INT4270

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Context Info
Confidence 0.43
First Reported 1975
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 1.08
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agt) aging (Agt) extracellular region (Agt)
extracellular matrix organization (Agt)
Anatomy Link Frequency
plasma 2
ICV 2
heart 2
Agt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 3 99.98 Very High Very High Very High
narcan 3 99.84 Very High Very High Very High
Opioid 5 99.28 Very High Very High Very High
antagonist 16 99.08 Very High Very High Very High
Intracerebroventricular 3 97.44 Very High Very High Very High
Serotonin 2 96.40 Very High Very High Very High
Angina 3 95.96 Very High Very High Very High
analgesia 1 95.72 Very High Very High Very High
tail-flick 1 89.84 High High
Calcitonin gene-related peptide 11 86.88 High High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 3 95.96 Very High Very High Very High
Increased Venous Pressure Under Development 4 92.76 High High
Arrhythmia Under Development 2 90.52 High High
Premature Ventricular Beats 1 77.52 Quite High
Pain 1 77.12 Quite High
Hypertension 40 75.00 Quite High
Arrhythmias 2 Under Development 1 65.64 Quite High
INFLAMMATION 2 25.00 Low Low
Diabetes Mellitus 11 14.24 Low Low
Renal Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tempol prevented an Ang II dependent decrease in medullary (but not cortical) NO without affecting RBF or IMBF responses.
Negative_regulation (prevented) of Negative_regulation (decrease) of Ang II
1) Confidence 0.43 Published 2004 Journal Acta Physiol. Scand. Section Body Doc Link 15491410 Disease Relevance 0 Pain Relevance 0
The inhibitory effects of RS, AngI and AngII were abolished by the AngII receptor antagonist, [Sar1,Ile8]AngII (500 nM).
Negative_regulation (abolished) of Negative_regulation (effects) of AngII associated with antagonist
2) Confidence 0.43 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9454791 Disease Relevance 0.41 Pain Relevance 0.55
The Ang II receptor antagonist saralasin 150 micrograms/kg ICV, blunted and 300 micrograms/kg ICV reversed the effect of Ang II.
Negative_regulation (reversed) of Negative_regulation (effect) of Ang II in ICV associated with antagonist
3) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1654493 Disease Relevance 0.32 Pain Relevance 0.64
Using EC33, a selective aminopeptidase A inhibitor which blocks the metabolism of Ang II in Ang III, we previously reported that vasopressin release was under the control of Ang III and not Ang II.
Negative_regulation (blocks) of Negative_regulation (metabolism) of Ang III
4) Confidence 0.42 Published 1998 Journal Neuroreport Section Abstract Doc Link 9579673 Disease Relevance 0 Pain Relevance 0.04
Using EC33, a selective aminopeptidase A inhibitor which blocks the metabolism of Ang II in Ang III, we previously reported that vasopressin release was under the control of Ang III and not Ang II.
Negative_regulation (blocks) of Negative_regulation (metabolism) of Ang II
5) Confidence 0.42 Published 1998 Journal Neuroreport Section Abstract Doc Link 9579673 Disease Relevance 0 Pain Relevance 0.04
As regards blood pressure and heart rate a similar behaviour was registered in the two groups in basal conditions; directly after the intravenous injection of Angiotensin II changes suggesting impairment of left ventricular function failure have been obsered in patients with angina pectoris.
Negative_regulation (registered) of Negative_regulation (injection) of Angiotensin II in heart associated with angina
6) Confidence 0.41 Published 1975 Journal Acta Cardiol Section Abstract Doc Link 1082699 Disease Relevance 0.27 Pain Relevance 0.27
Analgesic effects of the endogenous and exogenous Ang II are prevented by naloxone--1 mg/kg i.p.
Negative_regulation (prevented) of Negative_regulation (effects) of Ang II associated with analgesic and narcan
7) Confidence 0.36 Published 1983 Journal Physiologie Section Abstract Doc Link 6417696 Disease Relevance 0.08 Pain Relevance 0.81
This effect of angiotensin I, but not of angiotensin II, was abolished by captopril (1 mg/kg, i.v.), and the effect of angiotensin II was abolished by Sar1-Ala8-angiotensin II (0.5 micrograms/kg/min, i.v.).
Negative_regulation (abolished) of Negative_regulation (effect) of angiotensin
8) Confidence 0.26 Published 1981 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6160349 Disease Relevance 0 Pain Relevance 0.03
This effect of angiotensin I, but not of angiotensin II, was abolished by captopril (1 mg/kg, i.v.), and the effect of angiotensin II was abolished by Sar1-Ala8-angiotensin II (0.5 micrograms/kg/min, i.v.).
Negative_regulation (abolished) of Negative_regulation (effect) of angiotensin
9) Confidence 0.26 Published 1981 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 6160349 Disease Relevance 0 Pain Relevance 0.03
It also inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increases in plasma renin activity and angiotensin II circulating levels do not overcome the blockade exerted by telmisartan (Stangier et al 2001; de Gasparo 2004).
Negative_regulation (inhibits) of Negative_regulation (feedback) of angiotensin II in plasma
10) Confidence 0.23 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0

General Comments

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