INT4268

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Context Info
Confidence 0.34
First Reported 1975
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 14
Disease Relevance 9.70
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Phospho1)
Anatomy Link Frequency
bladder 4
urinary bladder 3
spinal 1
ankle 1
Phospho1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 32 100.00 Very High Very High Very High
long-term potentiation 16 98.80 Very High Very High Very High
Inflammation 34 95.60 Very High Very High Very High
intrathecal 2 89.04 High High
Neuritis 3 87.56 High High
Dorsal horn 1 87.16 High High
cva 8 86.72 High High
Sciatic nerve 1 82.92 Quite High
Multiple sclerosis 12 82.56 Quite High
Visceral pain 7 82.44 Quite High
Disease Link Frequency Relevance Heat
Cystitis 35 99.82 Very High Very High Very High
Arthritis 1 98.72 Very High Very High Very High
Arrhythmias 2 Under Development 1 96.84 Very High Very High Very High
Myocardial Infarction 1 95.72 Very High Very High Very High
INFLAMMATION 27 95.60 Very High Very High Very High
Overactive Bladder 22 95.44 Very High Very High Very High
Anaerobic Bacterial Infections 1 92.12 High High
Ganglion Cysts 3 92.04 High High
Shock 1 90.76 High High
Pressure Volume 2 Under Development 1 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cystitis-induced upregulation of phospho-ERK1/2 and phospho-ERK5 was time dependent and showed similar patterns in female and male rats.
Positive_regulation (upregulation) of phospho-ERK1 associated with cystitis
1) Confidence 0.34 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.80 Pain Relevance 0.46
The level of phospho-ERK1/2 in bladder was increased at 2 and 8 h after CYP injection; the level of phospho-ERK5 in DRG was increased at 8 and 48 h after CYP injection; and the level of phospho-ERK1/2 in lumbar spinal cord was increased at 48 h after CYP injection.
Positive_regulation (increased) of phospho-ERK1 in bladder associated with spinal cord
2) Confidence 0.23 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.75 Pain Relevance 0.46
The level of phospho-ERK1/2 but not phospho-ERK5 was increased in the urinary bladder; the level of phospho-ERK5 but not phospho-ERK1/2 was increased in DRG; and the level of phospho-ERK1/2 but not phospho-ERK5 was increased in lumbar spinal cord following cystitis compared with control.
Positive_regulation (increased) of phospho-ERK1 in urinary bladder associated with cystitis and spinal cord
3) Confidence 0.23 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.82 Pain Relevance 0.45
The level of phospho-ERK1/2 but not phospho-ERK5 was increased in the urinary bladder; the level of phospho-ERK5 but not phospho-ERK1/2 was increased in DRG; and the level of phospho-ERK1/2 but not phospho-ERK5 was increased in lumbar spinal cord following cystitis compared with control.
Positive_regulation (increased) of phospho-ERK1 in urinary bladder associated with cystitis and spinal cord
4) Confidence 0.23 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.84 Pain Relevance 0.45
The level of phospho-ERK1/2 in bladder was increased at 2 and 8 h after CYP injection; the level of phospho-ERK5 in DRG was increased at 8 and 48 h after CYP injection; and the level of phospho-ERK1/2 in lumbar spinal cord was increased at 48 h after CYP injection.
Positive_regulation (increased) of phospho-ERK1 in bladder associated with spinal cord
5) Confidence 0.23 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.70 Pain Relevance 0.44
The result that phospho-ERK5 was exclusively increased in DRG neurons, while phospho-ERK1/2 was increased in the spinal cord and the urinary bladder after cystitis, suggests a region-specific effect of neurotrophins on micturition pathways following bladder inflammation.
Positive_regulation (increased) of phospho-ERK1 in bladder associated with inflammation, overactive bladder, cystitis and spinal cord
6) Confidence 0.23 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.79 Pain Relevance 0.30
The level of phospho-ERK1/2 but not phospho-ERK5 was increased in the urinary bladder; the level of phospho-ERK5 but not phospho-ERK1/2 was increased in DRG; and the level of phospho-ERK1/2 but not phospho-ERK5 was increased in lumbar spinal cord following cystitis compared with control.
Positive_regulation (increased) of phospho-ERK1 in urinary bladder associated with cystitis and spinal cord
7) Confidence 0.23 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17110531 Disease Relevance 0.83 Pain Relevance 0.43
We identified three independent intracellular signaling pathways involved in Epo-induced neuroprotection in vivo: Protein levels of phospho-Akt, phospho-MAPK 1 and 2, and Bcl-2 were increased under Epo application.
Positive_regulation (increased) of phospho-Akt
8) Confidence 0.16 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15459752 Disease Relevance 0.64 Pain Relevance 0.24
We identified three independent intracellular signaling pathways involved in Epo-induced neuroprotection in vivo: Protein levels of phospho-Akt, phospho-MAPK 1 and 2, and Bcl-2 were increased under Epo application.
Positive_regulation (increased) of phospho-MAPK 1
9) Confidence 0.16 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15459752 Disease Relevance 0.64 Pain Relevance 0.24
Using a combined treatment of Epo together with a selective inhibitor of phosphatidylinositol 3-kinase (PI3-K) prevented upregulation of phospho-Akt and consecutive RGC rescue.
Positive_regulation (upregulation) of phospho-Akt
10) Confidence 0.15 Published 2004 Journal Cell Death Differ. Section Abstract Doc Link 15459752 Disease Relevance 0.59 Pain Relevance 0.22
Results indicated that, in non-inflamed rats, noxious but not innocuous bladder distension significantly increased spinal phosphoERK immunoreactivity from its normal very low level.
Positive_regulation (increased) of phosphoERK in bladder
11) Confidence 0.13 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15733095 Disease Relevance 0.22 Pain Relevance 0.28
PhosphoERK immunoreactivity was not induced by movement of ankles from non-arthritic control animals, neither in monoarthritic rats in which the inflamed ankle was not stimulated.
Neg (not) Positive_regulation (induced) of PhosphoERK in ankle associated with arthritis
12) Confidence 0.08 Published 2005 Journal Pain Section Abstract Doc Link 15979799 Disease Relevance 0.67 Pain Relevance 0.37
As far as biological tests are concerned, it should be noted that elevation of creatine phospho-kinase to levels 4 times greater than normal may be seen, creating problems with the differential diagnosis from myocardial infarction.
Positive_regulation (elevation) of phospho-kinase associated with myocardial infarction
13) Confidence 0.04 Published 1975 Journal Nouv Presse Med Section Abstract Doc Link 1082575 Disease Relevance 0.84 Pain Relevance 0.31
We found that (1) the protein level of phospho-CaMKII increased at both 30 min and 3 h after LTP induction, while the total protein level of CaMK II increased at 3 h but not at 30 min after LTP induction. (2) Spinal application of KN-93 at 30 min prior to the tetanus blocked both LTP induction and the increase in phospho-CaMK II. (3) 30 min after LTP induction, spinal application of KN-93 depressed LTP and the level of phospho-CaMK II (n=3). (4) Spinal application of KN-93 at 3 h after LTP, however, affected neither the amplitude of the spinal LTP nor the level of phospho-CaMK II in the spinal dorsal horn.
Positive_regulation (increased) of phospho-CaMKII in spinal associated with spinal dorsal horn, anaerobic bacterial infections and long-term potentiation
14) Confidence 0.04 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 14985835 Disease Relevance 0.09 Pain Relevance 0.91

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