INT42504

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Context Info
Confidence 0.43
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.55
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Nox1) signal transduction (Nox1) transport (Nox1)
oxidoreductase activity (Nox1) plasma membrane (Nox1) extracellular matrix organization (Nox1)
Anatomy Link Frequency
liver 1
heart 1
Nox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 4 99.28 Very High Very High Very High
qutenza 1 98.08 Very High Very High Very High
Sciatic nerve 2 97.00 Very High Very High Very High
Calcium channel 3 88.00 High High
local anesthetic 4 79.52 Quite High
Paracetamol 2 67.44 Quite High
Bile 1 67.04 Quite High
Potency 3 64.08 Quite High
Angina 1 60.20 Quite High
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fungal Infection 13 92.32 High High
Hepatotoxicity 14 72.44 Quite High
Carbon Tetrachloride Poisoning 1 69.48 Quite High
Necrosis 1 67.84 Quite High
Hyperplasia 1 66.24 Quite High
Cirrhosis 1 64.88 Quite High
Cv General 3 Under Development 1 60.20 Quite High
Hypertension 1 59.88 Quite High
Toxicity 5 12.88 Low Low
Body Weight 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation with NOX-1 and verapamil did not significantly alter the dose-response curve of phenylephrine or calcium compared to verapamil treatment alone indicating L-type Ca2+ channel blockage leads to loss of NOX-1 activity.
Negative_regulation (loss) of NOX-1
1) Confidence 0.43 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19643099 Disease Relevance 0.12 Pain Relevance 0.18
In particular, the NADH-oxidase activity can be significantly inhibited by structural analogues of ubiquinone, such as capsaicin and resiniferatoxin.
Negative_regulation (inhibited) of NADH-oxidase associated with qutenza
2) Confidence 0.25 Published 1996 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 8953385 Disease Relevance 0 Pain Relevance 0.10
We report the following: (1) All of the anesthetics were found to inhibit each of the segments of the electron transport chain assayed; these included cytochrome c oxidase, durohydroquinone oxidase, succinate oxidase, NADH oxidase, succinate dehydrogenase, succinate-cytochrome c oxidoreductase, and NADH-cytochrome c oxidoreductase. (2) NADH oxidase and NADH-cytochrome c oxidoreductase required the lowest concentration of anesthetic for inhibition, and cytochrome c oxidase required the highest concentrations. (3) We conclude that there are several points along the chain at which inhibition occurs, the most sensitive being in the region of Complex I (NADH dehydrogenase). (4) Beef heart submitochondrial particles are less sensitive to inhibition than are rat liver particles. (5) Low concentrations of several of the anesthetics gave enhancement of electron transport activity, whereas higher concentrations of the same agents caused inhibition. (6) The concentrations of anesthetics (alcohol and tertiary amine) which gave 50% inhibition of NADH oxidase were lower than the reported concentrations required for blockage of frog sciatic nerve.
Negative_regulation (included) of NADH oxidase in heart associated with sciatic nerve and alcohol
3) Confidence 0.18 Published 1981 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6269599 Disease Relevance 0 Pain Relevance 0.27
We report the following: (1) All of the anesthetics were found to inhibit each of the segments of the electron transport chain assayed; these included cytochrome c oxidase, durohydroquinone oxidase, succinate oxidase, NADH oxidase, succinate dehydrogenase, succinate-cytochrome c oxidoreductase, and NADH-cytochrome c oxidoreductase. (2) NADH oxidase and NADH-cytochrome c oxidoreductase required the lowest concentration of anesthetic for inhibition, and cytochrome c oxidase required the highest concentrations. (3) We conclude that there are several points along the chain at which inhibition occurs, the most sensitive being in the region of Complex I (NADH dehydrogenase). (4) Beef heart submitochondrial particles are less sensitive to inhibition than are rat liver particles. (5) Low concentrations of several of the anesthetics gave enhancement of electron transport activity, whereas higher concentrations of the same agents caused inhibition. (6) The concentrations of anesthetics (alcohol and tertiary amine) which gave 50% inhibition of NADH oxidase were lower than the reported concentrations required for blockage of frog sciatic nerve.
Negative_regulation (inhibition) of NADH oxidase in liver associated with sciatic nerve and alcohol
4) Confidence 0.18 Published 1981 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6269599 Disease Relevance 0 Pain Relevance 0.20
Imidazoles potently inhibit NADH oxidase and succinate dehydrogenase.
Negative_regulation (inhibit) of NADH oxidase
5) Confidence 0.01 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809023 Disease Relevance 0.43 Pain Relevance 0.16

General Comments

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