INT42311

Context Info Confidence 0.43 First Reported 1981 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 0 Pain Relevance 1.64

Anatomy Link Frequency shell 1 neuronal 1 foramen 1 nerve 1 external 1 HMI (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 3 99.28 Nucleus accumbens 64 98.98 tetrodotoxin 7 96.64 cocaine 5 96.16 guanethidine 2 94.04 alcohol 2 92.72 Dopamine 44 90.32 antagonist 10 72.32 Action potential 40 72.08 Sciatica 4 50.00

Disease Link Frequency Relevance Heat Cardiovascular Disorder Under Development 4 50.00 Nerve Root Compression 3 50.00 Aging 1 22.04 Stress 5 20.24 Pain 1 19.12 Arrhythmia Under Development 9 5.00 Syndrome 8 5.00 Bites And Stings 6 5.00 Toxicity 4 5.00 Heart Rate Under Development 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The ITO was unaffected by tetraethylammonium (TEA), but was blocked by 4-aminopyridine.

Neg (unaffected) Regulation (unaffected) of ITO

1) Confidence 0.43 Published 1998 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 10026789 Disease Relevance 0 Pain Relevance 0.09

If CS signaling is unaffected (and CS responses are even improved), and if US processing was unaffected in the bees selected for the experiments, how could IPA act on the association between CS and US in order to impair learning?

Regulation (unaffected) of IPA

2) Confidence 0.26 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2936933 Disease Relevance 0 Pain Relevance 0.08

The kinetics, gating, and selectivity of Ito1 recorded after inactivation of INa were unaffected by drastic reductions in external Na+.

Neg (unaffected) Regulation (unaffected) of Ito1 in external

3) Confidence 0.14 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038916 Disease Relevance 0 Pain Relevance 0.22

The contractile responses of IPA and IPV to TNS and NE were enhanced after inhibition of neuronal reuptake of NE (uptake1) with cocaine, as well as after blockade of extraneuronal reuptake of NE (uptake2) with hydrocortisone.

Regulation (responses) of IPA in neuronal associated with cocaine

4) Confidence 0.08 Published 1981 Journal Am. J. Physiol. Section Abstract Doc Link 6258452 Disease Relevance 0 Pain Relevance 0.32

The contractile responses of IPA and IPV to TNS and NE were reduced in a concentration-dependent way, by the alpha-adrenergic receptor-blocking agents phentolamine, tolazoline and clonidine.

Regulation (responses) of IPA in IPV associated with clonidine

5) Confidence 0.08 Published 1981 Journal Am. J. Physiol. Section Abstract Doc Link 6258452 Disease Relevance 0 Pain Relevance 0.30

The responses of IPA and DMV to norepinephrine (NE), transmural nerve stimulation, phenylephrine (PE), guanabenz, and clonidine were obtained in the presence and absence of alterations in pH, extracellular calcium ion, sulfhydryl bond reduction and oxidation, and destruction of adrenergic nerves with 6-hydroxydopamine.

Regulation (responses) of IPA in nerve associated with clonidine

6) Confidence 0.04 Published 1983 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 6313173 Disease Relevance 0 Pain Relevance 0.10

Transmural heterogeneities in IKs and transient outward current (Ito) were simulated as in previous studies (McIntosh et al. 2000; Gima & Rudy 2002).

Regulation (simulated) of Ito

7) Confidence 0.03 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0 Pain Relevance 0.07

Current research advocates that the NAc shell is particularly important for mediating the influence of contextual stimuli on conditioned behavior (Ito et al. 2008).

Regulation (influence) of Ito in shell associated with nucleus accumbens

8) Confidence 0.03 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2770635 Disease Relevance 0 Pain Relevance 0.46

In three patients, the HMI was abnormal on S1-foramen stimulation.

Regulation (abnormal) of HMI in foramen

9) Confidence 0.02 Published 2010 Journal Clin Neurophysiol Section Body Doc Link 20417153 Disease Relevance 0 Pain Relevance 0

General Comments

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