INT42581

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Context Info
Confidence 0.38
First Reported 1982
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 11
Total Number 15
Disease Relevance 9.25
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
chondrocytes 4
neutrophil 4
coronary artery 2
liver 2
leukocyte 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 171 100.00 Very High Very High Very High
anesthesia 3 100.00 Very High Very High Very High
Enkephalin 15 99.82 Very High Very High Very High
Osteoarthritis 132 99.64 Very High Very High Very High
COX-2 inhibitor 6 97.24 Very High Very High Very High
Arthritis 9 94.44 High High
Inflammatory response 30 92.68 High High
cytokine 54 89.64 High High
analgesia 1 88.60 High High
cINOD 10 85.60 High High
Disease Link Frequency Relevance Heat
Stress 238 100.00 Very High Very High Very High
INFLAMMATION 202 100.00 Very High Very High Very High
Lymphatic System Cancer 18 100.00 Very High Very High Very High
Osteoarthritis 144 99.64 Very High Very High Very High
Sepsis 6 99.60 Very High Very High Very High
Neutrophil Disorders 44 98.48 Very High Very High Very High
Liver Disease 86 98.20 Very High Very High Very High
Injury 102 97.60 Very High Very High Very High
Arthritis 12 96.48 Very High Very High Very High
Cancer 31 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Regulation (Effect) of Gene_expression (levels) of elastase associated with stress and sepsis
1) Confidence 0.38 Published 2005 Journal Clin. Chem. Lab. Med. Section Title Doc Link 15843228 Disease Relevance 1.05 Pain Relevance 0.13
M, indicating that human neutrophil elastase production is not affected by sulphasalazine at subtoxic levels.


Neg (not) Regulation (affected) of Gene_expression (production) of elastase in neutrophil
2) Confidence 0.23 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.59 Pain Relevance 0
Protein expression of human neutrophil elastase in lymphoma U937 cells was not affected by treatment with concentrations equivalent to therapeutic doses.
Neg (not) Regulation (affected) of Gene_expression (expression) of elastase in neutrophil associated with lymphatic system cancer
3) Confidence 0.23 Published 2004 Journal BMC Blood Disord Section Abstract Doc Link PMC535939 Disease Relevance 1.08 Pain Relevance 0.03
These data are consistent with the regulation of mPGES-1 expression by HNE at the transcription level.
Regulation (regulation) of Gene_expression (expression) of HNE
4) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.22 Pain Relevance 0.18
In our study, we also demonstrated that lower PGE2 production favors the 5-LOX pathway and LTB4 synthesis in HNE-treated OA chondrocytes.
Regulation (favors) of Gene_expression (synthesis) of HNE in chondrocytes associated with osteoarthritis
5) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 1.01 Pain Relevance 0.80
The objectives of the present project were to investigate whether COX-2 and mPGES-1 downregulation, attributed to HNE depletion, is responsible for the switch from COX-2 and mPGES-1 to 5-LOX and FLAP, and to elucidate the molecular mechanisms underlying their expression in HNE-treated human OA chondrocytes.


Regulation (underlying) of Gene_expression (expression) of HNE in chondrocytes associated with osteoarthritis
6) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.76 Pain Relevance 0.40
After HNE treatment, pRb remains
Regulation (After) of Gene_expression (treatment) of HNE
7) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.09 Pain Relevance 0
showed that the HNE effects depend on the inhibition of the cyclin expression,
Regulation (depend) of Gene_expression (effects) of HNE
8) Confidence 0.07 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.14 Pain Relevance 0
Data on acute liver injury should imply that during CLDs tissue levels of ROS and other mediators are likely to be lower; this has been shown for HNE levels, which ranged from 1–3 ?
Regulation (ranged) of Gene_expression (levels) of HNE in liver associated with liver disease and injury
9) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.99 Pain Relevance 0.15
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Regulation (resulted) of Gene_expression (synthesis) of HNE associated with stress
10) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.59 Pain Relevance 0.15
Therefore, the present study investigated the influence of different hyperoncotic and hypertonic-hyperoncotic solutions on polymorphonuclear neutrophil leukocyte (PMNL) count, elastase and superoxide-anion production in patients undergoing elective coronary artery bypass grafting (CABG) with cardiopulmonary bypass.
Spec (investigated) Regulation (influence) of Gene_expression (production) of elastase in leukocyte
11) Confidence 0.05 Published 2007 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 17578462 Disease Relevance 0.09 Pain Relevance 0.05
Effects of hyperoncotic or hypertonic-hyperoncotic solutions on polymorphonuclear neutrophil count, elastase- and superoxide-anion production: a randomized controlled clinical trial in patients undergoing elective coronary artery bypass grafting.
Regulation (Effects) of Gene_expression (production) of elastase in coronary artery associated with anesthesia
12) Confidence 0.05 Published 2007 Journal Acta Anaesthesiol Scand Section Title Doc Link 17578462 Disease Relevance 0.09 Pain Relevance 0.15
Bacitracin at 1 gm/L inhibited the degradation and oxidation of met5-enkephalin without affecting the production of superoxide and viability of PMN.
Neg (without) Regulation (affecting) of Gene_expression (production) of PMN associated with enkephalin
13) Confidence 0.03 Published 1982 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6276480 Disease Relevance 0.39 Pain Relevance 1.11
The effect of dihydrocucurbitacin B on the synthesis, release, and activity of pro-inflammatory enzymes (elastase, cyclooxygenase-2, and nitric oxide synthase-2) as well as its effect on different mediators (tumor necrosis factor-alpha and interleukin-1beta) were determined.
Spec (determined) Regulation (effect) of Gene_expression (synthesis) of elastase associated with necrosis, inflammation and cancer
14) Confidence 0.01 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16443215 Disease Relevance 0.96 Pain Relevance 0.23
PAO-R1, which carries a deletion in a regulatory gene that controls the production of elastase and alkaline protease, caused the same degree of lung and pleural injury as PAO-1 did.
Regulation (controls) of Gene_expression (production) of elastase in lung associated with injury
15) Confidence 0.00 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8282618 Disease Relevance 1.19 Pain Relevance 0

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