INT424

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Context Info
Confidence 0.61
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 15.04
Pain Relevance 10.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TSPO) mitochondrion (TSPO) aging (TSPO)
response to stress (TSPO)
Anatomy Link Frequency
monocyte 3
neural 2
nerve 2
pore 1
brain 1
TSPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Versed 8 100.00 Very High Very High Very High
parabrachial 8 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
diclofenac 48 99.98 Very High Very High Very High
analgesia 4 99.96 Very High Very High Very High
Morphine 4 99.76 Very High Very High Very High
pain suppression 32 99.48 Very High Very High Very High
dexamethasone 18 99.38 Very High Very High Very High
Pain 167 98.04 Very High Very High Very High
Inflammation 246 98.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bladder Disease 170 100.00 Very High Very High Very High
Necrosis 166 100.00 Very High Very High Very High
Anaphylaxis 33 99.76 Very High Very High Very High
Apoptosis 477 99.62 Very High Very High Very High
Pain 169 99.48 Very High Very High Very High
Epilepsy 2 98.44 Very High Very High Very High
INFLAMMATION 396 98.00 Very High Very High Very High
Overactive Bladder 133 97.60 Very High Very High Very High
Sprains And Strains 31 96.30 Very High Very High Very High
Hypertension 35 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors suggest that electrical stimulation of the PBR may be clinically applicable for treatment of human pain.
Positive_regulation (stimulation) of PBR associated with pain
1) Confidence 0.61 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 3871845 Disease Relevance 0.67 Pain Relevance 0.79
As a consequence, Labor abandoned their previous principled stand in the Senate of blocking the government's proposed increase in PBS copayments and safety-net thresholds [6] arguing that they needed the additional $1.1 billion to spend on election promises [7].
Spec (proposed) Positive_regulation (increase) of PBS
2) Confidence 0.60 Published 2005 Journal Aust New Zealand Health Policy Section Body Doc Link PMC548296 Disease Relevance 0 Pain Relevance 0
In 2003, as in 2002, the government proposed a 27% increase in PBS patient co-payments and safety-net thresholds in order to transfer more of the cost of the PBS from the government to consumers.
Positive_regulation (increase) of PBS
3) Confidence 0.60 Published 2005 Journal Aust New Zealand Health Policy Section Body Doc Link PMC548296 Disease Relevance 0.07 Pain Relevance 0
In 2003, as in 2002, the government proposed a 27% increase in PBS patient co-payments and safety-net thresholds in order to transfer more of the cost of the PBS from the government to consumers.
Positive_regulation (increase) of PBS
4) Confidence 0.60 Published 2005 Journal Aust New Zealand Health Policy Section Abstract Doc Link PMC548296 Disease Relevance 0.09 Pain Relevance 0
An endogenous factor stabilizing the benzodiazepine receptor could be lacking in the spontaneously epileptic baboon.
Positive_regulation (stabilizing) of benzodiazepine receptor associated with epilepsy
5) Confidence 0.42 Published 1979 Journal Epilepsia Section Abstract Doc Link 36275 Disease Relevance 0.25 Pain Relevance 0.17
Several benzodiazepines were shown to bind irreversibly to the receptor upon exposure to ultraviolet light and these agents can be used to facilitate solubilization and purification of the benzodiazepine receptor.
Positive_regulation (facilitate) of benzodiazepine receptor
6) Confidence 0.42 Published 1980 Journal Fed. Proc. Section Abstract Doc Link 6998742 Disease Relevance 0 Pain Relevance 0.17
The benzodiazepine receptor agonist, midazolam, concentration-dependently increased (by 58%, at 1 nmol/l) and decreased (by 32%, at 100 nmol/l) the release of 5-HT from small intestine preparations.
Positive_regulation (increased) of benzodiazepine receptor in small intestine associated with versed and agonist
7) Confidence 0.42 Published 1990 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1690357 Disease Relevance 0 Pain Relevance 0.50
Because of technical problems associated with the clinical use of microinjection techniques in the human brain, we investigated whether electrical stimulation of the PBR can produce pain suppression similar to pain suppression produced by cholinergic stimulation.
Positive_regulation (stimulation) of PBR in brain associated with pain suppression
8) Confidence 0.41 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 3871845 Disease Relevance 0.60 Pain Relevance 1.09
Since this suppression does not appear to involve neural systems that mediate morphine analgesia, stimulation of this pontine parabrachial region (PBR) may potentially be useful for control of human pain resistant or tolerant to opiate treatment.
Positive_regulation (stimulation) of PBR in neural associated with pain, opiate, parabrachial, analgesia and morphine
9) Confidence 0.41 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 3871845 Disease Relevance 0.48 Pain Relevance 0.96
These data indicate that electrical stimulation of the PBR, under certain stimulation parameters, can activate previously demonstrated neural populations related to pain suppression without affecting neural elements contributing to other behavioral or physiological functions.
Positive_regulation (stimulation) of PBR in neural associated with pain suppression
10) Confidence 0.41 Published 1985 Journal J. Neurosurg. Section Abstract Doc Link 3871845 Disease Relevance 0.69 Pain Relevance 1.08
A submerged MBR of approximately 21 L active volume equipped with two flat sheet membranes (A4 size, area 0.106 m2, pore size 0.4 ?
Positive_regulation (submerged) of MBR in pore
11) Confidence 0.40 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0 Pain Relevance 0.03
Another explanation could be greater adsorption potential of the MBR sludge, because the organic matter content is greater than for CAS sludge.
Positive_regulation (potential) of MBR
12) Confidence 0.40 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0 Pain Relevance 0.18
Previous studies conducted in adult patients [22,24,25] found that the increase in IBP was statistically significant with a small instillation volume, and two studies conducted in children and infants [37,38] found that the IAP is most accurately measured by instilling into the bladder 1 ml saline per kilogram of body weight.
Positive_regulation (increase) of IBP in body associated with body weight
13) Confidence 0.39 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.38 Pain Relevance 0
In the MBR the concentration of microorganisms can be increased to up to 20 mg L?
Positive_regulation (increased) of MBR
14) Confidence 0.37 Published 2006 Journal Anal Bioanal Chem Section Body Doc Link PMC1805043 Disease Relevance 0 Pain Relevance 0.04
The RPBS provides pharmaceutical benefits to veterans and eligible dependants that in general conform to the same requirements as for the PBS.
Positive_regulation (requirements) of PBS
15) Confidence 0.33 Published 2007 Journal Aust New Zealand Health Policy Section Body Doc Link PMC1828161 Disease Relevance 0.46 Pain Relevance 0.36
Removal rates of 26 and 56% were achieved for 4'-OH-DCF following CAS and MBR treatment, respectively.
Positive_regulation (following) of MBR associated with diclofenac
16) Confidence 0.26 Published 2008 Journal Anal. Chem. Section Abstract Doc Link 18821734 Disease Relevance 0.07 Pain Relevance 0.47
Benzodiazepines act via activation of the benzodiazepine receptor and probably share with barbiturates action at the GABA-benzodiazepine-chloride ionophore complex but do not produce their effects, directly or indirectly, by 5-hydroxytryptamine 1a receptor activation.
Positive_regulation (activation) of benzodiazepine receptor associated with gaba
17) Confidence 0.11 Published 1992 Journal Neuroscience Section Abstract Doc Link 1350666 Disease Relevance 0.14 Pain Relevance 0.42
A salient finding of the study was a five-fold increase of TRPM8-immunoreactive axons (ummyelinated fibres) in PBS as compared to controls.
Positive_regulation (increase) of PBS associated with bladder disease
18) Confidence 0.09 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 1.07 Pain Relevance 0.83
In addition, an increase in TRPM8-immunoreactive nerve fibres in IDO and PBS, suggests that TRPM8 may contribute to the increased frequency which is a prominent symptom in these conditions.
Positive_regulation (increase) of PBS in nerve associated with bladder disease
19) Confidence 0.09 Published 2006 Journal BMC Urol Section Body Doc Link PMC1420318 Disease Relevance 0.65 Pain Relevance 0.20
Caspase-9 activation was quite similar in both PBS and HMW-HA treatments, except at the dose 75 mJ/cm2 of UVB, which indicated a significant caspase-9 decrease (?
Positive_regulation (activation) of PBS
20) Confidence 0.09 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2660376 Disease Relevance 0.20 Pain Relevance 0

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