INT42459

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Context Info
Confidence 0.25
First Reported 1981
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 13.49
Pain Relevance 12.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 4
neuronal 2
LRF 2
tail 2
lateral areas 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 312 100.00 Very High Very High Very High
Endocannabinoid 56 100.00 Very High Very High Very High
antagonist 43 100.00 Very High Very High Very High
depression 2 100.00 Very High Very High Very High
Morphine 232 99.98 Very High Very High Very High
Central nervous system 9 99.60 Very High Very High Very High
midbrain 20 98.88 Very High Very High Very High
Antinociceptive 32 98.48 Very High Very High Very High
Neurotransmitter 13 98.40 Very High Very High Very High
withdrawal 19 98.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 489 100.00 Very High Very High Very High
Depression 2 100.00 Very High Very High Very High
Anxiety Disorder 188 99.92 Very High Very High Very High
Stress 33 99.56 Very High Very High Very High
Body Weight 8 95.44 Very High Very High Very High
Nociception 72 94.24 High High
Inflammatory Pain 13 92.32 High High
Pain 102 92.20 High High
Agoraphobia 3 88.16 High High
Sleep Disorders 85 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrate a significant increase in NR2B expression in the lateral areas of the PAG (LPAG).
Positive_regulation (increase) of Gene_expression (expression) of PAG in lateral areas associated with central grey
1) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.07 Pain Relevance 1.31
These results underscore the importance of vlPAG neurons in regulating REM sleep.
Positive_regulation (importance) of Gene_expression (neurons) of vlPAG in neurons
2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.39 Pain Relevance 0.21
Thus, the vlPAG lesion caused the FVB-GFP mice to be awake more during the day.
Positive_regulation (caused) of Gene_expression (lesion) of vlPAG
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.23 Pain Relevance 0
increase in DOR density in the plasma membrane of PAG neurons [14].
Positive_regulation (increase) of Gene_expression (neurons) of PAG in neurons associated with urological neuroanatomy
4) Confidence 0.24 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.90 Pain Relevance 1.56
Microinjection of deltorphin into the PAG caused a modest, but significant,
Positive_regulation (caused) of Gene_expression (Microinjection) of PAG associated with urological neuroanatomy
5) Confidence 0.24 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.10 Pain Relevance 0.63
morphine microinjection into the vPAG appears to be part of a defensive
Spec (appears) Positive_regulation (appears) of Gene_expression (microinjection) of vPAG associated with morphine
6) Confidence 0.24 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 0.51 Pain Relevance 1.53
The results suggest pharmacologically distinct mechanisms of inhibition produced by stimulation in PAG and LRF.
Positive_regulation (stimulation) of Gene_expression (produced) of PAG in LRF associated with central grey
7) Confidence 0.18 Published 1981 Journal Pain Section Abstract Doc Link 6267541 Disease Relevance 0.47 Pain Relevance 0.33
To determine whether neuronal activation may be involved in the stress-induced microglial activation, the present study investigated the correlation between neuronal activity measured as c-Fos expression and morphological microglial activation in the PAG.
Positive_regulation (activation) of Gene_expression (expression) of PAG in neuronal associated with stress and central grey
8) Confidence 0.17 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19111355 Disease Relevance 1.16 Pain Relevance 0.42
Acute stress was followed by morphological activation of microglia and increased c-Fos expression in the PAG but not in the surrounding midbrain.
Positive_regulation (increased) of Gene_expression (expression) of PAG in midbrain associated with stress, midbrain and central grey
9) Confidence 0.17 Published 2009 Journal J. Neuroimmunol. Section Abstract Doc Link 19111355 Disease Relevance 1.15 Pain Relevance 0.43
Urinary profiles of HBF mice showed lower levels of PAG, tryptamine and an unknown metabolite (U1), and higher levels of ?
Positive_regulation (lower) of Gene_expression (levels) of PAG associated with urological neuroanatomy
10) Confidence 0.15 Published 2007 Journal Mol Syst Biol Section Body Doc Link PMC2673711 Disease Relevance 0.16 Pain Relevance 0.12
encroaching upon this latter PAG region do not seem to affect the motivational
Positive_regulation (encroaching) of Gene_expression (region) of PAG associated with central grey
11) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.52 Pain Relevance 0.26
PAG, but they were based on large injection sites, providing just an overall
Positive_regulation (overall) of Gene_expression (overall) of PAG associated with central grey
12) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.81 Pain Relevance 0.48
encroaching upon this latter PAG region do not seem to affect the motivational
Positive_regulation (upon) of Gene_expression (region) of PAG associated with central grey
13) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2657915 Disease Relevance 0.52 Pain Relevance 0.26
In the caudal ventrolateral PAG, however,
Positive_regulation (however) of Gene_expression (however) of PAG associated with central grey
14) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.87 Pain Relevance 0.60
and the injection of NMDA antagonist receptors into the dlPAG promotes
Positive_regulation (promotes) of Gene_expression (injection) of dlPAG associated with antagonist
15) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.83 Pain Relevance 0.84
injected into the dlPAG increased the exploration of the open arms of the
Positive_regulation (increased) of Gene_expression (injected) of dlPAG in arms
16) Confidence 0.10 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2593468 Disease Relevance 0.74 Pain Relevance 0.56
These results suggest that PPE gene expression in the caudal PAG is stimulated in the recuperative phase of these morphine withdrawal signs.
Positive_regulation (stimulated) of Gene_expression (expression) of PAG associated with withdrawal, central grey and morphine
17) Confidence 0.09 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9582424 Disease Relevance 0.69 Pain Relevance 0.87
Although the depression of PAG-induced echolocation calls persisted beyond the end of the experimental session (140 min; Fig. 3A), elicitability from both PAG electrodes was fully recovered in the control experiments 24 hrs later.


Positive_regulation (induced) of Gene_expression (depression) of PAG associated with depression and urological neuroanatomy
18) Confidence 0.09 Published 2005 Journal BMC Biol Section Body Doc Link PMC1190161 Disease Relevance 0.78 Pain Relevance 0.05
This effect is in part related to the increased level of oxytocin in the periaquaductal gray (PAG), which can influence the descending antinociceptive system.15
Positive_regulation (periaquaductal) of Gene_expression (gray) of PAG associated with urological neuroanatomy and antinociceptive
19) Confidence 0.03 Published 2008 Journal Indian Journal of Nephrology Section Body Doc Link PMC2813537 Disease Relevance 0.91 Pain Relevance 1.01
We studied in healthy rats the effect of elevation of PAG endocannabinoid [anandamide and 2-arachidonoylglycerol (2-AG)] levels produced by intra-PAG injections of the inhibitor of fatty acid amide hydrolase URB597 [cyclohexylcarbamic acid-3'-carbamoyl-biphenyl-3-yl ester] on 1) nociception in the "plantar test" and 2) spontaneous and tail-flick-related activities of RVM neurons.
Positive_regulation (elevation) of Gene_expression (produced) of PAG in tail associated with nociception, endocannabinoid, tail-flick, central grey and rostral ventromedial medulla
20) Confidence 0.02 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16284279 Disease Relevance 0.69 Pain Relevance 0.75

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