INT42523

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Context Info
Confidence 0.16
First Reported 1981
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 1.03
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
kidney 3
filaments 1
gut 1
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 16 98.78 Very High Very High Very High
aspirin 9 98.48 Very High Very High Very High
cINOD 4 98.16 Very High Very High Very High
Buprenorphine 10 94.44 High High
Enkephalin 12 88.28 High High
Hippocampus 2 86.24 High High
Substantia nigra 2 81.52 Quite High
bradykinin 4 80.24 Quite High
cytokine 4 72.56 Quite High
agonist 1 71.36 Quite High
Disease Link Frequency Relevance Heat
Toxicity 34 99.44 Very High Very High Very High
Disease 2 92.96 High High
Breast Cancer 3 92.72 High High
Injury 2 88.92 High High
Cancer 3 75.12 Quite High
Apoptosis 1 74.36 Quite High
INFLAMMATION 3 69.60 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 66.88 Quite High
Arrhythmia Under Development 6 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemically, CE was demonstrated in the choroid plexus, where the enzyme appears to be bound, as in kidney and gut, to the surface of the epithelial cell bathed by luminal fluid.
enzyme Binding (bound) of in kidney
1) Confidence 0.16 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6289625 Disease Relevance 0 Pain Relevance 0.33
Rapid scan and transient state kinetic results on the reaction of compound II and acetaminophen show that: (i) compound II does not pass through any other intermediate when acetaminophen reduces it back to native enzyme; and (ii) a simple binding interaction before enzyme reduction is involved.
enzyme Binding (interaction) of associated with paracetamol
2) Confidence 0.06 Published 1993 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 8396889 Disease Relevance 0 Pain Relevance 0.92
Immunocytochemically, CE was demonstrated in the choroid plexus, where the enzyme appears to be bound, as in kidney and gut, to the surface of the epithelial cell bathed by luminal fluid.
enzyme Binding (bound) of in gut
3) Confidence 0.05 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6289625 Disease Relevance 0 Pain Relevance 0.33
The inhibitory effects of ASA and SA on PFK are fully reversible and can be prevented or reverted by the binding of the enzyme to the actin filaments.
enzyme Binding (binding) of in filaments associated with aspirin
4) Confidence 0.03 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 18851958 Disease Relevance 0.45 Pain Relevance 0.39
Compounds with selective affinity to the enzyme aromatase (CYP 19), namely 4-hydroxyandrostenedione and aminoglutethimide, caused >70% inhibition of norBUP formation.
enzyme Binding (affinity) of
5) Confidence 0.02 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12808001 Disease Relevance 0 Pain Relevance 0.79
This analysis shows the quantitative importance of the different kinetic parameters upon the overall binding affinity of these NSAIDs and should greatly assist in our understanding of the structural interactions that promote enzyme-inhibitor binding.
enzyme-inhibitor Binding (binding) of associated with cinod
6) Confidence 0.02 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8631960 Disease Relevance 0 Pain Relevance 0.19
Antibodies elicited against lung or kidney enzyme cross-reacted with enzyme from other organ, but not with the hog enzyme.
enzyme Binding (cross-reacted) of in kidney
7) Confidence 0.02 Published 1981 Journal Peptides Section Abstract Doc Link 6270633 Disease Relevance 0 Pain Relevance 0.22
Antibodies elicited against lung or kidney enzyme cross-reacted with enzyme from other organ, but not with the hog enzyme.
enzyme Binding (cross) of in kidney
8) Confidence 0.02 Published 1981 Journal Peptides Section Abstract Doc Link 6270633 Disease Relevance 0 Pain Relevance 0.21
The inhibition or induction of CYP3A4 by drugs often causes unfavorable and long-lasting drug-drug interactions and probably fatal toxicity, depending on many factors associated with the enzyme, drugs and the patients.
enzyme Binding (associated) of associated with toxicity
9) Confidence 0.01 Published 2008 Journal Curr. Drug Metab. Section Abstract Doc Link 18473749 Disease Relevance 0.22 Pain Relevance 0.14
The clinical outcomes due to CYP3A4 inactivation depend on many factors associated with the enzyme, drugs, and patients.
enzyme Binding (associated) of
10) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661603 Disease Relevance 0.26 Pain Relevance 0.11
The clinical outcomes due to CYP3A4 inactivation depend on many factors associated with the enzyme, drugs, and patients.
enzyme Binding (associated) of
11) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC1661603 Disease Relevance 0.10 Pain Relevance 0

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