INT42256

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Context Info
Confidence 0.66
First Reported 1980
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.10
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
lateral 1
granule cells 1
Gad1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 6 98.88 Very High Very High Very High
GABAergic 9 98.82 Very High Very High Very High
withdrawal 9 98.60 Very High Very High Very High
bDMF 9 98.12 Very High Very High Very High
Serotonin 1 93.16 High High
Opioid 6 91.88 High High
narcan 4 91.08 High High
gABA 37 85.96 High High
Clonidine 1 84.20 Quite High
hyperexcitability 2 77.40 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 98.88 Very High Very High Very High
Opiate Addiction 5 92.32 High High
Convulsion 4 78.04 Quite High
Milium 2 73.52 Quite High
Spasticity 20 65.36 Quite High
Cerebral Palsy 43 64.72 Quite High
Heart Rate Under Development 5 59.12 Quite High
Syndrome 14 50.00 Quite Low
Neurodegenerative Disease 13 23.40 Low Low
Generalized Anxiety Disorder 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glutamic acid decarboxylase activity decreased by 37% 7 days after UBX, returned to normal by 14 days after surgery and then increased by 25% 90 days after UBX.
Positive_regulation (increased) of Glutamic acid decarboxylase
1) Confidence 0.66 Published 1980 Journal Brain Res. Section Abstract Doc Link 6250675 Disease Relevance 0 Pain Relevance 0.32
Sequencing of GAD1 exon sequences
Positive_regulation (Sequencing) of GAD1
2) Confidence 0.49 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.26 Pain Relevance 0
Neurons stained for both Fos and glutamic acid decarboxylase were greatly enhanced in all subdivisions of the periaqueductal gray following withdrawal, particularly in the lateral and ventrolateral divisions where the increase was up to 70-fold.
Positive_regulation (enhanced) of glutamic acid decarboxylase in lateral associated with withdrawal and central grey
3) Confidence 0.44 Published 2006 Journal Neuroscience Section Abstract Doc Link 16359817 Disease Relevance 0.76 Pain Relevance 1.25
Addition of 100 ng/ml recombinant brain derived neurotrophic factor (BDNF), which also induces the GABAergic phenotype in granule cells in vivo [30], led to a similar upregulation of GAD67 (Fig. 3f).
Positive_regulation (upregulation) of GAD67 in granule cells associated with gabaergic and bdmf
4) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.08 Pain Relevance 0.52

General Comments

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