INT42655

Context Info Confidence 0.59 First Reported 1982 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 1.13 Pain Relevance 0.80

small molecule metabolic process (LCT) plasma membrane (LCT) carbohydrate metabolic process (LCT)

Anatomy Link Frequency intestinal cells 1 internal 1 LCT (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 5 96.90 Opioid 5 95.68 antagonist 1 71.36 nud 2 71.24 opiate 1 70.92 abdominal pain 2 70.40 melanocortin 1 receptor 3 10.68

Disease Link Frequency Relevance Heat Obesity 82 99.08 Hypoglycemia 6 97.58 Malabsorption Syndromes 4 92.92 Diarrhoea 6 79.00 Dyspepsia 2 71.24 Abdominal Pain 2 70.40 Cancer 8 21.12 Nicotine Addiction 2 18.24 Metabolic Syndrome 6 5.00 Disease 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The T allele correlated perfectly with the LP phenotype of intestinal cells and functional studies have shown that the T allele is associated with the disrupted down-regulation of the LCT gene during childhood (2,3).

Regulation (regulation) of LCT in intestinal cells

1) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830824 Disease Relevance 0.38 Pain Relevance 0.11

Although explanation at a functional level is a matter for future studies and finding is not significant in the GWAS established genome-wide level of significance, we propose that the European variant behind LP, and perhaps other variants affecting the regulatory region of LCT, contributes to human obesity.

Regulation (affecting) of LCT associated with obesity

2) Confidence 0.51 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830824 Disease Relevance 0.33 Pain Relevance 0

To ensure that the copy number of nuclear DNA was sufficient for amplifying nuclear Neanderthal DNA and to monitor potential nuclear DNA contamination, we additionally amplified a control position on the lactase gene [LCT] promoter (MCM6 locus).

Regulation (control) of LCT

3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0

To ensure that the copy number of nuclear DNA was sufficient for amplifying nuclear Neanderthal DNA and to monitor potential nuclear DNA contamination, we additionally amplified a control position on the lactase gene [LCT] promoter (MCM6 locus).

Regulation (control) of lactase

4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0

Amplification of nuclear internal control (LCT promoter)

Regulation (control) of LCT in internal

5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0

The association of naloxone with insulin-induced hypoglycemia significantly reduced the PRL peak (p less than 0.05), did not affect the rise of GH and lowered the ACTH peak, without altering the LPH peak.

Neg (without) Regulation (altering) of LPH associated with hypoglycemia and narcan

6) Confidence 0.13 Published 1982 Journal Nouv Presse Med Section Abstract Doc Link 6280130 Disease Relevance 0.42 Pain Relevance 0.70

General Comments

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