INT42229

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Context Info
Confidence 0.15
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Porcn) transferase activity, transferring acyl groups (Porcn)
Anatomy Link Frequency
brainstem 1
Porcn (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 99.00 Very High Very High Very High
medulla 1 96.78 Very High Very High Very High
sodium channel 1 88.72 High High
tetrodotoxin 3 86.88 High High
GABAergic 1 79.68 Quite High
antagonist 3 78.88 Quite High
Pain 1 53.72 Quite High
Disease Link Frequency Relevance Heat
Neuropathy 10 100.00 Very High Very High Very High
Plasmacytoma 2 98.60 Very High Very High Very High
Uremia 2 94.56 High High
Hypercalcemia 2 94.08 High High
Anaemia 2 93.48 High High
Cancer 4 75.00 Quite High
Osteoporosis 1 74.96 Quite High
Erythrocytosis 1 73.60 Quite High
Pain 1 53.72 Quite High
Multiple Myeloma 2 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In seven patients definite reversibility of PPN was observed after irradiation of plasmacytoma.
Negative_regulation (reversibility) of PPN associated with neuropathy and plasmacytoma
1) Confidence 0.15 Published 1980 Journal Medicine (Baltimore) Section Abstract Doc Link 6248719 Disease Relevance 1.27 Pain Relevance 0.05
We recorded intracellularly from PPN neurons in 12-21 day rat brainstem slices maintained in artificial cerebrospinal fluid (aCSF) and found that application of the nicotinic agonist 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) depolarized PPN neurons early in development, then hyperpolarized PPN neurons by day 21.
Negative_regulation (depolarized) of PPN in brainstem associated with medulla and agonist
2) Confidence 0.12 Published 2007 Journal Brain Res. Section Abstract Doc Link 17156760 Disease Relevance 0 Pain Relevance 0.47

General Comments

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