease Relevance 0.97 Pain Relevance 0.08
We determined the serum levels of soluble CD40 ligand (sCD40L) in patients with chronic coronary artery disease (CAD) and acute coronary syndrome (ACS).
Spec (determined) Gene_expression (levels) of CD40 ligand in coronary artery associated with acute coronary syndrome and coronary artery disease
10) Confidence 0.75 Published 2010 Journal Angiology Section Abstract Doc Link 20304868 Disease Relevance 1.44 Pain Relevance 0.67
We have therefore isolated cells from CSF to assess the frequency of Ig-secreting cells, utilizing a nitrocellulose immunospot assay for enumeration of the IgG-, IgA- and IgM-producing cells per 10(4) mononuclear cells (MNC) isolated from CSF and blood.
Gene_expression (producing) of IgM in MNC
11) Confidence 0.75 Published 1989 Journal J. Neuroimmunol. Section Abstract Doc Link 2685038 Disease Relevance 0.24 Pain Relevance 0.25
The ability of whole blood to produce IgM and IgG following stimulation is also strongly inhibited.
Gene_expression (produce) of IgM in blood
12) Confidence 0.72 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.35 Pain Relevance 0.42
We report herein that activated human B cells not only highly express Cox-2 and produce PGs, but that the NSAID indomethacin and Cox-2-selective drugs profoundly inhibit the ability of human B cells to produce IgG and IgM in vitro.
Gene_expression (produce) of IgM in B cells associated with cinod
13) Confidence 0.72 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15728468 Disease Relevance 0.38 Pain Relevance 0.34
Cerebrospinal fluid (CSF) showed mild lymphocytosis (9,400 leukocytes per microL; 89% lymphocytes) and elevated protein concentration (1322 mg/L) with blood brain barrier impairment and intrathecal IgM synthesis.
Gene_expression (synthesis) of IgM in lymphocytes
14) Confidence 0.72 Published 2005 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 16252210 Disease Relevance 0.08 Pain Relevance 0
Evaluation of MAT, IgM ELISA and PCR methods for the diagnosis of human leptospirosis.
Gene_expression (Evaluation) of IgM associated with leptospirosis
15) Confidence 0.67 Published 2006 Journal J. Microbiol. Methods Section Title Doc Link 16253361 Disease Relevance 0.88 Pain Relevance 0.08
CD154 is transiently expressed on activated T-cells and plays a crucial role in B-cell function [13].
Gene_expression (expressed) of CD154 in B-cell
16) Confidence 0.66 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.20 Pain Relevance 0.58
After stimulation in vitro, peripheral blood T-cells from patients with RA had increased and longer expression of CD154 compared to T-cells from controls [16].
Gene_expression (expression) of CD154 in blood associated with rheumatoid arthritis
17) Confidence 0.66 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.67 Pain Relevance 0.73
Activated T-cells expressing CD154 can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines [14].
Gene_expression (expressing) of CD154 in T-cells associated with inflammation and cytokine
18) Confidence 0.66 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.24 Pain Relevance 0.57
Data on IgM-RF were available in 415 (88.9%) out of these 467 patients, and 178 (42.9%) were positive for IgM-RF.


Gene_expression (positive) of IgM
19) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779400 Disease Relevance 0.51 Pain Relevance 0.22
Routine laboratory tests showed moderate pancytopenia, hypercalcemia (serum calcium, 15.9 mg/dL), IgM lambda-type monoclonal gammopathy (IgG, 405 mg/dL; IgA, 42 mg/dL; and IgM, 2023 mg/dL), and lambda-type Bence-Jones protein in the urine (0.8 g/d).
Gene_expression (showed) of IgM in urine associated with pancytopenia and hypercalcemia
20) Confidence 0.65 Published 2003 Journal Eur. J. Haematol. Section Abstract Doc Link 12581194 Disease Relevance 1.60 Pain Relevance 0.10

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