INT42311

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Context Info
Confidence 0.43
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
shell 1
neuronal 1
foramen 1
nerve 1
external 1
HMI (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 3 99.28 Very High Very High Very High
Nucleus accumbens 64 98.98 Very High Very High Very High
tetrodotoxin 7 96.64 Very High Very High Very High
cocaine 5 96.16 Very High Very High Very High
guanethidine 2 94.04 High High
alcohol 2 92.72 High High
Dopamine 44 90.32 High High
antagonist 10 72.32 Quite High
Action potential 40 72.08 Quite High
Sciatica 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 4 50.00 Quite Low
Nerve Root Compression 3 50.00 Quite Low
Aging 1 22.04 Low Low
Stress 5 20.24 Low Low
Pain 1 19.12 Low Low
Arrhythmia Under Development 9 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Bites And Stings 6 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Heart Rate Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ITO was unaffected by tetraethylammonium (TEA), but was blocked by 4-aminopyridine.
Neg (unaffected) Regulation (unaffected) of ITO
1) Confidence 0.43 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10026789 Disease Relevance 0 Pain Relevance 0.09
If CS signaling is unaffected (and CS responses are even improved), and if US processing was unaffected in the bees selected for the experiments, how could IPA act on the association between CS and US in order to impair learning?
Regulation (unaffected) of IPA
2) Confidence 0.26 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0 Pain Relevance 0.08
The kinetics, gating, and selectivity of Ito1 recorded after inactivation of INa were unaffected by drastic reductions in external Na+.
Neg (unaffected) Regulation (unaffected) of Ito1 in external
3) Confidence 0.14 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038916 Disease Relevance 0 Pain Relevance 0.22
The contractile responses of IPA and IPV to TNS and NE were enhanced after inhibition of neuronal reuptake of NE (uptake1) with cocaine, as well as after blockade of extraneuronal reuptake of NE (uptake2) with hydrocortisone.
Regulation (responses) of IPA in neuronal associated with cocaine
4) Confidence 0.08 Published 1981 Journal Am. J. Physiol. Section Abstract Doc Link 6258452 Disease Relevance 0 Pain Relevance 0.32
The contractile responses of IPA and IPV to TNS and NE were reduced in a concentration-dependent way, by the alpha-adrenergic receptor-blocking agents phentolamine, tolazoline and clonidine.
Regulation (responses) of IPA in IPV associated with clonidine
5) Confidence 0.08 Published 1981 Journal Am. J. Physiol. Section Abstract Doc Link 6258452 Disease Relevance 0 Pain Relevance 0.30
The responses of IPA and DMV to norepinephrine (NE), transmural nerve stimulation, phenylephrine (PE), guanabenz, and clonidine were obtained in the presence and absence of alterations in pH, extracellular calcium ion, sulfhydryl bond reduction and oxidation, and destruction of adrenergic nerves with 6-hydroxydopamine.
Regulation (responses) of IPA in nerve associated with clonidine
6) Confidence 0.04 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6313173 Disease Relevance 0 Pain Relevance 0.10
Transmural heterogeneities in IKs and transient outward current (Ito) were simulated as in previous studies (McIntosh et al. 2000; Gima & Rudy 2002).
Regulation (simulated) of Ito
7) Confidence 0.03 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.07
Current research advocates that the NAc shell is particularly important for mediating the influence of contextual stimuli on conditioned behavior (Ito et al. 2008).
Regulation (influence) of Ito in shell associated with nucleus accumbens
8) Confidence 0.03 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2770635 Disease Relevance 0 Pain Relevance 0.46
In three patients, the HMI was abnormal on S1-foramen stimulation.
Regulation (abnormal) of HMI in foramen
9) Confidence 0.02 Published 2010 Journal Clin Neurophysiol Section Body Doc Link 20417153 Disease Relevance 0 Pain Relevance 0

General Comments

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