INT42727

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Context Info
Confidence 0.14
First Reported 1982
Last Reported 1982
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 2.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1, Trim13) signal transducer activity (Oprm1, Trim13) endoplasmic reticulum (Trim13)
intracellular (Trim13) plasma membrane (Oprm1) ligase activity (Trim13)
Oprm1 (Mus musculus)
Trim13 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Morphine 3 100.00 Very High Very High Very High
Potency 2 99.74 Very High Very High Very High
Analgesic 6 99.58 Very High Very High Very High
analgesia 8 98.86 Very High Very High Very High
Opioid 5 93.04 High High
tail-flick 1 85.60 High High
agonist 1 55.12 Quite High
antagonist 1 50.08 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Assuming mu receptor mediation of analgesia, there is an affinity and analgesic potency (ie: D-Ala2-Leu5-enkephalin has 1/7 the affinity of morphine for the mu receptor but is 18X more potent as an analgesic).
mu receptor Binding (affinity) of Leu5 associated with analgesic, enkephalin, morphine, potency and analgesia
1) Confidence 0.14 Published 1982 Journal Life Sci. Section Abstract Doc Link 6283293 Disease Relevance 0 Pain Relevance 2.54

General Comments

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