INT42583
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
We have examined the in vivo anti-inflammatory and analgesic activity of a new series of monocyclic beta-lactams (azetidinones), similar to others which have been demonstrated to be inhibitors of human leukocyte elastase (HLE), an enzyme involved in degradation processes of connective tissue. | |||||||||||||||
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We recently reported, for the first time, that free HNE induces cartilage degradation in isolated OA chondrocytes and alters the cellular phenotype of OA osteoblasts. | |||||||||||||||
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Blood was drawn for estimation of C3, C4, C3 degradation product, membrane attack complex, and CH100 levels and elastase (a marker of neutrophil activation) at induction of anesthesia, 5 minutes before reperfusion, 5 minutes and 60 minutes after reperfusion. | |||||||||||||||
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PMN also degraded met5-(O)-enkephalin but to a lesser extent. | |||||||||||||||
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Moreover, human neutrophil elastase degrades F XIII and can encourage hemostatic disturbances and organ dysfunction [23]. | |||||||||||||||
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Nevertheless, the 2/3 sulfate spatial pattern, which is common to all these sulfated polysaccharides, has been used to rationalise their cross-reactivity with certain monoclonal antibodies [18], their inhibitory activity against granulocyte elastase and insulin-like growth factor binding protein (IGFBP)-5 proteolysis and certain serine proteases of the complement, haemostatic and fibrinogenic systems [18,19,44,45]. | |||||||||||||||
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Neutrophil elastase, secreted by neutrophils, is a main constituent of phagocytic response, degrading proteins within the local environment such as elastin, collagen and other constituents of extracellular matrix [43]. | |||||||||||||||
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Extracellularly released elastase is a potent lysosomal enzyme that degrades proteoglycans. | |||||||||||||||
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