INT42819

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Context Info
Confidence 0.40
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.07
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ina) structural molecule activity (Ina)
Anatomy Link Frequency
NZs 2
Ina (Rattus norvegicus)
Pain Link Frequency Relevance Heat
halothane 4 99.84 Very High Very High Very High
isoflurane 4 98.28 Very High Very High Very High
lidocaine 6 97.34 Very High Very High Very High
potassium channel 3 75.00 Quite High
addiction 2 70.68 Quite High
sodium channel 4 69.84 Quite High
Action potential 17 51.56 Quite High
depression 1 48.96 Quite Low
anesthesia 1 46.68 Quite Low
antiarrhythmic agent 1 43.84 Quite Low
Disease Link Frequency Relevance Heat
Depression 2 66.84 Quite High
Arrhythmia Under Development 1 45.64 Quite Low
Infarction 1 38.32 Quite Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of INa can be greatly increased by repetitive membrane depolarization.
Positive_regulation (increased) of Negative_regulation (Inhibition) of INa
1) Confidence 0.40 Published 1982 Journal Neirofiziologiia Section Abstract Doc Link 6287317 Disease Relevance 0 Pain Relevance 0.10
At approximately equianesthetic concentrations, the decrease of INa caused by halothane was twice that observed with isoflurane or sevoflurane.
Positive_regulation (caused) of Negative_regulation (decrease) of INa associated with isoflurane and halothane
2) Confidence 0.40 Published 1997 Journal Anesth. Analg. Section Abstract Doc Link 9024016 Disease Relevance 0.07 Pain Relevance 0.32
In both IZs and NZs, lidocaine (20 to 120 micromol/L) accelerated the rate of time-dependent loss of availability and markedly delayed recovery from availability, inducing significant use-dependent reduction of INa.
Positive_regulation (inducing) of Negative_regulation (reduction) of INa in NZs associated with lidocaine
3) Confidence 0.22 Published 1998 Journal Circ. Res. Section Abstract Doc Link 9721700 Disease Relevance 0 Pain Relevance 0.50
All three compounds reduced INa amplitude (Figure 7A–7C), with CQ causing an especially pronounced reduction in INa (to 29.09%±1.07% of baseline).
Positive_regulation (causing) of Negative_regulation (reduction) of INa
4) Confidence 0.06 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2741594 Disease Relevance 0 Pain Relevance 0

General Comments

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