INT4261

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.04
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
blood 2
brainstem 2
heart 2
median eminence 2
Urine 2
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 18 99.98 Very High Very High Very High
anesthesia 7 99.70 Very High Very High Very High
medulla 1 96.60 Very High Very High Very High
Clonidine 6 96.12 Very High Very High Very High
Pain 3 95.28 Very High Very High Very High
Ultiva 5 94.32 High High
Analgesic 1 92.32 High High
epidural 2 82.00 Quite High
analgesia 1 81.64 Quite High
Dismenorea 1 76.80 Quite High
Disease Link Frequency Relevance Heat
Stress 2 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 2 99.90 Very High Very High Very High
Volume Depletion And Dehydration 4 99.84 Very High Very High Very High
Pressure And Volume Under Development 2 99.52 Very High Very High Very High
Renal Failure 1 99.18 Very High Very High Very High
Increased Venous Pressure Under Development 1 98.96 Very High Very High Very High
Diuresis 3 97.72 Very High Very High Very High
Hyponatremia 2 96.40 Very High Very High Very High
Pain 3 95.28 Very High Very High Very High
Heart Rate Under Development 2 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenous isoproterenol lowered blood pressure and increased ADH release and heart rate.
Positive_regulation (increased) of Localization (release) of ADH in heart associated with pressure volume 2 under development
1) Confidence 0.61 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.19 Pain Relevance 0.23
Hence the histological changes induced by NaF administration in the HNS of the spotted owlet are presumably indicative of increased neurosecretory activity resulting in the augmented secretion of ADH.
Positive_regulation (augmented) of Localization (secretion) of ADH
2) Confidence 0.53 Published 1975 Journal Endocrinol. Exp. Section Abstract Doc Link 1079182 Disease Relevance 0 Pain Relevance 0.09
These results indicate that extradural morphine induces ADH secretion and suggest that this effect is the consequence of the migration of morphine to the brainstem.
Positive_regulation (induces) of Localization (secretion) of ADH in brainstem associated with medulla and morphine
3) Confidence 0.50 Published 1985 Journal Br J Anaesth Section Abstract Doc Link 3986069 Disease Relevance 0 Pain Relevance 0.66
This is caused mainly by fluid overload due to excesssive drinking and a release of ADH induced by hypovolemia and stress which impairs the excretion of free water.
Positive_regulation (induced) of Localization (release) of ADH
4) Confidence 0.46 Published 2007 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 17726655 Disease Relevance 0.05 Pain Relevance 0
Due to water retention and drinking following stimulation of ADH secretion and thirst, osmoregulation is overruled by volume conservatory mechanisms, which lead to hyponatremia.
Positive_regulation (stimulation) of Localization (secretion) of ADH associated with hyponatremia and pressure and volume under development
5) Confidence 0.46 Published 1993 Journal Schweiz. Rundsch. Med. Prax. Section Abstract Doc Link 8362127 Disease Relevance 0.78 Pain Relevance 0.06
The NSM in the hypothalamo-hypophysial tract, the zona externa of the anterior median eminence (ME) and in the neural lobe (NL) showed only a partial lossmthe effects of NaF administration on the HNS of the spotted owlet are similar to those induced by such stimulators of ADH secretion as hypertonic saline, morphine and formalin.
Positive_regulation (induced) of Localization (secretion) of ADH in median eminence associated with morphine
6) Confidence 0.38 Published 1975 Journal Endocrinol. Exp. Section Abstract Doc Link 1079182 Disease Relevance 0 Pain Relevance 0.10
The increased release of ADH after peripheral administration of isoproterenol was presumably due to the reduction in blood pressure and decreased baroreceptor inhibition of ADH release.
Positive_regulation (increased) of Localization (release) of ADH in blood
7) Confidence 0.36 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.16 Pain Relevance 0.22
BACKGROUND: Transient renal failure during surgery is caused by increasing secretion of stress hormone such as ADH and renin.
Positive_regulation (increasing) of Localization (secretion) of ADH associated with stress and renal failure
8) Confidence 0.27 Published 2010 Journal Masui Section Abstract Doc Link 20169953 Disease Relevance 0.20 Pain Relevance 0.58
By contrast, the surgical procedure may induce the secretion of ADH responsible for coronary vasoconstriction.
Spec (may) Positive_regulation (induce) of Localization (secretion) of ADH associated with increased venous pressure under development
9) Confidence 0.24 Published 1980 Journal Ann Anesthesiol Fr Section Abstract Doc Link 6109497 Disease Relevance 0.20 Pain Relevance 0.16
Urine concentration was assessed under conditions of: (1) stimulation of ADH release by dehydration or barbiturate anaesthesia; (2) mannitol diuresis, and (3) isotonic saline diuresis.
Positive_regulation (stimulation) of Localization (release) of ADH in Urine associated with diuresis and volume depletion and dehydration
10) Confidence 0.14 Published 1980 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 6788564 Disease Relevance 0.29 Pain Relevance 0
[Anesthesia procedure and postoperative ADH secretion].
Positive_regulation (postoperative) of Localization (secretion) of ADH associated with anesthesia
11) Confidence 0.09 Published 1983 Journal Anaesthesist Section Title Doc Link 6881520 Disease Relevance 0.17 Pain Relevance 0.66
The histological changes in the HNS induced by low doses of morphine are comparable to the changes induced by hypertonic saline administration and are presumably indicative of augmented secretion of the ADH.
Positive_regulation (augmented) of Localization (secretion) of ADH associated with morphine
12) Confidence 0.05 Published 1975 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 1217861 Disease Relevance 0 Pain Relevance 0.74

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