INT42467

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Context Info
Confidence 0.02
First Reported 1981
Last Reported 1981
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.18

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plasma membrane (PTGER1, LNPEP) cytosol (LNPEP) peptidase activity (LNPEP)
extracellular region (LNPEP) intracellular (LNPEP) cell-cell signaling (LNPEP)
PTGER1 (Homo sapiens)
LNPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 1 97.52 Very High Very High Very High
aspirin 1 89.88 High High
Paracetamol 1 88.76 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PGE1, PGE2 and PGF2 alpha significantly inhibited serum oxytocinase activity in a dose-related manner and in decreasing order of potency. cGMP, 8-bromo-cGMP, indomethacin, polyphloretin phosphate, hypertonic saline and urea were also active. cAMP, db-cAMP, 8-bromo-cAMP, db-cGMP, 5'-AMP, 5'-ADP, 5'-ATP, 5'-GDP, 5'-GTP, aspirin, sodium salicylate, paracetamol, theophylline and IBMX did not inhibit the enzyme activity.
PGE1 Negative_regulation (inhibited) of oxytocinase associated with aspirin, paracetamol and potency
1) Confidence 0.02 Published 1981 Journal Prostaglandins Med Section Abstract Doc Link 6267639 Disease Relevance 0 Pain Relevance 0.18

General Comments

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