INT42585

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Context Info
Confidence 0.19
First Reported 1982
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Anatomy Link Frequency
retina 2
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 14 99.58 Very High Very High Very High
Enkephalin 4 89.36 High High
Immobilon 2 87.64 High High
methadone 2 87.20 High High
Morphine 2 86.76 High High
narcan 2 84.16 Quite High
agonist 2 81.76 Quite High
Clonidine 2 73.68 Quite High
Glutamate receptor 14 50.00 Quite Low
nMDA receptor 54 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Diphtheria 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoprecipitation of GluR1 was performed after the back phosphorylation of retinal SPM proteins (described above) using an immunoprecipitation kit (Protein G; Boehringer Mannheim, Indianapolis, IN).
Positive_regulation (performed) of Phosphorylation (phosphorylation) of SPM
1) Confidence 0.19 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
To determine if GluR1 phosphorylation by CaMKII in vivo is altered in the rdta retina, the SPM proteins of the rdta retina and their littermate controls are back phosphorylated by endogenous CaMKII in the presence of Ca2+/CaM (1 mM CaCl2 and 0.02 mg/ml calmodulin).
Positive_regulation (presence) of Phosphorylation (phosphorylated) of SPM in retina
2) Confidence 0.19 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
At 1 to 5 min after opioid administration, the phosphorylation of several SPM proteins is enhanced, followed at 10 to 20 min by a severe reduction in the rate of phosphorylation of the same proteins.
Positive_regulation (enhanced) of Phosphorylation (phosphorylation) of SPM associated with opioid
3) Confidence 0.11 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 0.91
Neither modulators, added separately or together to the assay, was able to restore a depressed phosphorylation to normal levels, although each modulator was effective in stimulating the phosphorylation of many SPM proteins.
Positive_regulation (stimulating) of Phosphorylation (phosphorylation) of SPM
4) Confidence 0.11 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6276532 Disease Relevance 0 Pain Relevance 0.67

General Comments

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