INT4240

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Context Info
Confidence 0.58
First Reported 1976
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 20.55
Pain Relevance 10.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CCL5) aging (CCL5) extracellular region (CCL5)
cell-cell signaling (CCL5) cytoplasm (CCL5)
Anatomy Link Frequency
T-cell 6
blood 2
macrophages 2
fibroblasts 2
peritoneal fluid 1
CCL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 836 100.00 Very High Very High Very High
chemokine 682 100.00 Very High Very High Very High
cytokine 334 100.00 Very High Very High Very High
Opioid 7 99.98 Very High Very High Very High
endometriosis 272 99.96 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 9 99.44 Very High Very High Very High
Arthritis 414 97.68 Very High Very High Very High
Angina 22 96.96 Very High Very High Very High
rheumatoid arthritis 134 94.84 High High
substance P 27 93.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 893 100.00 Very High Very High Very High
Endometriosis 358 100.00 Very High Very High Very High
Acid Reflux 18 99.64 Very High Very High Very High
Infection 101 99.40 Very High Very High Very High
Cardiovascular Disease 12 99.16 Very High Very High Very High
Myocardial Infarction 13 98.64 Very High Very High Very High
Acute Coronary Syndrome 3 98.56 Very High Very High Very High
Hypersensitivity 13 98.16 Very High Very High Very High
Asthma 124 97.80 Very High Very High Very High
Arthritis 116 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells.
Positive_regulation (induction) of RANTES in blood associated with opioid
1) Confidence 0.58 Published 2000 Journal J. Immunol. Section Title Doc Link 11086093 Disease Relevance 0.60 Pain Relevance 0.71
Previous studies have demonstrated that RANTES (regulated on activation, normal T cell expressed and secreted) is synthesized by endometriotic stromal cells and circulates in peritoneal fluid, commensurate with the stage of endometriosis.
Positive_regulation (circulates) of RANTES in T cell associated with endometriosis
2) Confidence 0.49 Published 2001 Journal Mol. Hum. Reprod. Section Abstract Doc Link 11160842 Disease Relevance 0.64 Pain Relevance 0.27
The addition of Brefeldin A or monensin to unstimulated cultures did not increase the amount of CCL5 detected (data not shown).
Neg (not) Positive_regulation (increase) of CCL5
3) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.16 Pain Relevance 0.20
We demonstrate that the chemokines CCL5 (RANTES) and CCL3 (also known as macrophage inflammatory protein (MIP)-1?)
Positive_regulation (chemokines) of RANTES in macrophage associated with chemokine and inflammation
4) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 1.09 Pain Relevance 0.71
Most studies have focussed on inflammatory chemokines that promote monocyte migration, primarily MCP-1 and also RANTES (regulated upon activation, normally T cell-expressed and presumably secreted) [15-17].
Positive_regulation (promote) of RANTES in T cell associated with chemokine and inflammation
5) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2626602 Disease Relevance 1.61 Pain Relevance 0.74
Finally, elevated CCL5 and CCL18 levels predicted future cardiovascular adverse events, whereas C-reactive protein and sCD40L levels did not.
Positive_regulation (elevated) of CCL5
6) Confidence 0.45 Published 2007 Journal Circulation Section Body Doc Link 17909104 Disease Relevance 0 Pain Relevance 0
The other 20 upregulated genes encoded growth factors (VEGF, DTR/HB-EGF, IGFBP7, IL-6, ANGPT2, EREG, CCL3/MIP1A, and CCL5/RANTES) or growth factor receptors (TBXA2R, TNFRSF10A/ TRAILR1, and ROBO2), mainly involved in angiogenesis.
Positive_regulation (upregulated) of RANTES
7) Confidence 0.45 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.15 Pain Relevance 0.08
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Positive_regulation (inflammatory) of CCL5 associated with chemokine and inflammation
8) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.68 Pain Relevance 0.43
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Positive_regulation (inflammatory) of RANTES associated with chemokine and inflammation
9) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.69 Pain Relevance 0.43
Levels of mRNA of the three inflammatory chemokines CCL5 (RANTES), CCL3 (MIP-1?)
Positive_regulation (chemokines) of RANTES associated with chemokine and inflammation
10) Confidence 0.42 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.68 Pain Relevance 0.43
All three of these chemokines are highly expressed at the level of mRNA, with the most significant increase in mRNA levels being demonstrated for CCL5 when compared with matched peripheral blood samples and controls.
Positive_regulation (increase) of CCL5 in blood associated with chemokine
11) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1526593 Disease Relevance 0.60 Pain Relevance 0.52
Synovial CD8+ T cells also contained high levels of the protein CCL5, which was readily detected by intracellular staining, although no increased detection was seen with the use of ER blockade.
Neg (no) Positive_regulation (increased) of protein CCL5 in T cells
12) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.47 Pain Relevance 0.30
This showed a significant increase in the CCL5 positive cells within this CD8+CD28+ population in the synovial T cells compared to PB (Figure 5c).
Positive_regulation (increase) of CCL5 in T cells
13) Confidence 0.39 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526593 Disease Relevance 0.22 Pain Relevance 0.11
Our ELISA method appears to be sufficient for monitoring PDMP and RANTES levels after PTCA in patients with acute coronary syndrome.
Spec (appears) Positive_regulation (sufficient) of RANTES associated with acute coronary syndrome and percutaneous transluminal coronary angioplasty
14) Confidence 0.38 Published 2003 Journal Thromb. Haemost. Section Abstract Doc Link 12624635 Disease Relevance 0.79 Pain Relevance 0.45
Recent reports suggest that CSF levels of CCL5 are increased in NPSLE patients compared with non-NPSLE patients [21].

3.1.2.

Positive_regulation (increased) of CCL5
15) Confidence 0.34 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.66 Pain Relevance 0.53
In fact, we observed cell type specific gene changes such as IL-8, PAI-1 and RANTES that were upregulated in the cell lines but not the patient samples while the anti-inflammatory cytokine IL-10 was upregulated in the patient samples but not the cell lines, indicative of the effects of multiple cell types in an in vivo system.
Positive_regulation (upregulated) of RANTES associated with inflammation and cytokine
16) Confidence 0.33 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 0.31 Pain Relevance 0.18
RANTES and IP-10 are strongly induced in dermal fibroblasts and synoviocytes stimulated by TWEAK
Positive_regulation (induced) of RANTES in fibroblasts
17) Confidence 0.27 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.09 Pain Relevance 0.12
However, a significant and time-dependent decrease in RANTES levels were observed in the non-restenosis group, and patients with restenosis compared with patients without restenosis had a statistically significant ratio of elevated levels of RANTES.
Positive_regulation (elevated) of RANTES associated with cardiovascular disease
18) Confidence 0.16 Published 2006 Journal Platelets Section Abstract Doc Link 17127484 Disease Relevance 1.16 Pain Relevance 0.38
which induced RANTES 17-fold and IP-10 6-fold).


Positive_regulation (induced) of RANTES
19) Confidence 0.16 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.06 Pain Relevance 0.11
Several studies have demonstrated that human ASM cells are also capable of expressing and secreting biologically active RANTES following stimulation with TNF-?
Positive_regulation (stimulation) of RANTES
20) Confidence 0.16 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.59 Pain Relevance 0.32

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