INT42497

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Context Info
Confidence 0.44
First Reported 1981
Last Reported 1997
Negated 1
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.63
Pain Relevance 1.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 2
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Action potential 1 100.00 Very High Very High Very High
tetrodotoxin 2 99.42 Very High Very High Very High
Dopamine 3 99.36 Very High Very High Very High
Potency 4 98.12 Very High Very High Very High
medulla 1 96.28 Very High Very High Very High
analgesia 1 92.44 High High
opioid receptor 2 90.88 High High
Endogenous opioid 3 89.84 High High
Disease Link Frequency Relevance Heat
Pain 3 98.32 Very High Very High Very High
Muscle Weakness 1 98.28 Very High Very High Very High
Cancer 2 97.92 Very High Very High Very High
Arthralgia 1 71.80 Quite High
Addisons Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Changes of type IV collagen 7S and fibronectine in a patient with isolated ACTH deficiency].
Regulation (isolated) of Negative_regulation (deficiency) of ACTH
1) Confidence 0.44 Published 1995 Journal Rinsho Shinkeigaku Section Title Doc Link 8521645 Disease Relevance 0.27 Pain Relevance 0.14
The voltage-sensitive Na+ channel blocker tetrodotoxin was used to investigate the role of Na+-dependent action potentials in beta-endorphin inhibition of K+-evoked norepinephrine release.
Spec (investigate) Regulation (role) of Negative_regulation (inhibition) of beta-endorphin associated with action potential and tetrodotoxin
2) Confidence 0.39 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9288827 Disease Relevance 0 Pain Relevance 0.53
[Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer (author's transl)].
Regulation ([Effects) of Negative_regulation (levels) of beta-endorphin in plasma associated with pain, dopamine and cancer
3) Confidence 0.33 Published 1981 Journal Sem Hop Section Title Doc Link 6269192 Disease Relevance 0.36 Pain Relevance 0.69
Bacitracin, phosphoramidon, thiorphan and captopril did not influence the twitch inhibition of met-enkephalin, but bestatin increased the twitch inhibitory potency of met-enkephalin and terminated it in a manner which almost paralleled that of untreated tissue.
Neg (not) Regulation (influence) of Negative_regulation (inhibition) of met-enkephalin associated with enkephalin and potency
4) Confidence 0.10 Published 1994 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8148819 Disease Relevance 0 Pain Relevance 0.64

General Comments

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