INT42632

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Context Info
Confidence 0.42
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.84
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
basement membrane 1
epi (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 5 99.96 Very High Very High Very High
antagonist 3 99.74 Very High Very High Very High
Pain 23 86.92 High High
Perioperative pain 11 86.72 High High
Clonidine 1 79.84 Quite High
agonist 2 77.44 Quite High
Catecholamine 2 76.00 Quite High
anesthesia 1 50.72 Quite High
GABAergic 1 27.28 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pain 33 86.92 High High
Post Operative Pain 12 86.72 High High
Nociception 2 84.28 Quite High
Convulsion 2 83.64 Quite High
Aggression 2 80.48 Quite High
Astigmatism 4 69.72 Quite High
Myopia 6 69.24 Quite High
Stress 1 29.60 Quite Low
Apoptosis 3 25.20 Quite Low
INFLAMMATION 4 14.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At a large dose (400 mg/kg, p.o.), PI-E not only decreased locomotor activity but also prolonged pentobarbital sleep in group-housed mice.
Negative_regulation (decreased) of PI-E associated with eae
1) Confidence 0.42 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8924905 Disease Relevance 0.30 Pain Relevance 0.22
In the same interval, plasma Epi rose by 292 +/- 30 pg/ml, of which 123 +/- 18 pg/ml (approximately 42%) was due to Epi total body spillover and 169 +/- 19 pg/ml to reduced Epi total body clearance.
Negative_regulation (reduced) of Epi in plasma
2) Confidence 0.28 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8779844 Disease Relevance 0 Pain Relevance 0.09
Yohimbine (YO), a specific alpha 2-antagonist, completely inhibited the Epi effect on Isc.
Negative_regulation (inhibited) of Epi associated with antagonist
3) Confidence 0.18 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 6278952 Disease Relevance 0 Pain Relevance 0.33
Tanioka et al. [8], however, reported that the basement membrane was partially or totally lost after epi-LASIK, and that most basal cells in the epithelial flaps appeared to be dead.
Negative_regulation (lost) of epi-LASIK in basement membrane
4) Confidence 0.02 Published 2010 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2882076 Disease Relevance 0.54 Pain Relevance 0.33

General Comments

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