INT4228

Context Info Confidence 0.75 First Reported 1976 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 50 Total Number 51 Disease Relevance 20.62 Pain Relevance 7.18

mitochondrion (CAT) small molecule metabolic process (CAT) aging (CAT) Golgi apparatus (CAT) endoplasmic reticulum (CAT) peroxisome (CAT)

Anatomy Link Frequency erythrocytes 4 brain 2 optic 2 blood 2 epidermis 2 CAT (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 6 100.00 Dopamine 28 99.84 Dismenorea 11 99.80 cva 5 99.64 endometriosis 60 99.48 Bile 7 99.42 Morphine 6 99.22 fluoxetine 11 98.48 Neurotransmitter 10 98.40 agonist 4 98.24

Disease Link Frequency Relevance Heat Stress 510 100.00 Urological Neuroanatomy 65 100.00 Disorder Of Lipid Metabolism 10 100.00 Coronary Heart Disease 7 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 15 99.90 Targeted Disruption 9 99.86 Dysmenorrhea 6 99.80 Neurodegenerative Disease 17 99.72 Cv General 4 Under Development 4 99.64 Diabetes Mellitus 192 99.48

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

OBJECTIVE: To determine if adenoviral-mediated transfer of the gene for catalase (CAT), the reactive oxygen species scavenger, suppresses experimental optic neuritis.

Gene_expression (transfer) of catalase in optic associated with optic neuritis and neuritis

1) Confidence 0.75 Published 1999 Journal Arch. Ophthalmol. Section Abstract Doc Link 10565523 Disease Relevance 0.17 Pain Relevance 0.17

The presence of H. pylori is confirmed by the presence of a gram negative curved bacilli and a positive test for urease, oxidase and catalase production.

Gene_expression (production) of catalase

2) Confidence 0.75 Published 2004 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC543444 Disease Relevance 0.23 Pain Relevance 0

Suspected H. pylori colonies were tested for urease, oxidase and catalase production.

Gene_expression (production) of catalase

3) Confidence 0.75 Published 2004 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC543444 Disease Relevance 0.15 Pain Relevance 0

Each isolate was tested for the production of catalase in the presence of 3% hydrogen peroxide.

Gene_expression (production) of catalase

4) Confidence 0.75 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1277855 Disease Relevance 0.08 Pain Relevance 0

OBJECTIVE: To determine if adenoviral-mediated transfer of the gene for catalase (CAT), the reactive oxygen species scavenger, suppresses experimental optic neuritis.

Gene_expression (transfer) of CAT in optic associated with optic neuritis and neuritis

5) Confidence 0.75 Published 1999 Journal Arch. Ophthalmol. Section Abstract Doc Link 10565523 Disease Relevance 0.17 Pain Relevance 0.17

The purity of the cultures was confirmed by Gram staining, catalase production, colony morphology on blood agar and using a biochemical identification kit (API 20 Strep, bioMerieux: Marcy-I’Etoile, France).

Gene_expression (production) of catalase in blood

6) Confidence 0.75 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609913 Disease Relevance 0 Pain Relevance 0

Low levels of CAT were expressed constitutively.

Gene_expression (expressed) of CAT

7) Confidence 0.75 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8915585 Disease Relevance 0 Pain Relevance 0.11

Transgenic flies expressing increased Cu/ZnSOD and catalase [22] displayed extended lifespan.

Gene_expression (expressing) of catalase associated with targeted disruption and lifespan

8) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637430 Disease Relevance 1.17 Pain Relevance 0

Venous blood samples were obtained from all patients to measure the levels of AOPP, MPO, CAT, and other biochemical parameters.

Gene_expression (levels) of CAT in blood associated with urological neuroanatomy

9) Confidence 0.75 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768243 Disease Relevance 0.99 Pain Relevance 0.05

In vitro, we found that expression of a transiently transfected human ppEnk promoter-driven chloramphenicol acetyltransferase (CAT) reporter construct was induced by DAergic agonists, as much as 20-fold.

Gene_expression (expression) of CAT associated with agonist

10) Confidence 0.75 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867759 Disease Relevance 0 Pain Relevance 0.50

In vivo, regulation of CAT expression by DA was tested by implanting the genetically modified astrocytes into the normal striatum and the contralateral striatum which had > 95% DA depletion induced by a previous 6-hydroxy-DA lesion of the substantia nigra.

Gene_expression (expression) of CAT in astrocytes associated with dopamine and substantia nigra

11) Confidence 0.75 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 7867759 Disease Relevance 0 Pain Relevance 0.66

In the viable layers of the epidermis, lipid-soluble antioxidants, mainly alphatocopherol, and antioxidant enzymes like catalase (CAT), superoxide dismutases (SOD), glutathione peroxidases (GPx), and peroxiredoxins are abundantly expressed [9].

Gene_expression (expressed) of CAT in epidermis

12) Confidence 0.75 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.17 Pain Relevance 0

Apart from revealing the advantages and defects of the two techniques, the results confirm the preference for CAT expressed elsewhere in the literature.

Gene_expression (expressed) of CAT

13) Confidence 0.75 Published 1987 Journal Minerva Med. Section Abstract Doc Link 3696452 Disease Relevance 0.16 Pain Relevance 0

Morphine does not appreciably activate HIV/LTR-CAT expression in human MOLT-3 and other T cells.

Gene_expression (expression) of CAT in T cells associated with acquired immune deficiency syndrome or hiv infection and morphine

14) Confidence 0.75 Published 1990 Journal AIDS Res. Hum. Retroviruses Section Abstract Doc Link 2252636 Disease Relevance 1.54 Pain Relevance 0.53

Study of Ota et al. [12] showed that women with endometriosis and adenomyosis had elevated expression of CAT in comparison to healthy women but the expression did not show the usual, fluctuating pattern characteristic for the menstrual cycle.

Gene_expression (expression) of CAT associated with endometriosis and dismenorea

15) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.53 Pain Relevance 0.19

Assay of CAT activity

Gene_expression (activity) of CAT

16) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 0 Pain Relevance 0

Macroangiopathy was associated with significantly higher frequency of C allele in SOD1 gene (0,58 in MA group vs. 0,42 in DM group without complications, p < 0,01), lower frequency of C alelle (Ala) in SOD2 gene (0,28 in MA group vs. 0,39 in DM group without vascular complications, p < 0,05) whereas no such distribution was found in CAT gene, p = 0,594.

Neg (no) Gene_expression (found) of CAT associated with diabetes mellitus

17) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.26 Pain Relevance 0

We found no statistically significant differences between frequencies in alleles of CAT SNP between diabetic patients and healthy subjects (p = 0,294) (Tab. 3).

Gene_expression (alleles) of CAT associated with diabetes mellitus

18) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2386118 Disease Relevance 0.80 Pain Relevance 0

The CAT -262 C ?

Gene_expression (The) of CAT

19) Confidence 0.65 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2474584 Disease Relevance 0 Pain Relevance 0.05

In patients with endometriosis and adenomyosis, SOD and CAT were found to be abnormally expressed [11,12], while patients with endometriosis have lowered GPx activity [13].

Gene_expression (expressed) of CAT associated with endometriosis and dismenorea

20) Confidence 0.65 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2805669 Disease Relevance 1.36 Pain Relevance 0.20

General Comments

This test has worked.