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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.80
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adrb1) plasma membrane (Adrb1) nucleus (Adrb1)
cytoplasm (Adrb1) signal transducer activity (Adrb1)
Anatomy Link Frequency
brain 2
Adrb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 3 99.76 Very High Very High Very High
antidepressant 3 99.24 Very High Very High Very High
opiate 2 99.24 Very High Very High Very High
Dopamine 3 98.44 Very High Very High Very High
5HT 2 98.28 Very High Very High Very High
Serotonin 1 84.28 Quite High
noradrenaline 1 83.28 Quite High
Neurotransmitter 1 75.00 Quite High
monoamine 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Shock 6 99.84 Very High Very High Very High
Urological Neuroanatomy 3 95.76 Very High Very High Very High
Convulsion 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects were compared to those of the standard antidepressants imipramine and fluoxetine. [125I]CYP binding to beta-AR was found to be decreased after short as well as after long-term treatment with imipramine (36%, 40%).
Negative_regulation (decreased) of beta-AR Binding (binding) of associated with antidepressant and fluoxetine
1) Confidence 0.58 Published 2004 Journal Life Sci. Section Abstract Doc Link 14672758 Disease Relevance 0.17 Pain Relevance 0.40
Binding of the beta-receptor ligand dihydroalprenolol (3H-DHA) was significantly reduced in ECS-treated rat brain membranes.
Negative_regulation (reduced) of beta-receptor Binding (Binding) of in brain associated with shock
2) Confidence 0.33 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6265964 Disease Relevance 0.62 Pain Relevance 0.57

General Comments

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