INT42255

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Context Info
Confidence 0.56
First Reported 1980
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.83
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
neurons 1
brains 1
palate 1
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
gABA 175 99.12 Very High Very High Very High
Enkephalin 9 99.08 Very High Very High Very High
cerebral cortex 8 97.40 Very High Very High Very High
Serotonin 1 93.16 High High
Neurotransmitter 31 88.52 High High
Somatostatin 5 87.92 High High
Glutamate 74 84.64 Quite High
Clonidine 1 84.20 Quite High
antagonist 12 82.72 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 70 99.92 Very High Very High Very High
Targeted Disruption 27 99.68 Very High Very High Very High
Spasticity 80 99.48 Very High Very High Very High
Cerebral Palsy 172 99.20 Very High Very High Very High
Syndrome 59 96.20 Very High Very High Very High
Congenital Anomalies 14 96.20 Very High Very High Very High
Cleft Palate 16 96.16 Very High Very High Very High
Death 5 94.72 High High
Obesity 57 91.48 High High
Anorexia 14 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamic acid decarboxylase activity decreased by 37% 7 days after UBX, returned to normal by 14 days after surgery and then increased by 25% 90 days after UBX.
Negative_regulation (decreased) of Glutamic acid decarboxylase
1) Confidence 0.56 Published 1980 Journal Brain Res. Section Abstract Doc Link 6250675 Disease Relevance 0 Pain Relevance 0.32
Both transgenic and knock-in mice, however, showed a marked decrease in the level of expression of enkephalin mRNA in striatal neurons without significant decreases in mRNAs encoding substance P, GAD65, or GAD67.
Negative_regulation (decreases) of GAD67 in neurons associated with targeted disruption, enkephalin and substance p
2) Confidence 0.45 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10739639 Disease Relevance 0.79 Pain Relevance 0.57
However, the possibility that reduced GAD67 activity may cause CP in the patients studied herein, in a manner reminiscent of that seen in SPS, leads us to report our findings at this stage.
Negative_regulation (reduced) of GAD67 associated with syndrome and cerebral palsy
3) Confidence 0.42 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.74 Pain Relevance 0.11
The function of GAD25 is not known, but it may compete with GAD67 for incorporation into protein complexes.
Spec (may) Negative_regulation (compete) of GAD67
4) Confidence 0.42 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.70 Pain Relevance 0.11
This is not inconsistent with the mouse Gad1 knockout where complete loss of Gad1 enzymatic function (~20% reduction of total Gad activity in the cerebral cortex) resulted in a cleft palate phenotype and neonatal death [28,30].
Negative_regulation (loss) of Gad1 in palate associated with targeted disruption, cleft palate, generalized anxiety disorder, cerebral cortex and death
5) Confidence 0.42 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.54 Pain Relevance 0.14
We therefore performed detailed mutational screening of GAD1 in familial spastic CP probands and unaffected family members.


Negative_regulation (screening) of GAD1 associated with spasticity and cerebral palsy
6) Confidence 0.42 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.35 Pain Relevance 0.38
As well, GABA is thought to have significant effects on cell migration, differentiation, and synaptogenesis, yet fetal brains of mice lacking both GAD65 and GAD67 have 0.02% of normal GABA content and die at birth, but they have no obvious structural brain abnormalities [15].
Negative_regulation (lacking) of GAD67 in brains associated with gaba and congenital anomalies
7) Confidence 0.22 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.17 Pain Relevance 0.50
Also, approximately one-third of POMC/CART neurones express glutamic acid decarboxylase (GAD) mRNA [47].
Negative_regulation (neurones) of glutamic acid decarboxylase associated with generalized anxiety disorder
8) Confidence 0.04 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.54 Pain Relevance 0.41

General Comments

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