INT42243

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Context Info
Confidence 0.50
First Reported 1980
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 2.15
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Maoa) oxidoreductase activity (Maoa)
Anatomy Link Frequency
locus coeruleus 4
cerebral cortex 2
frontal cortex 2
Maoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 9 100.00 Very High Very High Very High
Dopamine 4 100.00 Very High Very High Very High
cerebral cortex 2 100.00 Very High Very High Very High
noradrenaline 14 99.96 Very High Very High Very High
dexamethasone 4 99.70 Very High Very High Very High
Catecholamine 3 98.88 Very High Very High Very High
Clonidine 5 98.04 Very High Very High Very High
Locus ceruleus 16 97.96 Very High Very High Very High
antagonist 2 95.36 Very High Very High Very High
antidepressant 1 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 53 99.84 Very High Very High Very High
Hypotension 5 99.76 Very High Very High Very High
Depression 2 99.00 Very High Very High Very High
Urological Neuroanatomy 2 98.80 Very High Very High Very High
INFLAMMATION 6 81.36 Quite High
Cerebrovascular Disease 1 78.96 Quite High
Myocardial Infarction 1 66.44 Quite High
Coronary Artery Disease 1 59.40 Quite High
Cancer 1 56.80 Quite High
Pulmonary Disease 1 51.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of monoamine oxidase by preincubation of cerebral cortex slices with 0.5 mM pargyline significantly increased the stimulation-evoked overflow of tritium, but clonidine was as effective as in the controls in inhibiting 3H-noradrenaline overflow.
Positive_regulation (increased) of Negative_regulation (Inhibition) of monoamine oxidase in cerebral cortex associated with noradrenaline, cerebral cortex, clonidine and monoamine
1) Confidence 0.50 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6249614 Disease Relevance 0 Pain Relevance 1.11
The aim of the present study was to investigate whether local inhibition of monoamine oxidase (MAO) influences basal and stimulus-induced release of 5-HT in the locus coeruleus.
Spec (whether) Positive_regulation (influences) of Spec (whether) Negative_regulation (inhibition) of monoamine oxidase in locus coeruleus associated with locus ceruleus and monoamine
2) Confidence 0.50 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10208305 Disease Relevance 0 Pain Relevance 0.39
The aim of the present study was to investigate whether local inhibition of monoamine oxidase (MAO) influences basal and stimulus-induced release of 5-HT in the locus coeruleus.
Spec (whether) Positive_regulation (influences) of Spec (whether) Negative_regulation (inhibition) of MAO in locus coeruleus associated with locus ceruleus and monoamine
3) Confidence 0.50 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10208305 Disease Relevance 0 Pain Relevance 0.39
Chronic inhibition of monoamine oxidase type A increases noradrenaline release in rat frontal cortex.
Positive_regulation (increases) of Negative_regulation (inhibition) of monoamine oxidase in frontal cortex associated with noradrenaline, urological neuroanatomy and monoamine
4) Confidence 0.50 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8391652 Disease Relevance 0.18 Pain Relevance 0.38
Inhibition of either peripheral L-aminoacid DOPA decarboxylase or monoamine oxydase enzymes increased this hypotensive effect. 3.
Positive_regulation (increased) of Negative_regulation (Inhibition) of monoamine oxydase associated with hypotension and monoamine
5) Confidence 0.32 Published 1982 Journal Gen. Pharmacol. Section Abstract Doc Link 6983471 Disease Relevance 0.26 Pain Relevance 0.20
Meloxicam and dexamethasone significantly restored the decreased monoamine oxidase activity and inhibited the cisplatin-induced increase in tryptophan hydroxylase activity toward the control levels.
Positive_regulation (restored) of Negative_regulation (decreased) of monoamine oxidase associated with dexamethasone and monoamine
6) Confidence 0.32 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18534574 Disease Relevance 0.40 Pain Relevance 0.64
One of the primary symptoms of smoking cessation has been depressive symptoms and it has been hypothesized that smokers may be increasing central dopamine levels by reducing monoamine oxidase inhibitor activity[116].
Positive_regulation (increasing) of Negative_regulation (reducing) of monoamine oxidase associated with dopamine, depression, nicotine addiction and monoamine
7) Confidence 0.04 Published 2006 Journal BMC Public Health Section Body Doc Link PMC1764891 Disease Relevance 1.31 Pain Relevance 0.48

General Comments

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