INT42810

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Context Info
Confidence 0.77
First Reported 1982
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 53
Total Number 56
Disease Relevance 10.87
Pain Relevance 15.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein transporter activity (CALCRL) endosome (CALCRL) endoplasmic reticulum (CALCRL)
plasma membrane (CALCRL) lysosome (CALCRL) signal transducer activity (CALCRL)
Anatomy Link Frequency
chondrocyte 2
plasma 1
macrophages 1
brain 1
oocytes 1
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 171 100.00 Very High Very High Very High
Opioid 64 100.00 Very High Very High Very High
Enkephalin 55 100.00 Very High Very High Very High
Pain 37 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 100.00 Very High Very High Very High
Sumatriptan 12 99.84 Very High Very High Very High
Morphine 93 99.48 Very High Very High Very High
Migraine 9 99.38 Very High Very High Very High
agonist 365 99.26 Very High Very High Very High
potassium channel 1 98.86 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 34 100.00 Very High Very High Very High
Pancreatic Cancer 27 99.84 Very High Very High Very High
Glioma 5 99.72 Very High Very High Very High
Malignant Neoplastic Disease 14 99.40 Very High Very High Very High
Headache 9 99.38 Very High Very High Very High
Adenocarcinoma 22 98.92 Very High Very High Very High
Experimental Melanoma 2 98.88 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.20 Very High Very High Very High
Neuroblastoma 22 97.84 Very High Very High Very High
Coronary Artery Disease 2 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Calcitonin gene-related peptide receptor expression in alternatively activated monocytes/macrophages during irreversible pulpitis.
Gene_expression (expression) of Calcitonin gene-related peptide receptor in monocytes associated with pulpitis and calcitonin gene-related peptide
1) Confidence 0.77 Published 2008 Journal J Endod Section Title Doc Link 18634925 Disease Relevance 0.51 Pain Relevance 0.57
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
Gene_expression (expression) of CRLR associated with neuropeptide
2) Confidence 0.77 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.22
All 5 evaluated pancreatic cancer cells lines expressed ADM, CRLR, RAMP1 and RAMP2, whereas RAMP3 was expressed in only 1/5 pancreatic cancer cell lines.
Gene_expression (expressed) of CRLR associated with pancreatic cancer
3) Confidence 0.72 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.61 Pain Relevance 0.27
By immunohistochemistry, ADM, CRLR, RAMP1 and RAMP2, but not RAMP3, were expressed in pancreatic cancer cells.
Gene_expression (expressed) of CRLR associated with pancreatic cancer
4) Confidence 0.72 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 1.13 Pain Relevance 0.25
CRLR combined with RAMP binds calcitonin gene-related peptide with high affinity, whereas CRLR coexpression with RAMP2 or -3 confers high-affinity binding of adrenomedullin.
Gene_expression (coexpression) of CRLR associated with calcitonin gene-related peptide
5) Confidence 0.67 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.21
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
Spec (determined) Gene_expression (coexpression) of receptor associated with neuropeptide
6) Confidence 0.58 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.22
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
Gene_expression (expression) of receptor associated with neuropeptide
7) Confidence 0.58 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.22
Central to functional binding of these neuropeptides is the G-protein-coupled receptor, the calcitonin receptor-like receptor (CRLR), whose cell surface expression and pharmacology is determined by coexpression of a receptor activity-modifying protein (RAMP).
Spec (determined) Gene_expression (coexpression) of receptor associated with neuropeptide
8) Confidence 0.52 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.22
The authors investigated the expression of these receptor components in human cerebral vasculature to further characterize neuropeptide receptor content and the potential functions of these receptors.
Spec (investigated) Gene_expression (expression) of receptor in vasculature associated with neuropeptide
9) Confidence 0.52 Published 2002 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 11973435 Disease Relevance 0 Pain Relevance 0.24
By QRT-PCR, median mRNA levels of ADM and CRLR were 1.5- and 2.4-fold higher, respectively, in PDAC tissues compared to normal pancreatic tissues.
Gene_expression (levels) of CRLR associated with adenocarcinoma
10) Confidence 0.49 Published 2007 Journal Int. J. Cancer Section Abstract Doc Link 17290391 Disease Relevance 0.93 Pain Relevance 0.21
The equilibrium dissociation constant of the radioligand [(3)H]GR 125743 was similar for both chimera compared to the wild-type (wt) h 5-HT(1B) receptor upon transient expression in COS-7 cells.
Gene_expression (expression) of receptor
11) Confidence 0.45 Published 2000 Journal Biochem. Pharmacol. Section Abstract Doc Link 10704941 Disease Relevance 0 Pain Relevance 0.11
Calcitonin gene-related peptide receptor expression in alternatively activated monocytes/macrophages during irreversible pulpitis.
Gene_expression (expression) of Calcitonin gene-related peptide receptor in macrophages associated with pulpitis and calcitonin gene-related peptide
12) Confidence 0.26 Published 2008 Journal J Endod Section Title Doc Link 18634925 Disease Relevance 0.51 Pain Relevance 0.57
Maximal activity for both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and Ac-RYYRIK-NH(2) was significantly greater in cells transfected with the human receptor (90% and 73% in a high expressing clone, 76% and 68% in low expressing clone) rather than the mouse receptor (37.5 and 33%), regardless of receptor number in individual clones.
Gene_expression (transfected) of receptor
13) Confidence 0.07 Published 2000 Journal Peptides Section Abstract Doc Link 10998550 Disease Relevance 0 Pain Relevance 0.33
Maximal activity for both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and Ac-RYYRIK-NH(2) was significantly greater in cells transfected with the human receptor (90% and 73% in a high expressing clone, 76% and 68% in low expressing clone) rather than the mouse receptor (37.5 and 33%), regardless of receptor number in individual clones.
Gene_expression (expressing) of receptor
14) Confidence 0.07 Published 2000 Journal Peptides Section Abstract Doc Link 10998550 Disease Relevance 0 Pain Relevance 0.33
Conserved expression of the opioid growth factor, [Met5]enkephalin, and the zeta (zeta) opioid receptor in vertebrate cornea.
Gene_expression (expression) of receptor in cornea associated with opioid receptor, enkephalin and opioid
15) Confidence 0.05 Published 1995 Journal Brain Res. Section Title Doc Link 7728521 Disease Relevance 0 Pain Relevance 0.73
Nonpeptide ligands of either receptor subtype produced by several industrial organizations often possess significant structural commonalities that can lead to the definition of a pharmacophore, especially when the receptor docking models are compared.
Gene_expression (produced) of receptor
16) Confidence 0.04 Published 2006 Journal Curr Top Med Chem Section Abstract Doc Link 16918454 Disease Relevance 0.33 Pain Relevance 0.26
While the B(2)receptor subtype, constitutively expressed in various tissues, is believed to mediate most of the physiological actions of kinins in healthy conditions, the B(1) receptor, highly regulated during inflammation, has been associated with the sustained actions of these peptides in various pathological situations.
Gene_expression (expressed) of receptor associated with inflammation
17) Confidence 0.04 Published 2006 Journal Curr Top Med Chem Section Abstract Doc Link 16918454 Disease Relevance 0.20 Pain Relevance 0.17
Lineage specific gene expansions have long been observed in several cases including that of the opsin and fish odorant receptor expansions in puffer fish [6] and trace amine receptor expansion in zebrafish [42].
Gene_expression (expansion) of receptor
18) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0.06
Lineage specific gene expansions have long been observed in several cases including that of the opsin and fish odorant receptor expansions in puffer fish [6] and trace amine receptor expansion in zebrafish [42].
Gene_expression (expansions) of receptor
19) Confidence 0.03 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0 Pain Relevance 0.06
On the basis of these data, a working hypothesis has been formulated which postulates that distinct morphine and enkephalin receptors coexist in an opioid-receptor complex.
Gene_expression (coexist) of receptor associated with enkephalin, opioid and morphine
20) Confidence 0.03 Published 1982 Journal Mol. Pharmacol. Section Abstract Doc Link 6287193 Disease Relevance 0 Pain Relevance 1.49

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