INT42707

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Context Info
Confidence 0.65
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 12.92
Pain Relevance 7.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
leukocytes 3
macrophages 1
Granulocyte 1
blood 1
poly 1
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 288 100.00 Very High Very High Very High
lidocaine 620 99.82 Very High Very High Very High
agonist 51 98.92 Very High Very High Very High
idiopathic sensory neuropathy 1 98.84 Very High Very High Very High
Kinase C 20 98.76 Very High Very High Very High
cINOD 15 98.40 Very High Very High Very High
Inflammation 819 98.36 Very High Very High Very High
metalloproteinase 35 93.56 High High
Inflammatory response 94 90.04 High High
Spinal cord 285 89.84 High High
Disease Link Frequency Relevance Heat
Apoptosis 125 100.00 Very High Very High Very High
Neuropathic Pain 8 100.00 Very High Very High Very High
Urological Neuroanatomy 23 99.12 Very High Very High Very High
Endotoxemia 2 98.80 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 14 98.56 Very High Very High Very High
INFLAMMATION 891 98.36 Very High Very High Very High
Lifespan 5 97.52 Very High Very High Very High
Cancer 13 96.44 Very High Very High Very High
Thrombosis Related Under Development 3 94.88 High High
Injury 397 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated PMNs produce MIP-2 (mouse) or IL-8 (human), which produces an auto-amplification loop of PMN recruitment and activation at the inflamed sites, and this positive feedback is considered to be one of the potential mechanisms by which MIP-2 could amplify the local inflammatory response of the PMNs [23,24].
Gene_expression (produce) of PMN associated with inflammatory response
1) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.91 Pain Relevance 0.30
We focused on two specific groups: collagenases and gelatinases; evaluating the expression of interstitial collagenase (MMP-1) and PMN collagenase (MMP-8), both of which can be secreted by corneal cells and are able to cleave corneal stromal collagens.
Gene_expression (expression) of PMN
2) Confidence 0.58 Published 2003 Journal BMC Ophthalmol Section Body Doc Link PMC239861 Disease Relevance 0.34 Pain Relevance 0.17
Similar to lung cytokine measurements, there was an overall significant effect of both mechanical ventilation and genotype on BALF PMN count in poly(I:C)-treated mice (Figure 3A).
Gene_expression (count) of PMN in poly associated with cytokine
3) Confidence 0.10 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 0 Pain Relevance 0.12
In rabbits, mechanical ventilation during endotoxemia synergistically increases alveolar polymorphonuclear cell (PMN) recruitment and cytokine expression in BALF beyond that seen with either endotoxin or mechanical ventilation alone [7,8].
Gene_expression (expression) of PMN associated with endotoxemia and cytokine
4) Confidence 0.10 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 1.22 Pain Relevance 0.16
Such a mild hyper-reactivity was unlikely due to inherent alterations in white blood cell phenotype, as we did not detect different basal expression of PMN or monocyte markers in WT and MC3R-null circulating cells.
Gene_expression (expression) of PMN in white blood cell
5) Confidence 0.09 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.15 Pain Relevance 0.10
A previous study found that the expression of NEP on circulating PMN was reduced in humans challenged with LPS [40].
Gene_expression (expression) of PMN
6) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.03 Pain Relevance 0.15
Previous studies have observed the expression of NEP on the surface of PMN [38,39].
Gene_expression (expression) of PMN
7) Confidence 0.07 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.95 Pain Relevance 0.16
Galectin-1 inhibits PMN migration during PMN-endothelial interactions in vitro and in vivo [23].
Gene_expression (migration) of PMN
8) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.37 Pain Relevance 0.61
At 48 h after zymosan challenge, lidocaine at 0.08% also reduced PMN apoptosis ?
Gene_expression (apoptosis) of PMN associated with apoptosis and lidocaine
9) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.48 Pain Relevance 0.77
PMN and mononuclear cells) present in the peritoneal exudates during the initial phase of inflammation (4 h after zymosan, 11.8±0.4×106 leukocytes), with a maximal infiltration at 12 h (30.0±2.5×106 leukocytes), followed by a decline or resolution as monitored to 72 h.
Gene_expression (mononuclear cells) of PMN in leukocytes associated with inflammation
10) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.70 Pain Relevance 0.69
Lidocaine impairs PMN apoptosis and their removal by macrophages
Gene_expression (apoptosis) of PMN in macrophages associated with apoptosis and lidocaine
11) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.44 Pain Relevance 0.94
The increase in exudate PMN was ?
Gene_expression (exudate) of PMN
12) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.34 Pain Relevance 0.66
PMN and mononuclear cells) present in the peritoneal exudates during the initial phase of inflammation (4 h after zymosan, 11.8±0.4×106 leukocytes), with a maximal infiltration at 12 h (30.0±2.5×106 leukocytes), followed by a decline or resolution as monitored to 72 h.
Gene_expression (present) of PMN in leukocytes associated with inflammation
13) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.70 Pain Relevance 0.75
In addition, PMN are found in white layers of thrombin where they may interact with platelets to attract more of each.
Gene_expression (found) of PMN in platelets
14) Confidence 0.05 Published 1993 Journal Haemostasis Section Abstract Doc Link 8495864 Disease Relevance 0.58 Pain Relevance 0.17
In lidocaine-treated animals PMN CD11b expression was maintained at basal levels 2 hours after reperfusion, compared with group II, in which upregulation of CD11b was observed.
Gene_expression (expression) of PMN
15) Confidence 0.03 Published 1996 Journal Ann. Thorac. Surg. Section Body Doc Link 8619724 Disease Relevance 0 Pain Relevance 0
Peripheral blood PMN CD11b expression was determined by flow cytometry.
Gene_expression (expression) of PMN in blood
16) Confidence 0.03 Published 1996 Journal Ann. Thorac. Surg. Section Body Doc Link 8619724 Disease Relevance 0.15 Pain Relevance 0
Granulocyte colony-stimulating factor (G-CSF) is the cytokine that is critical for polymorphonuclear neutrophilic granulocyte (PMN) production as well as being a potent agonist of PMN activation.
Gene_expression (production) of PMN in Granulocyte associated with agonist and cytokine
17) Confidence 0.01 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.46 Pain Relevance 0.13
C. gattii cells with extracellular fibrils were also significantly more resistant to killing by human polymorphonuclear neutrophils (PMN) in vitro even though these PMN produced elaborate neutrophil extracellular traps (NETs).
Gene_expression (produced) of PMN in PMN associated with tumor necrosis factor receptor-associated periodic syndrome
18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2881863 Disease Relevance 0.29 Pain Relevance 0
The different mechanisms by which PMA and cytokines activate PMNs produced different levels of hydrogen peroxide in PMN culture, demonstrating that PMNs stimulated with PMA generated higher levels of hydrogen peroxide than those stimulated with TNF-?
Gene_expression (produced) of PMN associated with cytokine
19) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.06 Pain Relevance 0.18
Our data confirm C3 expression by PMNs in culture, and demonstrate the expression of C1q and C4 by PMNs, providing a more complete characterization of PMN expression of the early complement proteins in culture.
Gene_expression (expression) of PMN
20) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2443364 Disease Relevance 0.44 Pain Relevance 0.19

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