INT42250

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Context Info
Confidence 0.33
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.51
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
neuronal 1
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 9 97.84 Very High Very High Very High
Antinociceptive 10 97.08 Very High Very High Very High
antagonist 3 87.36 High High
Analgesic 4 86.24 High High
Action potential 27 84.60 Quite High
Morphine 1 77.44 Quite High
agonist 1 76.64 Quite High
Clonidine 1 76.00 Quite High
Inflammation 1 74.64 Quite High
withdrawal 1 70.80 Quite High
Disease Link Frequency Relevance Heat
Arrhythmogenic Right Ventricular Dysplasia 17 97.72 Very High Very High Very High
Neuroblastoma 3 95.08 Very High Very High Very High
INFLAMMATION 1 74.64 Quite High
Hyperalgesia 1 61.68 Quite High
Targeted Disruption 6 50.00 Quite Low
Heart Arrhythmia 9 43.92 Quite Low
Toxicity 3 27.36 Quite Low
Poisoning 1 25.00 Low Low
Heart Rate Under Development 1 25.00 Low Low
Cardiovascular Disorder Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the pyrethroids used in this study bind to the Na+ channel but are unable to stimulate 22Na+ entry.
Na Binding (bind) of
1) Confidence 0.33 Published 1980 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6250606 Disease Relevance 0.05 Pain Relevance 0.29
However, the increase of total sodium corresponded to 2.8 mM/min, suggesting that rapid binding and/or sequestration of Na+ are prominent features for pancreatic beta-cells.
Na Binding (binding) of
2) Confidence 0.31 Published 1995 Journal Biochim. Biophys. Acta Section Abstract Doc Link 7696351 Disease Relevance 0 Pain Relevance 0.15
The synergism observed between the effect of pyrethroids on 22Na+ influx on the one hand, and the effects of sea anemone toxin II, Androctonus scorpion toxin II, batrachotoxin, veratridine and dihydrograyanotoxin II on the other, indicates that the binding component for pyrethroids on the Na+ channel is distinct from the other toxin receptors.
Na Binding (binding) of
3) Confidence 0.29 Published 1980 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6250606 Disease Relevance 0.06 Pain Relevance 0.29
Interaction of pyrethroids with the Na+ channel in mammalian neuronal cells in culture.
Na Binding (Interaction) of in neuronal
4) Confidence 0.29 Published 1980 Journal Biochim. Biophys. Acta Section Title Doc Link 6250606 Disease Relevance 0.10 Pain Relevance 0.14
Since aconitine is known to bind to site II of Na+ channels, we determined the affinity of the aconitine-like derivatives in vitro to synaptosomal membranes by the [3H]-batrachotoxinin-binding assay and their properties on intrasynaptosomal concentrations of free Na+ and Ca2+ ([Na+]i and [Ca2+]i), both the latter determined fluorometrically with SBFI and Fura-2 respectively.
Na Binding (bind) of
5) Confidence 0.25 Published 1998 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9459571 Disease Relevance 0.31 Pain Relevance 0.50
Such systems lack functionally important proteins such as ankyrin proteins that form complexes with the Na+ channel in vivo (Abriel and Kass, 2005).
Na Binding (complexes) of
6) Confidence 0.04 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0 Pain Relevance 0
Gramicidin allows Na+ and K+ to pass, but not Cl?
Na Binding (pass) of
7) Confidence 0.02 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0.10

General Comments

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