INT42312

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Context Info
Confidence 0.54
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 6.13
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Chat) transferase activity, transferring acyl groups (Chat)
Anatomy Link Frequency
amacrine cells 2
afferent neurons 2
forebrain 1
motor neurons 1
dorsal horn 1
Chat (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 221 100.00 Very High Very High Very High
Dorsal horn 63 99.68 Very High Very High Very High
analgesia 63 99.62 Very High Very High Very High
tetrodotoxin 9 99.60 Very High Very High Very High
Pain 100 98.36 Very High Very High Very High
antagonist 32 98.32 Very High Very High Very High
spinal dorsal horn 56 97.76 Very High Very High Very High
agonist 54 97.72 Very High Very High Very High
Spinal cord 99 97.28 Very High Very High Very High
Neurotransmitter 8 89.16 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 323 100.00 Very High Very High Very High
Pain 59 98.36 Very High Very High Very High
Low Back Pain 49 97.88 Very High Very High Very High
Nociception 134 94.00 High High
Disease 122 91.28 High High
Targeted Disruption 51 91.04 High High
Cognitive Disorder 9 88.56 High High
Injury 7 83.40 Quite High
Neuroblastoma 5 82.16 Quite High
Vibrio Infection 2 75.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activity of the nerve-specific enzyme choline acetyltransferase, is significantly decreased by early TTX treatment, while DNA and protein content of the cultures (primarily contributed by glial and fibroblastic cells) is not affected.
Negative_regulation (decreased) of choline acetyltransferase in nerve associated with tetrodotoxin
1) Confidence 0.54 Published 1981 Journal Brain Res. Section Abstract Doc Link 6258736 Disease Relevance 0.31 Pain Relevance 0.73
However, there was no reduction in ChAT level in the ventral motor neurons due to the AS-ODN (data not shown).


Neg (no) Negative_regulation (reduction) of ChAT in motor neurons
2) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.38 Pain Relevance 0.26
A prominent difference between ChAT+ and ChAT?
Negative_regulation (difference) of ChAT
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
The present data demonstrate that AS-ODN pretreatment caused selective down-regulation of DRG-originating ChAT protein in the dorsal horn.
Negative_regulation (regulation) of ChAT protein in dorsal horn associated with dorsal root ganglion and dorsal horn
4) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.56 Pain Relevance 0.75
In the present study we attempted to clarify the role of primary afferent neurons in this tonic inhibition and to reproduce nicotinic analgesia with low doses by down-regulation of ChAT activity, based on this speculation.


Negative_regulation (down) of ChAT in afferent neurons associated with analgesia
5) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.63 Pain Relevance 0.76
In the present study we attempted to clarify the role of primary afferent neurons in this tonic inhibition and to reproduce nicotinic analgesia with low doses by down-regulation of ChAT activity, based on this speculation.


Negative_regulation (regulation) of ChAT in afferent neurons associated with analgesia
6) Confidence 0.38 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.63 Pain Relevance 0.76
ANA increased the propensity of mice to stay and perform behaviors in the anxiogenic open arms of the maze, lowered pain sensitivity and reduced behavioral flexibility in a Morris water maze task, also reducing ChAT immunoreactivity in the basal forebrain.
Negative_regulation (reducing) of ChAT in forebrain associated with pain
7) Confidence 0.37 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 20188766 Disease Relevance 0.25 Pain Relevance 0.17
Pretreatments with a ChAT AS-ODN, which reduced the ChAT protein level in DRG neurons and in the terminal region of the spinal dorsal horn, led to significant decreases in the thresholds for mechanical and thermal nociception.
Negative_regulation (reduced) of ChAT protein in spinal associated with nociception, dorsal root ganglion and spinal dorsal horn
8) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.84 Pain Relevance 0.78
As shown in Figs. 2A and 2B, ChAT-positive immunoreactivities in most cells were reduced by AS-ODN treatments, but not by MS-ODN treatments.
Negative_regulation (reduced) of ChAT
9) Confidence 0.37 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.29 Pain Relevance 0.40
A prominent difference between ChAT+ and ChAT?
Negative_regulation (difference) of ChAT
10) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2883570 Disease Relevance 0 Pain Relevance 0
Our present study shows that small- and large-diameter DRG neurons in mice are ChAT positive.
Negative_regulation (positive) of ChAT in neurons associated with dorsal root ganglion
11) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.62 Pain Relevance 0.51
Analysis of tyrosine kinase-deficient ret mutant mice by ISH shows a massive loss of ChAT and VAChT mRNAs in sympathetic ganglia (Burau et al. 2004).
Negative_regulation (loss) of ChAT in sympathetic
12) Confidence 0.30 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.22 Pain Relevance 0.03
levels, without inhibiting ChAT [47].
Negative_regulation (inhibiting) of ChAT
13) Confidence 0.16 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1559913 Disease Relevance 1.04 Pain Relevance 0.14
In addition to a decrease in the percentage of type-II cholinergic amacrine cells, we found that the density of ChAT-positive cells was decreased by treatment with both a muscarinic AChR antagonist and agonist (ANOVA p = 0.0013, GCL; p = 0.0004, INL; Fig 6h).
Negative_regulation (decreased) of ChAT in amacrine cells associated with antagonist and agonist
14) Confidence 0.12 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2267169 Disease Relevance 0.05 Pain Relevance 0.13
A normal distribution of glial fibrillary acid protein (GFAP; labels Muller cells), calbindin- (CALB; labels horizontal cells) and choline acetyltransferase (ChAT; labels cholinergic amacrine cells) immunoreactivity was observed in both control and UF008/SAP injected eyes.
Negative_regulation (distribution) of choline acetyltransferase in amacrine cells
15) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2519834 Disease Relevance 0.30 Pain Relevance 0

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