INT42378

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Context Info
Confidence 0.67
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 15.81
Pain Relevance 5.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Socs3) cytoplasm (Socs3)
Anatomy Link Frequency
macrophages 3
liver 1
epithelium 1
fibroblasts 1
lamina 1
Socs3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 484 100.00 Very High Very High Very High
Inflammation 497 99.30 Very High Very High Very High
rheumatoid arthritis 73 98.68 Very High Very High Very High
Inflammatory stimuli 6 98.48 Very High Very High Very High
fibrosis 133 98.20 Very High Very High Very High
Inflammatory response 45 98.16 Very High Very High Very High
antagonist 13 97.24 Very High Very High Very High
Crohn's disease 9 92.32 High High
Inflammatory mediators 18 85.32 High High
Paracetamol 11 77.84 Quite High
Disease Link Frequency Relevance Heat
Injury 39 99.90 Very High Very High Very High
INFLAMMATION 537 99.30 Very High Very High Very High
Pulmonary Fibrosis 89 99.04 Very High Very High Very High
Rheumatoid Arthritis 73 98.68 Very High Very High Very High
Cancer 554 98.48 Very High Very High Very High
Sepsis 20 98.36 Very High Very High Very High
Colitis 33 98.32 Very High Very High Very High
Fibrosis 54 98.20 Very High Very High Very High
Keratitis 38 97.80 Very High Very High Very High
Candida Infection 28 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SOCS3 was also upregulated in the COX-2-/- mice compared to COX-2+/+ mice after LPS.
Positive_regulation (upregulated) of SOCS3
1) Confidence 0.67 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.54 Pain Relevance 0.37
STAT3 activation and high SOCS3 expression levels have been found in epithelial and lamina propria cells in the colon of IBD (inflammatory bowel disease) model mice, as well as in human ulcerative colitis and patients with Crohn's disease [76], and in synovial fibroblasts of patients with RA [77].
Positive_regulation (activation) of SOCS3 in lamina associated with inflammatory bowel disease, crohn's disease, inflammation, rheumatoid arthritis and disease
2) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.85 Pain Relevance 0.57
Interestingly, conditional STAT3 deletion in neutrophils also exhibited hyper-responses to G-CSF [48], suggesting that a major role of STAT3 in neutrophils is the induction of SOCS3.
Positive_regulation (induction) of SOCS3 in neutrophils
3) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.58 Pain Relevance 0.08
In a dextran sulfate sodium-induced mouse colitis model, a time-course experiment indicated that STAT3 activation was 1 day ahead of SOCS3 induction; STAT3 activation became apparent during days 3 to 5 and decreased thereafter, whereas SOCS3 expression was induced at day 5 and maintained high levels thereafter.
Positive_regulation (induction) of SOCS3 associated with colitis
4) Confidence 0.57 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 1.66 Pain Relevance 0.50
This sequence of molecular events is associated with a marked induction of SOCS1, SOCS2, SOCS3, as well as cytokine-induced Src homology 2-containing protein expression.
Positive_regulation (induction) of SOCS3 associated with cytokine
5) Confidence 0.52 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.14 Pain Relevance 0.09
Activation of STAT3 began on time at 3 hours but persisted strongly up to 72 hours despite significant accumulation of SOCS3.
Positive_regulation (accumulation) of SOCS3
6) Confidence 0.50 Published 2006 Journal Hepatology Section Abstract Doc Link 17133485 Disease Relevance 0.52 Pain Relevance 0.07
Activation of STAT1 that is harmful in liver injury was augmented in SOCS3Tg hepatocytes.
Positive_regulation (augmented) of SOCS3Tg in liver associated with injury
7) Confidence 0.49 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.83 Pain Relevance 0.43
SOCS3 mRNA up-regulation in the COX-2 deficient mice can thus be viewed as the consequence of the higher cytokine production in these mice after LPS.
Positive_regulation (up) of SOCS3 mRNA associated with cytokine
8) Confidence 0.45 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.53 Pain Relevance 0.46
Similarly, sustained gp130 and Stat3 activation in Socs3-deficient macrophages triggers a strong anti-inflammatory response [41-43] and expression of the canonical TGF?
Positive_regulation (activation) of Socs3 in macrophages associated with inflammatory response
9) Confidence 0.43 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.86 Pain Relevance 0.36
and IL6 responses appeared to be similar in the knockouts as judged by a comparable induction of the known feedback regulators of the major cytokine and growth factor signaling pathways such as SOCS3, IGFR1, DUSP1 and DUSP 6.
Positive_regulation (induction) of SOCS3 associated with cytokine
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940888 Disease Relevance 0 Pain Relevance 0.05
Others have shown that IL-6 strongly activates STAT1 and induces the expression of IFN-responsive genes in SOCS3-deficient macrophages, implying that IL-6 might mimic the action of IFNs [44,45].
Positive_regulation (genes) of SOCS3 in macrophages
11) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.48 Pain Relevance 0.25
Combination of the two receptor antagonists produced a greater degree of blockade than either alone and, at the maximum frequency utilized (32 Hz), the contractile response did not reach the EF10 in al tissues.
Neg (not) Positive_regulation (reach) of EF10 associated with antagonist
12) Confidence 0.40 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6262097 Disease Relevance 0 Pain Relevance 0.23
Conversely, excessive Stat3 activation, through epithelial-specific Socs3 ablation or introduction of the Socs3-binding deficient gp130Y757F mutation, results in increased tumour burden both in terms of tumour size as well as incidence [68,85].
Positive_regulation (activation) of Socs3 associated with cancer
13) Confidence 0.40 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.19 Pain Relevance 0.13
Sustained activation of Stat3 in (intestinal) epithelium, brought about by activation of the Socs3-unresponsive IL10R, IL22R or gp130Y757F receptors, induces an anti-microbial response.
Positive_regulation (activation) of Socs3-unresponsive in epithelium
14) Confidence 0.40 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 1.11 Pain Relevance 0.16
Overexpression of SOCS3 by adenovirus can prevent mouse RA models [77].
Positive_regulation (Overexpression) of SOCS3 associated with rheumatoid arthritis
15) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.81 Pain Relevance 0.12
SOCS1 and SOCS3 were found to be induced by LPS or CpG-DNA stimulation in macrophages [59-61].
Positive_regulation (induced) of SOCS3 in macrophages
16) Confidence 0.38 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.85 Pain Relevance 0.23
2, SOCS3, and other genes were induced exclusively by hyaluronan.
Positive_regulation (induced) of SOCS3
17) Confidence 0.24 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.31 Pain Relevance 0.27
Several authors (Kovarik et al 2005; Stark and Cross 2006) found that SOCS-1 and SOCS-3 are induced by cytokines such as IFN?
Positive_regulation (induced) of SOCS-3 associated with cytokine
18) Confidence 0.21 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 0.37 Pain Relevance 0.46
The three MAPKs activated in fibroblasts in the lung tissues of idiopathic pulmonary fibrosis may participate in the fibrogenesis of lung tissue [14].
Positive_regulation (activated) of fibroblasts in lung associated with fibrosis and pulmonary fibrosis
19) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.68 Pain Relevance 0.29
Akt phosphorylation is elevated in fibroblasts isolated from the lungs of bleomycin-injured mice.
Positive_regulation (elevated) of fibroblasts in fibroblasts
20) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 0.69 Pain Relevance 0.28

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