INT42172

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Context Info
Confidence 0.38
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.64
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
CdN 2
septal area 2
respiratory 2
neuronal 1
oocytes 1
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 5 99.96 Very High Very High Very High
Hippocampus 9 99.68 Very High Very High Very High
agonist 3 99.28 Very High Very High Very High
tetrodotoxin 4 99.12 Very High Very High Very High
Analgesic 2 95.36 Very High Very High Very High
Pain 6 93.76 High High
Nucleus accumbens 6 93.36 High High
fluoxetine 1 87.76 High High
Serotonin 2 86.64 High High
Bioavailability 6 84.68 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 68 99.38 Very High Very High Very High
Pain 5 93.76 High High
Stress 24 87.68 High High
Stroke 1 77.64 Quite High
Diabetes Mellitus 3 66.56 Quite High
Coronary Artery Disease 1 60.08 Quite High
INFLAMMATION 68 50.00 Quite Low
Overdose 2 46.72 Quite Low
Obesity 9 44.96 Quite Low
Asthma 60 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of oxotremorine and the cyclic GMP derivatives were not due to diminished ACh synthesis, since these compounds did not influence the reduction of tissue ACh resulting from treatment with K+ and atropine.
Negative_regulation (diminished) of Gene_expression (synthesis) of ACh
1) Confidence 0.38 Published 1980 Journal Brain Res. Section Abstract Doc Link 6243230 Disease Relevance 0 Pain Relevance 0.10
Local perfusion of 1 mumol/l of the sodium-channel blocker tetrodotoxin (TTX) through the probe resulted in 94% and 92% decrease in extracellular levels of ACh in the hippocampus and the septal area, respectively.
Negative_regulation (decrease) of Gene_expression (levels) of ACh in septal area associated with tetrodotoxin and hippocampus
2) Confidence 0.37 Published 1994 Journal Brain Res. Section Abstract Doc Link 7922524 Disease Relevance 0 Pain Relevance 0.50
The 5HT1A agonist 8-OH-DPAT given systemically again decreased extracellular levels of ACh, and the effect was dose-dependent.
Negative_regulation (decreased) of Gene_expression (levels) of ACh associated with agonist
3) Confidence 0.37 Published 1993 Journal Brain Res. Section Abstract Doc Link 8374797 Disease Relevance 0 Pain Relevance 0.54
Inhalational general anesthetics have recently been shown to inhibit neuronal nicotinic acetylcholine (ACh) receptors (nnAChRs) expressed in Xenopus laevis oocytes and in molluscan neurons.
Negative_regulation (inhibit) of in oocytes Gene_expression (expressed) of ACh in neuronal
4) Confidence 0.29 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11259617 Disease Relevance 0 Pain Relevance 0.10
The results showed that pain stimulation increased both AVP and Ach concentrations in the CdN perfusion liquid; AVP increased Ach concentration in the CdN perfusion liquid, while AVP receptor antagonist including d(CH(2))(5)Tyr(Me)AVP (V(1) receptor antagonist) and d(CH(2))(5)[D-Ile(2), Ile(4), Ala-NH(2)(9)]AVP (V(2) receptor antagonist) decreased Ach concentration in the CdN perfusion liquid.
Negative_regulation (decreased) of Gene_expression (concentration) of Ach in CdN associated with pain and antagonist
5) Confidence 0.28 Published 2010 Journal Peptides Section Abstract Doc Link 19948196 Disease Relevance 0.40 Pain Relevance 0.67
After stabilization of respiratory parameters (10–15 min), the rat was given Ach (dissolved in 0.9% NaCl) intravenously at an initial dose of 12.5 ?
Negative_regulation (stabilization) of Gene_expression (given) of Ach in respiratory
6) Confidence 0.07 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0.08 Pain Relevance 0
In contrast, vasodilation of arteries from HSD rats was impaired at only high doses of ACh which likewise demonstrated improved vasodilation in the presence of tiron and catalase but not EUK-134 (Figure 4).
Negative_regulation (impaired) of Gene_expression (doses) of ACh associated with increased venous pressure under development
7) Confidence 0.04 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 1.16 Pain Relevance 0.04

General Comments

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