INT42307

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Context Info
Confidence 0.41
First Reported 1980
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.09
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
uterine 2
central nervous system 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 349 100.00 Very High Very High Very High
agonist 116 100.00 Very High Very High Very High
GABA receptor 5 100.00 Very High Very High Very High
Central nervous system 3 99.68 Very High Very High Very High
GABAergic 22 84.76 Quite High
Dorsal horn 1 64.80 Quite High
Spinal cord 3 63.88 Quite High
qutenza 1 63.36 Quite High
primary afferent fibers 1 62.00 Quite High
Dismenorea 1 36.40 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 94.76 High High
Dysmenorrhea 1 36.40 Quite Low
Decapitation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Experimental changes of GABA receptor binding in the central nervous system (author's transl)].
Regulation (changes) of GABA Binding (binding) of in central nervous system associated with gaba receptor and central nervous system
1) Confidence 0.41 Published 1980 Journal Wien. Klin. Wochenschr. Section Title Doc Link 6258330 Disease Relevance 0.09 Pain Relevance 0.57
This reflects a general rule that a very brief agonist transient renders the IPSCs particularly sensitive to modulators affecting GABA binding and the larger the distance from saturation, the larger the impact of such modifiers (Mozrzymas et al. 1999, 2003b; Mozrzymas, 2004).
Regulation (affecting) of GABA Binding (binding) of associated with gaba and agonist
2) Confidence 0.27 Published 2007 Journal The Journal of Physiology Section Body Doc Link PMC2375456 Disease Relevance 0 Pain Relevance 0.40
The effects of flurazepam and zolpidem on mIPSCs and on current responses to exogenous GABA applications suggest that these BDZ receptor agonists modulate both binding and gating of GABAAR.
Regulation (modulate) of GABA Binding (binding) of associated with gaba and agonist
3) Confidence 0.20 Published 2007 Journal The Journal of Physiology Section Body Doc Link PMC2375456 Disease Relevance 0 Pain Relevance 0.45
We determined how allopregnanolone affected the binding of muscimol, a ligand for the GABA(A) receptor, to rat uterine GABA(A) receptors throughout pregnancy.
Regulation (affected) of GABA Spec (determined) Binding (binding) of in uterine associated with gaba
4) Confidence 0.17 Published 2001 Journal Endocrinology Section Abstract Doc Link 11316740 Disease Relevance 0 Pain Relevance 0.60

General Comments

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