INT42319

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Context Info
Confidence 0.44
First Reported 1980
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 11.25
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hpd) Golgi apparatus (Hpd) endoplasmic reticulum (Hpd)
cytoplasm (Hpd)
Anatomy Link Frequency
T cell 3
eukaryotic cells 1
liver 1
FRT 1
kidney 1
Hpd (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 8 100.00 Very High Very High Very High
Inflammation 23 97.08 Very High Very High Very High
Potency 8 88.00 High High
Eae 1 75.00 Quite High
imagery 12 69.20 Quite High
tail-flick 1 67.68 Quite High
cytokine 22 67.56 Quite High
anesthesia 9 57.84 Quite High
narcan 2 52.80 Quite High
opiate 2 51.76 Quite High
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 816 100.00 Very High Very High Very High
Sleep Disorders 2 100.00 Very High Very High Very High
Hepatocellular Cancer 24 99.56 Very High Very High Very High
Viral Infection 48 99.20 Very High Very High Very High
Targeted Disruption 136 97.64 Very High Very High Very High
Immunization 16 97.32 Very High Very High Very High
Infection 144 97.12 Very High Very High Very High
INFLAMMATION 24 97.08 Very High Very High Very High
Cytomegalovirus Infection 24 96.60 Very High Very High Very High
Obesity 20 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The influence of thyrotropin releasing hormone (TRH) and its postulated metabolite histidyl-proline diketopiperazine (HPD) on sedation and analgesia produced by delta 9-tetrahydrocannabinol (THC) was investigated in mice.
Gene_expression (produced) of HPD associated with sleep disorders and analgesia
1) Confidence 0.44 Published 1980 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6258926 Disease Relevance 0.10 Pain Relevance 0.54
Traditionally, 4-hydroxyphenylpyruvic acid dioxygenase (HPD) has been considered as an enzyme primarily expressed in liver and to a lesser extent in kidney [50].
Gene_expression (expressed) of HPD in kidney
2) Confidence 0.25 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.43 Pain Relevance 0.08
This previous study is agreement with the current study in which HPD is exclusively detected in the liver.
Gene_expression (detected) of HPD in liver
3) Confidence 0.22 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1888706 Disease Relevance 0.41 Pain Relevance 0.08
The pOG44 vector encodes FLP recombinase which directs insertion of the modified pcDNA5/FRT targeting vector into the cell's FRT site; hygromycin B resistance is conferred upon insertion of the vector into the site.
Gene_expression (encodes) of FLP recombinase in FRT
4) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0 Pain Relevance 0.03
In summary, HCV F protein, the alternative reading product of the viral genome, is expressed during the chronic viral infection that stimulates specific immune responses in vivo.
Gene_expression (expressed) of F protein associated with viral infection and hepatitis c virus infection
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.54 Pain Relevance 0
Although the F protein induced potent CD4+ T cell responses with defined epitopes in HLA-transgenic mice, these specific T cell responses were less obvious in HCV chronically infected patients.
Gene_expression (induced) of F protein in T cell associated with targeted disruption and hepatitis c virus infection
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.68 Pain Relevance 0
Expression of the F protein was studied with gWiz-F, a plasmid bearing the chimeric F gene under the control of cytomegalovirus early gene promoter.
Gene_expression (Expression) of F protein associated with cytomegalovirus infection
7) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.60 Pain Relevance 0
The HCV F protein-coding sequence was achieved by the +1/?
Gene_expression (The) of F protein associated with hepatitis c virus infection
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.90 Pain Relevance 0.06
F protein elicited specific CD4+ T cell response in chronic infected patients
Gene_expression (elicited) of F protein in T cell
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.86 Pain Relevance 0
After transient transfection of gWiz-F to human hepatoma cell line Huh 7, the expression of HCV F protein was identified in cell lysates with its expected size (25 KDa) by western blot using specific anti-HCV core and anti- HCV F antibodies (Fig. 1).
Gene_expression (expression) of F protein associated with hepatocellular cancer and hepatitis c virus infection
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.74 Pain Relevance 0
Bain and colleagues previously identified a specific CD8+ T cell response against the HCV F protein which was expressed from an alternate reading frame of the viral genome during HCV natural infection [19].
Gene_expression (expressed) of F protein in T cell associated with hepatitis c virus infection and infection
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 1.05 Pain Relevance 0.07
In this study, we constructed the gWiz-F as a fusion gene vector which could produce the F protein in eukaryotic cells as indicated by western blot assay. gWiz-F was further applied by DNA vaccination which made it possible to assess the immune activity of F protein in HLA-transgenic mice in vivo.
Gene_expression (produce) of F protein in eukaryotic cells associated with targeted disruption
12) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997803 Disease Relevance 0.94 Pain Relevance 0.03

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