INT4282

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 2008
Negated 4
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.51
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Msr1) plasma membrane (Msr1)
Anatomy Link Frequency
sciatic nerve 1
spinal cord 1
semitendinosus 1
vas deferens 1
Msr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
Cannabinoid receptor 6 100.00 Very High Very High Very High
Cannabinoid 5 100.00 Very High Very High Very High
Somatostatin 4 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
fluoxetine 6 99.84 Very High Very High Very High
Spinal cord 14 99.68 Very High Very High Very High
Locus ceruleus 14 99.68 Very High Very High Very High
narcan 6 99.60 Very High Very High Very High
Demyelination 1 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 2 99.80 Very High Very High Very High
Cancer 2 98.72 Very High Very High Very High
Demyelinating Disease 1 98.56 Very High Very High Very High
Depression 3 98.54 Very High Very High Very High
Anxiety Disorder 6 98.24 Very High Very High Very High
Injury 3 96.52 Very High Very High Very High
Pituitary Cancer 4 93.16 High High
Pain 3 92.80 High High
Drug Dependence 1 92.12 High High
Cognitive Disorder 2 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of semicarbazide at 200 mg/kg, i.v. did not influence the increasing effect of aminopyrine on MSR and PSR.
Regulation (effect) of MSR
1) Confidence 0.45 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.19
The amplitude of DRR decreased by aminopyrine was reversed by diazepam at 0.2 mg/kg, i.v.; however, the increased amplitudes of MSR and PSR were not affected by diazepam.
Neg (not) Regulation (affected) of MSR
2) Confidence 0.45 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.19
Antagonism studies using pharmacological tools targeting a variety of neurotransmitters involved in anxiety and depression and the use of mice lacking the beta3 adrenoceptor suggested that these effects of SR58611A are mediated by beta3 adrenoceptors.
Regulation (effects) of SR58611A associated with neurotransmitter, depression and anxiety disorder
3) Confidence 0.32 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 17460614 Disease Relevance 0.93 Pain Relevance 0.46
This inhibition of the flexor (posterior biceps-semitendinosus) MSR was not altered by fluoxetine.
Neg (not) Regulation (altered) of MSR in semitendinosus associated with fluoxetine
4) Confidence 0.23 Published 1976 Journal Brain Res. Section Abstract Doc Link 1086701 Disease Relevance 0 Pain Relevance 0.45
Pretreatment of semicarbazide at 200 mg/kg, i.v. did not influence the increasing effect of aminopyrine on MSR and PSR.
Neg (not) Regulation (influence) of MSR
5) Confidence 0.20 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.19
Methysergide at 1 mg/kg, i.v. antagonized this increasing effect of aminopyrine on MSR and PSR.
Regulation (effect) of MSR
6) Confidence 0.20 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1464397 Disease Relevance 0 Pain Relevance 0.25
However, systemic naloxone had no significant effect on the unconditioned MSR of the spinal cord.
Neg (no) Regulation (effect) of MSR in spinal cord associated with narcan and spinal cord
7) Confidence 0.11 Published 1993 Journal Neuropharmacology Section Abstract Doc Link 8361578 Disease Relevance 0 Pain Relevance 0.52
Selective blockade of alpha 1-adrenoceptors by pretreatment with prazosin-HCl abolished these facilitatory effects on the MSR and the PSR and revealed the inhibitory effect of L-dopa on the PSR.
Regulation (effects) of MSR
8) Confidence 0.04 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 2177121 Disease Relevance 0.09 Pain Relevance 0.35
Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.
Regulation (Effect) of SR141716 in sciatic nerve associated with nociception, pain, demyelination, eae, antagonist, cannabinoid, injury and sciatic nerve
9) Confidence 0.03 Published 2005 Journal Pain Section Title Doc Link 15936882 Disease Relevance 1.05 Pain Relevance 1.26
The present study was performed to evaluate the effects of a slow release formulation of the somatostatin analog lanreotide (SR-L) on both hormone secretion and tumor size and to assess the tolerance in a series of thyrotropinomas treated for 6 months.
Regulation (effects) of SR-L associated with cancer, tolerance and somatostatin
10) Confidence 0.03 Published 2000 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10770186 Disease Relevance 0.44 Pain Relevance 0.22
Kd values of the selective CB1 cannabinoid receptor antagonist, SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1 H-pyrazole-3-carboxamide hydrochloride], determined in the vas deferens from experiments with these compounds are 1.34 nM, 3.86 nM and 8.06 nM respectively, indicating their susceptibility to antagonism by SR141716A is similar to that of their parent compound, the CB1 cannabinoid receptor agonist WIN 55,212-2 ¿(R)-(+)-[2,3-dihydro-5-methyl-3-[4-methylino)methyl]pyrrolo-[1,2, 3-de]-1,4-benzoxazin-6-yl](1-naphthyl)methanone}.
Spec (determined) Regulation (values) of SR141716A in vas deferens associated with cannabinoid receptor, antagonist and agonist
11) Confidence 0.02 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8666005 Disease Relevance 0 Pain Relevance 0.42
Electrical stimulation of the LC has a biphasic effect on MSR amplitude, facilitation followed by inhibition.
Regulation (effect) of MSR associated with locus ceruleus
12) Confidence 0.02 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7859099 Disease Relevance 0 Pain Relevance 1.25

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