INT4242

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Context Info
Confidence 0.58
First Reported 1975
Last Reported 1997
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 26
Disease Relevance 1.47
Pain Relevance 15.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 6
third ventricle 4
hypothalamus 2
arcuate nucleus 2
pituitary 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 100 100.00 Very High Very High Very High
opiate 11 100.00 Very High Very High Very High
Catecholamine 2 100.00 Very High Very High Very High
narcan 11 99.98 Very High Very High Very High
anesthesia 3 99.92 Very High Very High Very High
Potency 1 99.92 Very High Very High Very High
Somatostatin 28 99.84 Very High Very High Very High
antagonist 24 99.74 Very High Very High Very High
Morphine 14 99.12 Very High Very High Very High
agonist 14 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoglycemia 2 99.84 Very High Very High Very High
Stress 7 99.60 Very High Very High Very High
Immunization 2 98.82 Very High Very High Very High
Hypotension 4 93.56 High High
Urological Neuroanatomy 2 87.16 High High
Pressure Volume 2 Under Development 1 85.76 High High
Depression 1 64.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In two-day-old pups, clonidine had no effect on basal GH levels but, like yohimbine, prevented the increase in serum GH normally associated with nursing.
Negative_regulation (prevented) of Positive_regulation (increase) of GH associated with clonidine
1) Confidence 0.58 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.51
In eight-day-old pups, yohimbine prevented the nursing-induced increase in serum GH and decreased GH levels below the saline-injected, separated control.
Negative_regulation (prevented) of Positive_regulation (increase) of GH
2) Confidence 0.58 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.46
The inhibition of 5-HT synthesis by p-chlorophenylalanine also suppressed the secretory episode of GH seen in the morning and the release of GH induced by hypoglycaemia; both being partly restored in animals pretreated with 5-hydroxytryptamine.
Negative_regulation (suppressed) of Positive_regulation (induced) of GH associated with hypoglycemia
3) Confidence 0.57 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 7430898 Disease Relevance 0.20 Pain Relevance 0.53
The injection of yohimbine (3 mg/kg, i.p.) strongly inhibited the secretion of GH induced by clonidine treatment in sham-operated animals, and its inhibitory action was significantly attenuated in castrates.
Negative_regulation (inhibited) of Positive_regulation (induced) of GH associated with clonidine
4) Confidence 0.56 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2154719 Disease Relevance 0.41 Pain Relevance 0.77
The alpha 2A- and alpha 1-selective adrenoceptor antagonist, WB-4101 (2-(2,6-dimethoxyphenoxyethyl)-aminomethyl-1,4-benzodioxane hydrochloride), prevented the GH rise normally induced by oxymetazoline while prazosin, the alpha 2B- and alpha 1-selective adrenoceptor antagonist, prolonged the elevation occurring in the control rats between 30 and 60 min after oxymetazoline injection.
Negative_regulation (prevented) of Positive_regulation (induced) of GH associated with antagonist
5) Confidence 0.56 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8666024 Disease Relevance 0 Pain Relevance 0.38
Yohimbine did not affect serum GH levels in separated two-day-old pups (i.e. basal levels of the hormone), but prevented the nursing-induced increase in serum GH concentration.
Negative_regulation (prevented) of Positive_regulation (increase) of GH
6) Confidence 0.43 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.50
In rats chronically treated with yohimbine (2 mg/kg i.p. 2-3 times daily for 14 days until sacrifice), the GH response to a high dose of clonidine (0.5 mg/kg i.p.) was blocked, while the effect of morphine (5 mg/kg s.c.) was significantly enhanced.
Negative_regulation (blocked) of Positive_regulation (response) of GH associated with morphine and clonidine
7) Confidence 0.41 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1678497 Disease Relevance 0 Pain Relevance 1.31
The ability of 5-hydroxyl-L-tryptophan (5-HTP) or pentobarbital anesthesia to elevate rat serum GH levels is completely blocked by the simultaneous administration of the serotonin antagonist cyprophepatidine, as well as by the pineal gland principles melatonin and 5-methoxytryptamine (5-MT), and by the 0-methylated dopamine derivative 3,4-dimethoxyphenylethylamine (DMPEA).
Negative_regulation (blocked) of Positive_regulation (elevate) of GH in pineal gland associated with dopamine, anesthesia, antagonist and serotonin
8) Confidence 0.39 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1056508 Disease Relevance 0 Pain Relevance 0.24
The model used in testing this system was the capacity of ovine (o) GH, injected into the third ventricle, to suppress the endogenous GH surge induced by clonidine (CLON), an alpha 2-agonist.
Negative_regulation (suppress) of Positive_regulation (induced) of GH in third ventricle associated with agonist and clonidine
9) Confidence 0.39 Published 1989 Journal Endocrinology Section Abstract Doc Link 2571494 Disease Relevance 0 Pain Relevance 0.69
Intraventricular administration of beta-endorphin (5 microgram/rat) also increased the plasma GH levels which were lowered by phenoxybenzamine.
Negative_regulation (lowered) of Positive_regulation (increased) of GH in plasma
10) Confidence 0.38 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6117022 Disease Relevance 0 Pain Relevance 0.55
These results indicate that the pathway for opiate-induced stimulation of GH release is functional during stress, and suggest that the suppressive effect of stress does not involve a blockade of opiate receptor stimulation of GH.
Negative_regulation (blockade) of Positive_regulation (stimulation) of GH associated with stress and opiate
11) Confidence 0.38 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6473349 Disease Relevance 0.53 Pain Relevance 0.87
Pretreatment with reserpine (1 mg/100 g b.w., i.p.) abolished not only the natural GH burst but also the GH response to FK 33-824.
Negative_regulation (abolished) of Positive_regulation (response) of GH
12) Confidence 0.38 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6117022 Disease Relevance 0 Pain Relevance 0.59
Pretreatment with dopamine-beta-hydroxylase inhibitors, diethyldithiocarbamate (DDC, 100 mg/100 g b.w., i.v.) and fusarate (10 mg/100 g b.w., i.v.) also inhibited the natural GH burst and GH rise induced by FK 33-824.
Negative_regulation (inhibited) of Positive_regulation (induced) of GH associated with dopamine
13) Confidence 0.38 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6117022 Disease Relevance 0 Pain Relevance 0.62
Pretreatment with reserpine (1 mg/100 g b.w., i.p.) abolished not only the natural GH burst but also the GH response to FK 33-824.
Negative_regulation (abolished) of Positive_regulation (response) of GH
14) Confidence 0.38 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6117022 Disease Relevance 0 Pain Relevance 0.59
The depressed response of GH to clonidine after puberty may be attributable to a combination of the trends toward decreased sensitivity of both SRIF and GRF at this age.
Negative_regulation (depressed) of Positive_regulation (response) of GH associated with clonidine
15) Confidence 0.38 Published 1997 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9267532 Disease Relevance 0.06 Pain Relevance 0.70
The plasma GH increase induced by FK 33-824 was blunted by a specific opiate antagonist, naloxone (125 micrograms/100 g BW, iv), and the following spontaneous GH bursts occurred at the same time as in controls.
Negative_regulation (blunted) of Positive_regulation (increase) of GH in plasma associated with antagonist, narcan and opiate
16) Confidence 0.37 Published 1981 Journal Endocrinology Section Abstract Doc Link 7285858 Disease Relevance 0 Pain Relevance 0.69
GH preinjected 1 or 3 h before clonidine significantly suppressed the clonidine-induced GH surge, whereas TSH release was not affected by GH.
Negative_regulation (suppressed) of Positive_regulation (clonidine-induced) of GH associated with clonidine
17) Confidence 0.36 Published 1985 Journal Endocrinology Section Abstract Doc Link 2866085 Disease Relevance 0.08 Pain Relevance 0.65
Passive immunization with 400 microliters sheep antisomatostatin serum did not reverse the inhibition of the clonidine-induced GH surge by exogenous GH administered IVT either 1 or 3 h before clonidine.
Neg (not) Negative_regulation (reverse) of Positive_regulation (clonidine-induced) of GH in IVT associated with immunization and clonidine
18) Confidence 0.36 Published 1985 Journal Endocrinology Section Abstract Doc Link 2866085 Disease Relevance 0.10 Pain Relevance 0.70
To characterize the mechanisms underlying the inhibition of GH secretion by HA, the effect of HA on GH induced by CLO was examined in rats depleted of catecholamine by pretreatment (2 h before) with alpha-methyl-p-tyrosine (alpha-MpT, 200 mg/kg s.c.) and in rats depleted of somatostatin by pretreatment (4 h before) with cysteamine (300 mg/kg s.c.).
Negative_regulation (depleted) of Positive_regulation (induced) of GH associated with catecholamine, somatostatin and clonidine
19) Confidence 0.33 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 7901783 Disease Relevance 0 Pain Relevance 0.75
These data suggest that an intact 5HT system is required for alpha 2-stimulated GH release. 5,7-DHT neurotoxin microinjected into the midline arcuate nucleus (6 micrograms/mg,iv) or bilaterally into the ventromedial nucleus or perifornical area (4 micrograms/0.2 microliter) 5 days previously suppressed the CLON (30 micrograms/kg)-induced GH surge only in animals with arcurate nucleus lesions.
Negative_regulation (suppressed) of Positive_regulation (-induced) of GH in arcuate nucleus associated with 5ht and clonidine
20) Confidence 0.32 Published 1990 Journal Endocrinology Section Abstract Doc Link 1688789 Disease Relevance 0 Pain Relevance 0.65

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