INT42556

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Context Info
Confidence 0.44
First Reported 1981
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.11
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ace2) extracellular space (Ace2) extracellular region (Ace2)
plasma membrane (Ace2)
Anatomy Link Frequency
myocytes 1
cardiac myocytes 1
Ace2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 7 99.26 Very High Very High Very High
imagery 12 58.28 Quite High
antagonist 12 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertension 451 98.88 Very High Very High Very High
Sprains And Strains 24 90.64 High High
Cv Unclassified Under Development 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Method for measuring the duration of inhibition of angiotensin I-converting enzyme in vivo.
Negative_regulation (inhibition) of angiotensin I-converting enzyme associated with anesthesia
1) Confidence 0.44 Published 1981 Journal J Pharmacol Methods Section Title Doc Link 6273658 Disease Relevance 0.10 Pain Relevance 0.10
Medium was collected after exposing the WKY and SHR cells for 60 min at 37°C under two different enzyme inhibitors conditions (+All RAS inhibitors versus minus ACE/NEP/ACE2/chymase inhibitor only) and were analyzed by HPLC as described above.
Negative_regulation (inhibitor) of ACE2 associated with hypertension
2) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.10 Pain Relevance 0
Table 1 summarizes the effects of selective inhibition of ACE, NEP, ACE2, and chymase on 125I-Ang-(1–12) metabolism in the culture medium from both WKY and SHR.
Negative_regulation (inhibition) of ACE2 associated with hypertension
3) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.64 Pain Relevance 0
MLN-4760 (ACE2 inhibitor) was obtained from Millennium Pharmaceuticals (Cambridge, MA).
Negative_regulation (inhibitor) of ACE2
4) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.06 Pain Relevance 0.06
Although, the absence of the ACE2 inhibitor did not change the 125I-Ang-(1–12) level in the medium of the SHR myocytes, removal of the chymostatin inhibitor increased production of Ang I (20%) and Ang II (21%). 125I-Ang-(1–12) metabolism by SHR myocytes was significantly increased in the absence of chymostatin.
Negative_regulation (inhibitor) of ACE2 in myocytes associated with hypertension
5) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.73 Pain Relevance 0
Ang-(1–12) metabolism by cardiac myocytes was significantly blocked in the presence of specific enzyme inhibitors for ACE, neprilysin, ACE2, and chymase.
Negative_regulation (inhibitors) of ACE2 in cardiac myocytes
6) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.40 Pain Relevance 0
The contribution of ACE, NEP, ACE2 or chymase to the hydrolysis of 125I-Ang-(1–12) substrate were analyzed by measuring the amount of Ang products formation in the cultured medium after exposing the cells in the presence of all RAS inhibitors cocktail and in the absence of specific enzyme inhibitors for ACE, NEP, ACE2 or chymase only (as described above).
Negative_regulation (inhibitors) of ACE2
7) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3018413 Disease Relevance 0.09 Pain Relevance 0

General Comments

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