INT4239

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Context Info
Confidence 0.40
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 10.92
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T-cell 2
synovial fluid 1
CSF 1
AMs 1
eosinophils 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 146 100.00 Very High Very High Very High
rheumatoid arthritis 126 100.00 Very High Very High Very High
Inflammatory mediators 6 100.00 Very High Very High Very High
chemokine 84 99.98 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 9 99.92 Very High Very High Very High
dexamethasone 4 99.70 Very High Very High Very High
Angina 14 99.56 Very High Very High Very High
Inflammation 139 98.04 Very High Very High Very High
corticosteroid 19 97.48 Very High Very High Very High
Multiple sclerosis 43 97.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 166 100.00 Very High Very High Very High
Rheumatoid Arthritis 126 100.00 Very High Very High Very High
Thrombocytopenia 30 99.80 Very High Very High Very High
Cv General 3 Under Development 15 99.56 Very High Very High Very High
Myocardial Infarction 14 99.48 Very High Very High Very High
Cardiovascular Disease 12 98.68 Very High Very High Very High
Disease 166 98.60 Very High Very High Very High
Demyelinating Disease 45 97.40 Very High Very High Very High
Pulmonary Disease 116 97.24 Very High Very High Very High
Arthritis 29 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the same conditions, dexamethasone significantly inhibited the release both of TNF-alpha and RANTES by AMs, mainly acting at the mRNA level, but had no effect on ICAM-1 expression.
Negative_regulation (inhibited) of RANTES in AMs associated with dexamethasone
1) Confidence 0.40 Published 1998 Journal Transpl. Immunol. Section Abstract Doc Link 9848225 Disease Relevance 0.37 Pain Relevance 0.34
PDMP and RANTES levels were significantly decreased after PTCA (PDMP, p < 0.001; RANTES, p < 0.05), but without differences between the two groups.
Negative_regulation (decreased) of RANTES associated with percutaneous transluminal coronary angioplasty
2) Confidence 0.36 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12624635 Disease Relevance 0.79 Pain Relevance 0.54
We measured interleukin-1beta, interleukin-6, interferon-gamma inducible protein-10, RANTES (regulated upon activation, normal T-cell expressed and secreted), complement C3, mannose-binding lectin, complement C1q, soluble intercellular adhesion molecule-1, endothelin-1, nitric oxide, human lactoferrin, and hypocretin-1 levels in these samples.
Negative_regulation (measured) of RANTES in T-cell
3) Confidence 0.26 Published 2008 Journal Clin J Pain Section Body Doc Link 18180633 Disease Relevance 0.19 Pain Relevance 0
Genes downregulated in JRA neutrophils relative to healthy controls (Table 2) included the immune and inflammatory mediators CCL3, CCL4, CCL5, IL-1B, COX-2, MHC-II DR-?
Negative_regulation (downregulated) of CCL5 in neutrophils associated with inflammatory mediators and rheumatoid arthritis
4) Confidence 0.25 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779452 Disease Relevance 0.98 Pain Relevance 0.44
As observed above, ICAM-1, IL-6, IL-8, GM-CSF, RANTES, MCP-1, GROalpha, NAP-2, and ENA-78 expression was reduced by the IKK inhibitors.
Negative_regulation (reduced) of RANTES
5) Confidence 0.19 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16687566 Disease Relevance 0.42 Pain Relevance 0.41
Inhibition of cytokines involved in the recruitment of eosinophils, such as IL-5, RANTES, and eotaxin could also be a strategy to modify inflammation during COPD exacerbations.
Negative_regulation (Inhibition) of RANTES in eosinophils associated with pulmonary disease, inflammation and cytokine
6) Confidence 0.19 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.69 Pain Relevance 0.36
However, a significant and time-dependent decrease in RANTES levels were observed in the non-restenosis group, and patients with restenosis compared with patients without restenosis had a statistically significant ratio of elevated levels of RANTES.
Negative_regulation (decrease) of RANTES associated with cardiovascular disease
7) Confidence 0.14 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 1.17 Pain Relevance 0.35
and IL-6 and a decreased level in RANTES (Figure 3b).
Negative_regulation (decreased) of RANTES
8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.70 Pain Relevance 0.16
RANTES level was also significantly decreased after treatment, but MCP-1 level was not changed.
Negative_regulation (decreased) of RANTES
9) Confidence 0.09 Published 2002 Journal Clin. Appl. Thromb. Hemost. Section Abstract Doc Link 12361207 Disease Relevance 0.97 Pain Relevance 0.47
Thus, as mentioned above for EGF, thrombocytopenia can also reduce levels of circulating RANTES.
Negative_regulation (reduce) of RANTES associated with thrombocytopenia
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 1.17 Pain Relevance 0.13
and IL-6, and a decrease in RANTES respectively were associated with disease severity (Figure 3a).
Negative_regulation (decrease) of RANTES associated with disease
11) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.34 Pain Relevance 0.22
On the contrary, T cell chemokine RANTES levels were significantly suppressed in severe CHIKF patients.
Negative_regulation (suppressed) of RANTES in T cell associated with chemokine
12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 1.08 Pain Relevance 0.15
This was attributed to an increase in the gradient between LVEDP and aortic diastolic pressure resulting from reduced venous return after SISD.
Negative_regulation (reduced) of SISD
13) Confidence 0.06 Published 1976 Journal Angiology Section Abstract Doc Link 1053551 Disease Relevance 0.42 Pain Relevance 0.36
Although CD19+ B-cell reduction occurs rapidly, recovery from the nadir is seen earlier and more pronounced compared with T cells.56–60 Recent evidence indicates that cladribine may also impede the influx of T cells into the CNS, and might also influence levels of soluble adhesion molecular levels such as sICAM or sE-Selectin.61,62 In addition, cladribine may exert immunomodulatory effects on proinflammatory cytokine profiles: Mean values of Interleukin-2 (IL-2) and soluble interleukin-2 receptor levels measured 12 months after cladribine treatment for chronic progressive MS were found to be lowered.63 IL-8-levels were decreased in cerebrospinal fluid (CSF) of cladribine-treated RRMS patients, whereas CCL-5 levels were decreased both in CSF and serum.64 These and other data suggests that cladribine not only has an leukocyte depleting effect, but also may exert a direct effect on effectors T-cell function.59,65

Pharmacokinetics of cladribine

Negative_regulation (decreased) of CCL-5 in CSF associated with multiple sclerosis, central nervous system, adhesions and cytokine
14) Confidence 0.03 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915536 Disease Relevance 0.46 Pain Relevance 0.24
In comparison with plasma, levels of MCP-1 (P = 0.008), IL-6 (P = 0.002), IL-8 (P = 0.002) and VEGF (P = 0.002) were elevated in synovial fluid, those of RANTES and ICAM-1 were decreased (P = 0.001 and P = 0.006, respectively), and GM-CSF concentrations were similar (P = 0.125).
Negative_regulation (decreased) of RANTES in synovial fluid
15) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174949 Disease Relevance 0.17 Pain Relevance 0.09

General Comments

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