INT42391

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Context Info
Confidence 0.49
First Reported 1981
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.93
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCR) signal transduction (BCR) plasma membrane (BCR)
kinase activity (BCR)
Anatomy Link Frequency
B-cell 2
blood 1
BCR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.36 Very High Very High Very High
Enkephalin 7 98.68 Very High Very High Very High
Endogenous opioid 4 97.60 Very High Very High Very High
tolerance 6 97.32 Very High Very High Very High
addiction 14 85.96 High High
rheumatoid arthritis 20 85.76 High High
Intracerebroventricular 1 83.60 Quite High
depression 15 81.76 Quite High
lidocaine 34 78.40 Quite High
narcan 5 68.80 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 44 99.34 Very High Very High Very High
Bartter Syndrome 15 98.48 Very High Very High Very High
Leukemia 94 96.80 Very High Very High Very High
Blast Crisis 3 91.60 High High
Drug Dependence 6 85.96 High High
Rheumatoid Arthritis 20 85.76 High High
Lymphatic System Cancer 53 84.84 Quite High
Anxiety Disorder 9 82.12 Quite High
Hodgkin's Disease 77 81.76 Quite High
Depression 19 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the chronic phase, interferon alfa-2 is more effective than cytotoxic chemotherapies but it also has more adverse effects. (2) Imatinib inhibits tyrosine kinase, an enzyme encoded by the pathological gene BCR-ABL, which is created during a reverse translocation between chromosomes 9 and 22 (characteristic of chronic myeloid leukaemia).
Positive_regulation (created) of BCR associated with leukemia
1) Confidence 0.49 Published 2003 Journal Prescrire Int Section Abstract Doc Link 12669727 Disease Relevance 0.49 Pain Relevance 0
We have complied with all applicable requirements of the international regulations, including ethic committee (Direction Générale de la Santé 2003/0259).
Positive_regulation (requirements) of all
2) Confidence 0.38 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137105 Disease Relevance 1.96 Pain Relevance 0
A breakdown of tolerance mechanisms that normally regulate B-cell development leads to the development of autoimmune diseases (William et al 2006), including induction and maintenance of self-reactive B-cell antigen receptor (BCR) complexes (Voulgarelis Dafni et al 1999; Dörner 2006; Dörner and Lipsky 2006; Martin and Chan 2006; Radbruch et al 2006).
Positive_regulation (induction) of BCR in B-cell associated with autoimmune disease and tolerance
3) Confidence 0.22 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.90 Pain Relevance 0.13
A breakdown of tolerance mechanisms that normally regulate B-cell development leads to the development of autoimmune diseases (William et al 2006), including induction and maintenance of self-reactive B-cell antigen receptor (BCR) complexes (Voulgarelis Dafni et al 1999; Dörner 2006; Dörner and Lipsky 2006; Martin and Chan 2006; Radbruch et al 2006).
Positive_regulation (maintenance) of BCR in B-cell associated with autoimmune disease and tolerance
4) Confidence 0.22 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376077 Disease Relevance 0.89 Pain Relevance 0.12
All ethical requirements for human subject research were followed, and approval from institutional ethics committee was obtained.
Positive_regulation (requirements) of All
5) Confidence 0.05 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC140309 Disease Relevance 0.59 Pain Relevance 0.16
We demonstrate for the first time that hypokalaemia disrupted these simple linear relationships and additionally significantly increased all values of ?
Positive_regulation (increased) of all associated with bartter syndrome
6) Confidence 0.02 Published 2007 Journal Pflugers Arch Section Body Doc Link PMC2627988 Disease Relevance 0.10 Pain Relevance 0.17
Effects of endogenous opioid peptides (leucine5-enkephalin; methionine5-enkephalin; and beta-endorphin) and morphine on isoleucine5-angiotensin II (All)-stimulated increase in plasma vasopressin concentration, blood pressure and drinking behavior were characterized in conscious rats.
Positive_regulation (increase) of All in blood associated with endogenous opioid, enkephalin and morphine
7) Confidence 0.01 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6262492 Disease Relevance 0 Pain Relevance 0.86

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