INT42425

Context Info Confidence 0.75 First Reported 1981 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.68 Pain Relevance 0.91

endosome (Mmd)

Mmd (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 5 100.00 opiate 3 97.84 analgesia 2 94.16 Analgesic 2 75.00 agonist 4 59.36 headache 2 7.28 imagery 6 5.00 Inflammation 2 5.00 antagonist 2 5.00

Disease Link Frequency Relevance Heat Disease 170 100.00 Ophthalmoplegia 22 99.80 Contracture 6 95.32 Scoliosis 10 91.20 Epstein-barr Virus 2 80.80 Cardiomyopathy 12 76.48 Frailty 12 66.12 Central Core Disease 62 60.48 Hypersensitivity 2 56.48 Malignant Hyperthermia 30 53.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It was also discovered that pentagastrin, MAF and enkephalins produce a different action on metabolism of biogenic amines.

Gene_expression (produce) of MAF associated with enkephalin

1) Confidence 0.75 Published 1981 Journal Biull Eksp Biol Med Section Abstract Doc Link 6266552 Disease Relevance 0 Pain Relevance 0.88

E-C uncoupling was also indicated by complete loss of Ca2+ conductance in recombinant mutant RyR1 channels expressing a Arg109Trp substitution [53] previously associated with a MmD and ophthalmoplegia phenotype [17].

Gene_expression (expressing) of MmD associated with ophthalmoplegia and disease

2) Confidence 0.18 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1947955 Disease Relevance 0.88 Pain Relevance 0.03

Marked axial involvement is common, particularly in the classic form of MmD secondary to SEPN1 mutations, and exercises promoting truncal stability such as swimming and riding [79] may be particularly recommended.

Gene_expression (mutations) of MmD associated with disease

3) Confidence 0.18 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1947955 Disease Relevance 0.80 Pain Relevance 0

General Comments

This test has worked.