INT42799

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Context Info
Confidence 0.69
First Reported 1982
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.10
Pain Relevance 5.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
nucleus accumbens 3
lymphocytes 2
substantia nigra pars reticulata 1
neurons 1
brain 1
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 25 100.00 Very High Very High Very High
dopamine receptor 6 100.00 Very High Very High Very High
analgesia 11 99.84 Very High Very High Very High
Nucleus accumbens 6 99.68 Very High Very High Very High
Migraine 8 99.64 Very High Very High Very High
Enkephalin 13 98.44 Very High Very High Very High
agonist 6 98.20 Very High Very High Very High
cocaine 9 97.98 Very High Very High Very High
Dynorphin 2 97.44 Very High Very High Very High
substance P 2 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 8 99.64 Very High Very High Very High
Recurrence 3 88.80 High High
Hypersensitivity 2 86.64 High High
Stress 2 84.04 Quite High
Opiate Addiction 1 49.60 Quite Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute cocaine produced a transient increase in BDNF mRNA in the prefrontal cortex, associated with a long-lasting increase in drd3 mRNA, and a delayed and long-lasting increase in Drd3 protein in the nucleus accumbens.
Positive_regulation (increase) of drd3 in nucleus accumbens associated with nucleus accumbens and cocaine
1) Confidence 0.69 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671872 Disease Relevance 0.09 Pain Relevance 0.39
Acute cocaine produced a transient increase in BDNF mRNA in the prefrontal cortex, associated with a long-lasting increase in drd3 mRNA, and a delayed and long-lasting increase in Drd3 protein in the nucleus accumbens.
Positive_regulation (increase) of Drd3 protein in nucleus accumbens associated with nucleus accumbens and cocaine
2) Confidence 0.69 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671872 Disease Relevance 0.09 Pain Relevance 0.40
In agreement, induction of D3 receptor binding sites was evidenced, using 7-[3H]hydroxy-N,N-di-propyl-2-aminotetralin ([3H]7-OH-DPAT), in substantia nigra pars reticulata, the projection area of the direct nigrostriatonigral pathway.
Positive_regulation (induction) of D3 receptor in substantia nigra pars reticulata associated with substantia nigra
3) Confidence 0.69 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886351 Disease Relevance 0 Pain Relevance 0.19
Using double in situ hybridization techniques, we show that D3 receptor mRNA induction after repeated administration of levodopa took place mainly in dynorphin/substance P-expressing neurons of the direct striatonigral pathway.
Positive_regulation (induction) of D3 receptor in neurons associated with dynorphin and substance p
4) Confidence 0.69 Published 2000 Journal Eur. J. Neurosci. Section Abstract Doc Link 10886351 Disease Relevance 0 Pain Relevance 0.18
Abused drugs increase acutely BDNF expression, which leads to subsequent long-lasting elevation of Drd3 in the nucleus accumbens that may facilitate responding to drug-associated stimuli.
Positive_regulation (elevation) of Drd3 in nucleus accumbens associated with nucleus accumbens
5) Confidence 0.47 Published 2005 Journal Neuroreport Section Abstract Doc Link 15671872 Disease Relevance 0.08 Pain Relevance 0.39
CONCLUSIONS: This study shows that maternal deprivation and handling induced a prolonged morphine CPP, and different changes of D2/D3 receptor functioning revealed after morphine CPP.
Positive_regulation (changes) of D3 receptor
6) Confidence 0.45 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17492273 Disease Relevance 0 Pain Relevance 0
Migraine patients show an increased density of dopamine D3 and D4 receptors on lymphocytes.
Positive_regulation (increased) of dopamine D3 in lymphocytes associated with dopamine and migraine
7) Confidence 0.42 Published 2000 Journal Cephalalgia Section Title Doc Link 10817442 Disease Relevance 0.35 Pain Relevance 0.64
An increased density of both DRD3 (P=0.0006) and DRD4 (P=0.002) on PBL was observed in migraineurs compared with controls.
Positive_regulation (increased) of DRD3 in PBL
8) Confidence 0.42 Published 2000 Journal Cephalalgia Section Abstract Doc Link 10817442 Disease Relevance 0.34 Pain Relevance 0.63
Elevated D3 dopamine receptor mRNA in dopaminergic and dopaminoceptive regions of the rat brain in response to morphine.
Positive_regulation (Elevated) of D3 dopamine receptor mRNA in brain associated with dopamine receptor and morphine
9) Confidence 0.35 Published 2003 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12654507 Disease Relevance 0 Pain Relevance 0.79
Blockade of dopaminergic receptors reduced SIA, while induction of dopaminergic receptor supersensitivity failed to affect footshock-induced analgesia.
Positive_regulation (induction) of dopaminergic receptor associated with analgesia
10) Confidence 0.29 Published 1982 Journal J. Neural Transm. Section Abstract Doc Link 6286868 Disease Relevance 0.16 Pain Relevance 1.29
Our data provide direct evidence for a dopaminergic inhibitory control on enkephalin biosynthesis and secretion from striatal cell cultures, mediated through the dopaminergic D2 receptor activation.
Positive_regulation (activation) of dopaminergic D2 receptor associated with enkephalin
11) Confidence 0.21 Published 1993 Journal Neuroscience Section Abstract Doc Link 8487949 Disease Relevance 0 Pain Relevance 1.03

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