INT42318

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Context Info
Confidence 0.31
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.57
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hpd) Golgi apparatus (Hpd) endoplasmic reticulum (Hpd)
cytoplasm (Hpd)
Hpd (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 8 99.80 Very High Very High Very High
antagonist 1 90.40 High High
opiate 2 89.96 High High
narcan 2 89.52 High High
withdrawal 1 86.96 High High
Opioid 1 86.52 High High
Neuropathic pain 1 86.08 High High
Central nervous system 1 85.12 High High
tail-flick 1 82.16 Quite High
Eae 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Sleep Disorders 2 99.52 Very High Very High Very High
Opiate Addiction 1 86.96 High High
Neuropathic Pain 1 86.08 High High
INFLAMMATION 2 81.60 Quite High
Asthma 1 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies indicate that TRH and HPD can antagonize THC-induced sedation and analgesia and that HPD may be an active metabolite of TRH.
Negative_regulation (metabolite) of HPD associated with sleep disorders and analgesia
1) Confidence 0.31 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6258926 Disease Relevance 0.16 Pain Relevance 1.03
Enzymatic analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate (HPP) tautomerase activity of MIF and an allosteric binding site of AV411 and AV1013 is detected by NMR.
Negative_regulation (inhibitors) of p-hydroxyphenylpyruvate
2) Confidence 0.00 Published 2010 Journal Proc. Natl. Acad. Sci. U.S.A. Section Abstract Doc Link 20534506 Disease Relevance 0.40 Pain Relevance 0.22

General Comments

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