INT42210

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Context Info
Confidence 0.49
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.48
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TSHB) extracellular region (TSHB) cellular nitrogen compound metabolic process (TSHB)
cell-cell signaling (TSHB)
Anatomy Link Frequency
thyroid 5
follicle 1
TSHB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 1 98.64 Very High Very High Very High
opiate 4 98.42 Very High Very High Very High
narcan 4 98.02 Very High Very High Very High
anesthesia 3 95.92 Very High Very High Very High
Morphine 1 76.36 Quite High
Endogenous opioid 1 75.36 Quite High
Dopamine 1 68.16 Quite High
Serotonin 1 67.12 Quite High
beta blocker 1 41.76 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypoxia 7 99.20 Very High Very High Very High
Thyroid Disease 30 98.92 Very High Very High Very High
Coronary Artery Disease 27 98.42 Very High Very High Very High
Hypothyroidism 2 96.98 Very High Very High Very High
Disease 15 94.92 High High
Stress 1 94.80 High High
Pituitary Cancer 9 89.96 High High
Coronary Heart Disease 1 88.48 High High
Renal Cancer 63 88.16 High High
Arrhythmias 2 Under Development 18 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preoperatively, the free thyroxine (fT4) and free triiodothyronine (fT3) levels were suppressed and thyroid stimulating hormone level was elevated with administration of iodine and propylthiouracil.
Positive_regulation (elevated) of thyroid stimulating hormone in thyroid
1) Confidence 0.49 Published 2008 Journal Masui Section Abstract Doc Link 18649649 Disease Relevance 0.37 Pain Relevance 0.26
Measuring Thyroid Stimulating Hormone (TSH) alone to screen for hyperthyroidism may be insufficient to appropriately evaluate the thyroid status in such cases.


Positive_regulation (Measuring) of Stimulating Hormone in Thyroid associated with thyroid disease
2) Confidence 0.20 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2270282 Disease Relevance 1.28 Pain Relevance 0
In primary hypothyroidism all patients, except the elderly and those with ischaemic heart disease, can safely be started on a full replacement dose of thyroxine; the aim is to restore thyroid stimulating hormone (TSH) to normal.
Positive_regulation (restore) of stimulating hormone in thyroid associated with hypothyroidism and coronary artery disease
3) Confidence 0.13 Published 2009 Journal Postgrad Med J Section Abstract Doc Link 20075403 Disease Relevance 1.21 Pain Relevance 0
A practical example is the use of colesevelam HCl with thyroid hormone, in that post marketing reports have suggested increases in thyroid stimulating hormone (TSH) levels in patients who have received colesevelam HCl co-administered with thyroid hormone replacement therapy (WelcholĀ® Product Information 2007).


Positive_regulation (increases) of thyroid stimulating hormone in thyroid
4) Confidence 0.09 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0 Pain Relevance 0
VEGF is primarily produced and secreted by fibroblasts.21 Its expression is regulated by a series factors including growth factors, p53 mutation, estrogen receptor activation, thyroid stimulating hormone, nitric oxide, and hypoxia.
Positive_regulation (activation) of stimulating hormone in thyroid associated with hypoxia
5) Confidence 0.01 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004565 Disease Relevance 0.52 Pain Relevance 0
Thus naloxone (NAL), a specific opiate antagonist, has been shown to reduce basal serum levels of PRL and GH, and to elevate serum levels of LH and follicle stimulating hormone in male rats.
Positive_regulation (elevate) of stimulating hormone in follicle associated with antagonist, narcan and opiate
6) Confidence 0.00 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6247213 Disease Relevance 0.09 Pain Relevance 0.75

General Comments

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