INT42415

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Context Info
Confidence 0.14
First Reported 1981
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cyb5d2) molecular_function (Cyb5d2) cellular_component (Cyb5d2)
biological_process (Cyb5d2)
Cyb5d2 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 1 98.98 Very High Very High Very High
Enkephalin 1 98.58 Very High Very High Very High
opiate 1 97.98 Very High Very High Very High
Serotonin 1 40.56 Quite Low
Inflammation 1 25.00 Low Low
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Immunization 1 100.00 Very High Very High Very High
Recurrence 2 99.48 Very High Very High Very High
Skin Cancer 3 98.64 Very High Very High Very High
Neuroblastoma 2 97.44 Very High Very High Very High
Disease 2 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of mouse neuroblastoma cell line N4TGl to opiates or [D-Ala2,D-Leu5] enkephalin produced a naloxone-reversible inhibition of cyclic AMP synthesis and prevented, in a concentration-dependent manner, the formation of both ganglioside GM2 (GalNAc-[NeuNAc]-Gal-Glc-ceramide) from GM3 (NeuNAc-Gal-Glc-ceramide) and ganglioside GM1 (Gal-GalNAc-[NeuNAc]-Gal-Glc-ceramide) from GM2 in cell-free extracts.
Negative_regulation (prevented) of GM2 Binding (formation) of associated with neuroblastoma, narcan, enkephalin and opiate
1) Confidence 0.14 Published 1981 Journal J. Neurochem. Section Abstract Doc Link 6265598 Disease Relevance 0.15 Pain Relevance 0.25
Oncol., 12: 1036-1044, 1994), we demonstrated that immunization with GM2 and bacille Calmette-Guerin reduced the risk of relapse in stage III melanoma patients who were free of disease after surgical resection and who had no preexisting anti-GM2 antibodies.
Negative_regulation (reduced) of GM2 Binding (immunization) of associated with immunization, disease, skin cancer and recurrence
2) Confidence 0.04 Published 2000 Journal Clin. Cancer Res. Section Abstract Doc Link 10741710 Disease Relevance 0.47 Pain Relevance 0

General Comments

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