INT42655

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Context Info
Confidence 0.59
First Reported 1982
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.13
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (LCT) plasma membrane (LCT) carbohydrate metabolic process (LCT)
Anatomy Link Frequency
intestinal cells 1
internal 1
LCT (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 5 96.90 Very High Very High Very High
Opioid 5 95.68 Very High Very High Very High
antagonist 1 71.36 Quite High
nud 2 71.24 Quite High
opiate 1 70.92 Quite High
abdominal pain 2 70.40 Quite High
melanocortin 1 receptor 3 10.68 Low Low
Disease Link Frequency Relevance Heat
Obesity 82 99.08 Very High Very High Very High
Hypoglycemia 6 97.58 Very High Very High Very High
Malabsorption Syndromes 4 92.92 High High
Diarrhoea 6 79.00 Quite High
Dyspepsia 2 71.24 Quite High
Abdominal Pain 2 70.40 Quite High
Cancer 8 21.12 Low Low
Nicotine Addiction 2 18.24 Low Low
Metabolic Syndrome 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The T allele correlated perfectly with the LP phenotype of intestinal cells and functional studies have shown that the T allele is associated with the disrupted down-regulation of the LCT gene during childhood (2,3).
Regulation (regulation) of LCT in intestinal cells
1) Confidence 0.59 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830824 Disease Relevance 0.38 Pain Relevance 0.11
Although explanation at a functional level is a matter for future studies and finding is not significant in the GWAS established genome-wide level of significance, we propose that the European variant behind LP, and perhaps other variants affecting the regulatory region of LCT, contributes to human obesity.


Regulation (affecting) of LCT associated with obesity
2) Confidence 0.51 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830824 Disease Relevance 0.33 Pain Relevance 0
To ensure that the copy number of nuclear DNA was sufficient for amplifying nuclear Neanderthal DNA and to monitor potential nuclear DNA contamination, we additionally amplified a control position on the lactase gene [LCT] promoter (MCM6 locus).
Regulation (control) of LCT
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
To ensure that the copy number of nuclear DNA was sufficient for amplifying nuclear Neanderthal DNA and to monitor potential nuclear DNA contamination, we additionally amplified a control position on the lactase gene [LCT] promoter (MCM6 locus).
Regulation (control) of lactase
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
Amplification of nuclear internal control (LCT promoter)
Regulation (control) of LCT in internal
5) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871044 Disease Relevance 0 Pain Relevance 0
The association of naloxone with insulin-induced hypoglycemia significantly reduced the PRL peak (p less than 0.05), did not affect the rise of GH and lowered the ACTH peak, without altering the LPH peak.
Neg (without) Regulation (altering) of LPH associated with hypoglycemia and narcan
6) Confidence 0.13 Published 1982 Journal Nouv Presse Med Section Abstract Doc Link 6280130 Disease Relevance 0.42 Pain Relevance 0.70

General Comments

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