INT42583

Context Info Confidence 0.89 First Reported 1982 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 4.33 Pain Relevance 2.11

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)

Anatomy Link Frequency neutrophils 2 granulocyte 1 chondrocytes 1 Blood 1 connective tissue 1 ELANE (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 15 99.60 Osteoarthritis 105 99.48 anesthesia 3 97.88 Analgesic 5 96.76 Inflammation 95 96.48 cytokine 22 91.60 agonist 2 90.28 Morphine 1 89.96 Arthritis 14 79.04 metalloproteinase 23 78.72

Disease Link Frequency Relevance Heat Osteoarthritis 55 99.48 Cancer 20 99.24 INFLAMMATION 100 96.48 Hemarthrosis 4 94.40 Apoptosis 30 93.00 Sepsis 14 91.92 Adenomatous Polyps 8 90.68 Necrosis 6 90.44 Skin Cancer 3 86.48 Hyperplasia 1 83.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have examined the in vivo anti-inflammatory and analgesic activity of a new series of monocyclic beta-lactams (azetidinones), similar to others which have been demonstrated to be inhibitors of human leukocyte elastase (HLE), an enzyme involved in degradation processes of connective tissue.

Protein_catabolism (degradation) of HLE in connective tissue associated with inflammation and analgesic

1) Confidence 0.89 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10823683 Disease Relevance 0.25 Pain Relevance 0.32

We recently reported, for the first time, that free HNE induces cartilage degradation in isolated OA chondrocytes and alters the cellular phenotype of OA osteoblasts.

Protein_catabolism (degradation) of HNE in chondrocytes associated with osteoarthritis

2) Confidence 0.24 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.42

Blood was drawn for estimation of C3, C4, C3 degradation product, membrane attack complex, and CH100 levels and elastase (a marker of neutrophil activation) at induction of anesthesia, 5 minutes before reperfusion, 5 minutes and 60 minutes after reperfusion.

Protein_catabolism (degradation) of elastase in Blood associated with anesthesia

3) Confidence 0.18 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.14

PMN also degraded met5-(O)-enkephalin but to a lesser extent.

Protein_catabolism (degraded) of PMN associated with enkephalin

4) Confidence 0.08 Published 1982 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6276480 Disease Relevance 0.31 Pain Relevance 1.00

Moreover, human neutrophil elastase degrades F XIII and can encourage hemostatic disturbances and organ dysfunction [23].

Protein_catabolism (degrades) of neutrophil elastase in neutrophil

5) Confidence 0.06 Published 2006 Journal Crit Care Section Body Doc Link PMC1550842 Disease Relevance 1.06 Pain Relevance 0.04

Nevertheless, the 2/3 sulfate spatial pattern, which is common to all these sulfated polysaccharides, has been used to rationalise their cross-reactivity with certain monoclonal antibodies [18], their inhibitory activity against granulocyte elastase and insulin-like growth factor binding protein (IGFBP)-5 proteolysis and certain serine proteases of the complement, haemostatic and fibrinogenic systems [18,19,44,45].

Protein_catabolism (proteolysis) of granulocyte elastase in granulocyte

6) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0.03

Neutrophil elastase, secreted by neutrophils, is a main constituent of phagocytic response, degrading proteins within the local environment such as elastin, collagen and other constituents of extracellular matrix [43].

Protein_catabolism (degrading) of elastase in neutrophils

7) Confidence 0.02 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.03 Pain Relevance 0.04

Extracellularly released elastase is a potent lysosomal enzyme that degrades proteoglycans.

Protein_catabolism (degrades) of elastase

8) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 1.04 Pain Relevance 0.11

General Comments

This test has worked.