INT4259

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 11
Speculated 3
Reported most in Abstract
Documents 262
Total Number 265
Disease Relevance 49.37
Pain Relevance 123.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
pituitary 16
brain 10
olfactory bulb 7
smooth muscle cells 6
spinal cord 5
Npr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 244 100.00 Very High Very High Very High
Morphine 213 100.00 Very High Very High Very High
Dopamine 153 100.00 Very High Very High Very High
Opioid 125 100.00 Very High Very High Very High
Spinal cord 120 100.00 Very High Very High Very High
adenocard 99 100.00 Very High Very High Very High
opiate 97 100.00 Very High Very High Very High
Neurotransmitter 37 100.00 Very High Very High Very High
Kinase C 36 100.00 Very High Very High Very High
dorsal root ganglion 16 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 46 100.00 Very High Very High Very High
Natriuresis 43 100.00 Very High Very High Very High
Obesity 26 100.00 Very High Very High Very High
Ganglion Cysts 23 100.00 Very High Very High Very High
Vibrio Infection 98 99.98 Very High Very High Very High
Pain 73 99.82 Very High Very High Very High
INFLAMMATION 62 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 191 99.64 Very High Very High Very High
Hyperalgesia 109 99.22 Very High Very High Very High
Inflammatory Pain 13 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nitrite-elicited relaxation depends on activation of guanylate cyclase and high conductance Ca2+-activated potassium channels; however, activation of potassium channels might be a part of or might act in parallel with the mechanism involving the cyclic GMP system.
Positive_regulation (activation) of guanylate cyclase associated with potassium channel
1) Confidence 0.70 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10100881 Disease Relevance 0 Pain Relevance 0.16
Effects of nitrite observed in the presence of L-cysteine suggest that nitrosothiols are not responsible for nitrite-evoked activation of guanylate cyclase.
Positive_regulation (activation) of guanylate cyclase
2) Confidence 0.70 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10100881 Disease Relevance 0 Pain Relevance 0.09
The bladder and urethral activities during the rhythmic bladder contractions were evaluated before and after the intraarterial administration of methylene blue, which prevents the activation of soluble guanylate cyclase.
Positive_regulation (activation) of guanylate cyclase in bladder
3) Confidence 0.70 Published 1992 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 1306609 Disease Relevance 0 Pain Relevance 0
Thus, BNP negatively regulates nociceptive transmission through presynaptic receptor NPR-A, and activation of the BNP/NPR-A/PKG/BKCa channel pathway in nociceptive afferent neurons could be a potential strategy for inflammatory pain therapy.
Positive_regulation (activation) of NPR-A in afferent neurons associated with nociception and ipn
4) Confidence 0.67 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20702721 Disease Relevance 0.93 Pain Relevance 0.67
NO stimulates the enzyme guanylate cyclase, which results in increases in cyclic guanosine monophosphate and vasodilation.
Positive_regulation (stimulates) of guanylate cyclase associated with increased venous pressure under development
5) Confidence 0.66 Published 1996 Journal Am. J. Cardiol. Section Abstract Doc Link 8638524 Disease Relevance 0.62 Pain Relevance 0.05
A plausible hypothesis of the mechanism of nitrate-induced vasodilation has been presented, involving production of nitrosothiols and activation of guanylate cyclase in the vascular smooth muscle.
Positive_regulation (activation) of guanylate cyclase in smooth muscle associated with increased venous pressure under development
6) Confidence 0.66 Published 1985 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 3923783 Disease Relevance 0.53 Pain Relevance 0.29
Nitro-vasodilator drugs like nitroglycerin are metabolised in the cell given rise to short lived intermediates, which liberating nitric oxide that activate the guanylate cyclase enzyme, increasing the GMPc in smooth muscle cell.
Positive_regulation (activate) of guanylate cyclase in smooth muscle cell
7) Confidence 0.66 Published 1993 Journal Rev Esp Cardiol Section Abstract Doc Link 8430233 Disease Relevance 0.35 Pain Relevance 0.50
It is likely that the endothelium exerts part of its inhibitory influence through the activation of guanylate cyclase.
Positive_regulation (activation) of guanylate cyclase in endothelium
8) Confidence 0.66 Published 1989 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 2576779 Disease Relevance 0 Pain Relevance 0.09
The mechanism of the relaxant effect of the new compound consisted in the liberation of nitric-oxide (NO) which activated guanylate cyclase (GC), upon which accumulation of cyclic guanosine monophosphate (cGMP) occurred, which was the second messenger leading to relaxation.
Positive_regulation (activated) of guanylate cyclase
9) Confidence 0.66 Published 2004 Journal Arzneimittelforschung Section Abstract Doc Link 15146931 Disease Relevance 0 Pain Relevance 0.15
The compounds relax all smooth muscle cells by stimulating the soluble guanylate cyclase.
Positive_regulation (stimulating) of guanylate cyclase in smooth muscle cells
10) Confidence 0.65 Published 1996 Journal Herz Section Abstract Doc Link 8767922 Disease Relevance 0.47 Pain Relevance 0.19
NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries.
Positive_regulation (activates) of cyclase
11) Confidence 0.61 Published 2003 Journal Hypertension Section Title Doc Link 12743008 Disease Relevance 0 Pain Relevance 0
The local anesthetics appear to exert their inhibitory effect on endothelium-dependent vasodilation at a site distal to receptor activation at the endothelial cell and proximal to guanylate cyclase activation in the vascular smooth muscle.
Positive_regulation (activation) of cyclase in endothelial cell associated with increased venous pressure under development and local anesthetic
12) Confidence 0.60 Published 1989 Journal Anesthesiology Section Abstract Doc Link 2719315 Disease Relevance 0.32 Pain Relevance 0.38
While the contraction in the opossum seems to be related to guanylate cyclase activation, this is not the case in the rat ileum, as methylene blue did not influence the contractions and 8-bromo-cGMP only had a relaxant effect.
Positive_regulation (activation) of cyclase in ileum
13) Confidence 0.60 Published 1995 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7639620 Disease Relevance 0 Pain Relevance 0.20
The data suggest that the opiate analogue interferes with the secretory process at a point beyond the cAMP increase caused by activation of adenylate cyclase.
Positive_regulation (activation) of cyclase associated with opiate
14) Confidence 0.59 Published 1981 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6272133 Disease Relevance 0 Pain Relevance 0.10
This action is independent of guanylate cyclase activation, and most likely shares a common mechanism with classic monoamine releasers such as amphetamine that cause direct release of NE from vesicles into the nerve terminal cytoplasm, leading to extracellular release by reverse transport.
Positive_regulation (activation) of cyclase in nerve associated with monoamine
15) Confidence 0.59 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10688602 Disease Relevance 0 Pain Relevance 0.31
Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy.
Positive_regulation (Increased) of natriuretic peptide receptor associated with natriuresis and coronary heart disease
16) Confidence 0.59 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 16272201 Disease Relevance 0.89 Pain Relevance 0.22
Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw.
Positive_regulation (up-regulation) of cyclase in paw associated with inflammation and spinal cord
17) Confidence 0.58 Published 2002 Journal Neuroscience Section Title Doc Link 12044461 Disease Relevance 0.38 Pain Relevance 0.70
Nitric oxide activates guanylate cyclase, resulting in an accumulation of cyclic GMP.
Positive_regulation (activates) of guanylate cyclase
18) Confidence 0.57 Published 1991 Journal Nurs. Clin. North Am. Section Abstract Doc Link 1904576 Disease Relevance 0.31 Pain Relevance 0.11
These results suggest that a sustained production of nitric oxide and subsequent activation of soluble guanylate cyclase in the lumbar spinal cord mediate the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Positive_regulation (activation) of cyclase in spinal cord associated with thermal hyperalgesia, neuropathic pain and spinal cord
19) Confidence 0.53 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.92 Pain Relevance 0.97
As the acute nociceptive effects of N-methyl-D-aspartate have been reported to be mediated through production of nitric oxide and activation of soluble guanylate cyclase, these experiments were designed to determine whether the thermal hyperalgesia produced in a rat model of neuropathic pain is also mediated through the production of nitric oxide and activation of soluble guanylate cyclase.
Positive_regulation (activation) of cyclase associated with nociception, thermal hyperalgesia and neuropathic pain
20) Confidence 0.53 Published 1992 Journal Neuroscience Section Abstract Doc Link 1407561 Disease Relevance 0.70 Pain Relevance 0.72

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox