INT42229

Context Info Confidence 0.15 First Reported 1980 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.27 Pain Relevance 0.52

endoplasmic reticulum (Porcn) transferase activity, transferring acyl groups (Porcn)

Anatomy Link Frequency brainstem 1 Porcn (Mus musculus)

Pain Link Frequency Relevance Heat agonist 2 99.00 medulla 1 96.78 sodium channel 1 88.72 tetrodotoxin 3 86.88 GABAergic 1 79.68 antagonist 3 78.88 Pain 1 53.72

Disease Link Frequency Relevance Heat Neuropathy 10 100.00 Plasmacytoma 2 98.60 Uremia 2 94.56 Hypercalcemia 2 94.08 Anaemia 2 93.48 Cancer 4 75.00 Osteoporosis 1 74.96 Erythrocytosis 1 73.60 Pain 1 53.72 Multiple Myeloma 2 46.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In seven patients definite reversibility of PPN was observed after irradiation of plasmacytoma.

Negative_regulation (reversibility) of PPN associated with neuropathy and plasmacytoma

1) Confidence 0.15 Published 1980 Journal Medicine (Baltimore) Section Abstract Doc Link 6248719 Disease Relevance 1.27 Pain Relevance 0.05

We recorded intracellularly from PPN neurons in 12-21 day rat brainstem slices maintained in artificial cerebrospinal fluid (aCSF) and found that application of the nicotinic agonist 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) depolarized PPN neurons early in development, then hyperpolarized PPN neurons by day 21.

Negative_regulation (depolarized) of PPN in brainstem associated with medulla and agonist

2) Confidence 0.12 Published 2007 Journal Brain Res. Section Abstract Doc Link 17156760 Disease Relevance 0 Pain Relevance 0.47

General Comments

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