INT42317

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Context Info
Confidence 0.43
First Reported 1981
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 33
Disease Relevance 3.13
Pain Relevance 4.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dlat) transferase activity, transferring acyl groups (Dlat)
Anatomy Link Frequency
bar 1
neurons 1
spinal cord neurons 1
gland 1
hippocampus 1
Dlat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 82 100.00 Very High Very High Very High
anesthesia 47 99.84 Very High Very High Very High
Spinal cord 132 99.48 Very High Very High Very High
Hippocampus 146 98.48 Very High Very High Very High
Somatostatin 157 98.40 Very High Very High Very High
backache 1 98.40 Very High Very High Very High
antagonist 46 98.10 Very High Very High Very High
spinal dorsal horn 204 98.08 Very High Very High Very High
Acupuncture 45 98.02 Very High Very High Very High
Dopamine 76 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 69 100.00 Very High Very High Very High
Targeted Disruption 10 99.58 Very High Very High Very High
Disease 51 98.44 Very High Very High Very High
Low Back Pain 1 98.40 Very High Very High Very High
Lactic Acidosis 1 97.44 Very High Very High Very High
Epilepsy 24 96.84 Very High Very High Very High
Brain Hemorrhage 2 95.56 Very High Very High Very High
Nociception 48 93.20 High High
Cv General 4 Under Development 59 76.76 Quite High
Inflammatory Pain 24 75.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The E1b and E2 peaks seen in the awake state, on the other hand, were completely abolished by anesthesia.
Negative_regulation (abolished) of E2 associated with anesthesia
1) Confidence 0.43 Published 1981 Journal Brain Res. Bull. Section Abstract Doc Link 6258757 Disease Relevance 0 Pain Relevance 0.23
Subunit selectivity of E2 inhibition on GlyRs
Negative_regulation (inhibition) of E2
2) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0
In the following experiments, therefore, we used HIP neurons to study the mechanisms underlying E2 inhibition.
Negative_regulation (inhibition) of E2 in neurons
3) Confidence 0.33 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.06
Effect of E2 on androgen receptor (AR) of prostate with TP (18.5 mg/kg)
Negative_regulation (Effect) of E2
4) Confidence 0.30 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (3.7 mg/kg)
Negative_regulation (Effect) of E2
5) Confidence 0.30 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (0.74 mg/kg)
Negative_regulation (Effect) of E2
6) Confidence 0.30 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
Effect of E2 on androgen receptor (AR) of prostate with TP (0.15 mg/kg)
Negative_regulation (Effect) of E2
7) Confidence 0.30 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
We further employed tamoxifen, a classical ER antagonist in the hippocampus [15], to examine whether membrane-localized classical ERs were involved in E2 inhibition of IGly.
Negative_regulation (inhibition) of E2 in hippocampus associated with antagonist and hippocampus
8) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.10
M), the inactive stereoisomer of E2, mimicked the inhibitory effect of E2 on IGly (Figure 2A6 and 2B1, P > 0.05, Unpaired Student's t-test), suggesting that E2 inhibition on GlyR is independent of classical ERs.


Negative_regulation (inhibition) of E2
9) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.07
According to the selectivity of E2 inhibition on ?
Negative_regulation (inhibition) of E2
10) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0.69 Pain Relevance 0.59
Nevertheless, E2 is not charged at physiological pH and inhibited IGly independent of membrane potentials (P.J. and T.L.X., unpublished data), which makes it unlikely that E2 acts as an open-channel blocker.
Negative_regulation (inhibited) of E2
11) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.03
Two general mechanisms may underlie the noncompetitive inhibition of E2 on GlyR, open-channel blocker or allosteric modulation.
Negative_regulation (inhibition) of E2
12) Confidence 0.27 Published 2009 Journal Mol Pain Section Body Doc Link PMC2651124 Disease Relevance 0 Pain Relevance 0.03
There were seven groups which were all administered with TP of 18.5 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
13) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 3.7 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
14) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 0.74 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
15) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 0.15 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
16) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 92.6 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
17) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 18.5 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
18) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 3.7 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
19) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0 Pain Relevance 0
There were seven groups which were all administered with TP of 92.6 mg/kg, with different dosages of E2 (0, 0.4, 2.0, 10, 50, 250, and 1250 µg/kg), respectively.
Negative_regulation (dosages) of E2
20) Confidence 0.26 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2959216 Disease Relevance 0.07 Pain Relevance 0

General Comments

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