INT42176

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Context Info
Confidence 0.39
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 3.71
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
heart 1
DFP (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 1 99.68 Very High Very High Very High
antinociception 4 98.62 Very High Very High Very High
fibrosis 24 98.32 Very High Very High Very High
narcan 2 97.90 Very High Very High Very High
Antinociceptive 4 97.20 Very High Very High Very High
Morphine 4 95.12 Very High Very High Very High
tolerance 8 92.48 High High
Endogenous opioid 2 75.00 Quite High
imagery 12 37.28 Quite Low
Pain 6 33.72 Quite Low
Disease Link Frequency Relevance Heat
Hypothermia 1 99.98 Very High Very High Very High
Recurrence 6 99.96 Very High Very High Very High
Myocardial Infarction 12 98.88 Very High Very High Very High
Agranulocytosis 48 98.84 Very High Very High Very High
Cirrhosis 30 98.56 Very High Very High Very High
Viral Infection 6 97.92 Very High Very High Very High
Thalassemia 126 97.84 Very High Very High Very High
Death 12 94.08 High High
Neutropenia 24 93.76 High High
Iron Overload 108 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone reduced DFP-induced antinociception but did not affect the attenuated locomotor activity or hypothermia produced by DFP.
Gene_expression (produced) of DFP associated with antinociception, hypothermia, eae and narcan
1) Confidence 0.39 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6243566 Disease Relevance 0.10 Pain Relevance 0.95
Thus the introduction of DFP was accompanied by much hope among hematologists and thalassemia patients alike.
Gene_expression (introduction) of DFP associated with thalassemia
2) Confidence 0.38 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.58 Pain Relevance 0
Alternate therapy is very common in clinical practice probably because by introducing oral DFP and reducing the weekly number of DFO infusions, it may be a practical approach to improve compliance with iron chelation for patients poorly compliant with DFO monotherapy.
Gene_expression (introducing) of DFP
3) Confidence 0.38 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.53 Pain Relevance 0
In 1998 one report suggested that DFP use was associated with an increase in liver fibrosis in 5 out 14 patients (Olivieri et al 1998).
Gene_expression (use) of DFP in liver associated with fibrosis and cirrhosis
4) Confidence 0.38 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.36 Pain Relevance 0.08
DFP and heart
Gene_expression (heart) of DFP in heart
5) Confidence 0.38 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.56 Pain Relevance 0
Because of risk of recurrence, reintroduction of DFP after an initial episode of agranulocytosis is not recommended.
Gene_expression (reintroduction) of DFP associated with agranulocytosis and recurrence
6) Confidence 0.38 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.99 Pain Relevance 0
While the use of DFO for about 2 decades prior to the introduction of DFP decreased morbidity and mortality among those who were able to comply with night-long infusions, a consistent proportion of patients refused therapy or at least were non-compliant, limiting the usefulness of this chelator, and a key factor in spurring on scientists to find an effective alternative chelator.
Gene_expression (introduction) of DFP
7) Confidence 0.38 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376085 Disease Relevance 0.60 Pain Relevance 0

General Comments

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