INT42184

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Context Info
Confidence 0.31
First Reported 1980
Last Reported 1980
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
dorsal 2
frontal cortex 2
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 2 97.84 Very High Very High Very High
Thalamus 2 96.72 Very High Very High Very High
Hippocampus 2 95.96 Very High Very High Very High
cerebral cortex 2 95.32 Very High Very High Very High
amygdala 2 88.16 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both alpha 1- and beta-receptor binding sites were reduced in number by 25-28% in the cerebellum of dorsal bundle-lesioned rats, whereas intraventricular administration of 6-hydroxydopamine to adult rats, which depletes norepinephrine in the cerebellum by 96%, increased cerebellar alpha 1- and beta-receptor binding by 33-40%.
Positive_regulation (increased) of beta-receptor Binding (binding) of in dorsal
1) Confidence 0.31 Published 1980 Journal Brain Res. Section Abstract Doc Link 6244065 Disease Relevance 0.09 Pain Relevance 0.26
Binding of [3H]WB-4101 to alpha 1-adrenergic receptors after dorsal bundle lesion was augmented generally to a lesser extent than beta-receptor binding, with significantly increased numbers of sites only in the frontal cortex (74%), thalamus (20%) and septum.
Positive_regulation (augmented) of beta-receptor Binding (binding) of in frontal cortex associated with urological neuroanatomy and thalamus
2) Confidence 0.26 Published 1980 Journal Brain Res. Section Abstract Doc Link 6244065 Disease Relevance 0.10 Pain Relevance 0.23

General Comments

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