INT4283

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Context Info
Confidence 0.46
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.85
Pain Relevance 4.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbs) lyase activity (Cbs) nucleolus (Cbs)
nucleus (Cbs) enzyme binding (Cbs) cytoplasm (Cbs)
Anatomy Link Frequency
neurons 2
visceral 1
colon 1
nociceptor 1
heart 1
Cbs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 124 99.62 Very High Very High Very High
spastic colon 40 99.24 Very High Very High Very High
nociceptor 6 99.04 Very High Very High Very High
Inflammation 45 98.96 Very High Very High Very High
Angina 7 98.96 Very High Very High Very High
nud 89 98.56 Very High Very High Very High
Pain 49 98.12 Very High Very High Very High
Neuropeptide 1 95.76 Very High Very High Very High
calcitonin gene related peptide 8 94.64 High High
Cannabinoid 46 94.04 High High
Disease Link Frequency Relevance Heat
Dermatitis 1 99.80 Very High Very High Very High
Ganglion Cysts 125 99.62 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

32 99.24 Very High Very High Very High
INFLAMMATION 46 98.96 Very High Very High Very High
Cv General 3 Under Development 5 98.96 Very High Very High Very High
Hypoxia 16 98.92 Very High Very High Very High
Hypersensitivity 1 98.70 Very High Very High Very High
Dyspepsia 89 98.56 Very High Very High Very High
Pain 57 98.12 Very High Very High Very High
Pruritus 1 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-synthase (CBS) is expressed by a subpopulation of primary sensory neurons (Figs. 1, 2 &3) and is upregulated in a rat model of IBS-like chronic visceral hyperalgesia (Fig. 4).
Positive_regulation (upregulated) of CBS in visceral associated with spastic colon and nud
1) Confidence 0.46 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.69 Pain Relevance 0.73
All colon specific DRG neurons that were immunoreactive for CBS also were positive for TRPV1 (Fig. 2C, E&2F).
Positive_regulation (immunoreactive) of CBS in colon associated with dorsal root ganglion
2) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.11 Pain Relevance 0.51
The H2S-producing enzyme CBS is expressed by colonic specific DRG neurons
Positive_regulation (enzyme) of CBS in neurons associated with dorsal root ganglion
3) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.29 Pain Relevance 0.12
Similarly, all colon specific DRG neurons that were immunoreactive for CBS also were positive for P2X3R (Fig. 3C, E&3F).


Positive_regulation (immunoreactive) of CBS in neurons associated with dorsal root ganglion
4) Confidence 0.43 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.04 Pain Relevance 0.48
Immunoblot assays demonstrated the presence of Na(v)alpha-subunit (c. 220 kDa) in crude homogenates from rat CBs, being evident an up-regulation (60%) of this protein in the CBs obtained from chronically hypoxic rats (10% O2; 7 days).
Positive_regulation (up-regulation) of CBs associated with hypoxia
5) Confidence 0.42 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17564680 Disease Relevance 0.49 Pain Relevance 0.54
With 10 micrograms/ml and 100 micrograms/ml CBS, basal amylase secretion was increased in a dose-dependent manner, by 13.7 +/- 11.7% (P < 0.05) and 24.5 +/- 12.8% (P < 0.01).
Positive_regulation (increased) of CBS
6) Confidence 0.39 Published 1992 Journal Res Exp Med (Berl) Section Abstract Doc Link 1282729 Disease Relevance 0.37 Pain Relevance 0.07
Immunoblot assays demonstrated the presence of Na(v)alpha-subunit (c. 220 kDa) in crude homogenates from rat CBs, being evident an up-regulation (60%) of this protein in the CBs obtained from chronically hypoxic rats (10% O2; 7 days).
Positive_regulation (up-regulation) of CBs associated with hypoxia
7) Confidence 0.37 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17564680 Disease Relevance 0.49 Pain Relevance 0.54
Three hundred and twenty-two patients with non-stable stenocardia were divided into two groups: group one consisted of 226 patients with mono-, bi-, or tri-vascular lesion of the coronary arteries (CA), who underwent percutaneous coronary intervention (PCCI) on the symptom-related CA (128 patients) or coronary bypass surgery (CBS) without cardiopulmonary bypass (59 patients); group two consisted of 96 patients with tri-vascular lesion of CA only, who underwent CBS with cardiopulmonary bypass (CPB) (32 patients) or without CPB (52 patients).
Positive_regulation (underwent) of CBS associated with angina
8) Confidence 0.22 Published 2007 Journal Klin Med (Mosk) Section Abstract Doc Link 17665601 Disease Relevance 0.36 Pain Relevance 0.17
After CBS all 15 patients had increased physical activity before angina or completion of treadmill exercise with increased heart rate-blood pressure product (HRBP) (+ 63 +/- 3.2 X 10(2) bpm - mm Hg) in 14 of 15 patients indicating increased CBF; four had positive TECG, and five had EA.
Positive_regulation (increased) of CBS in heart associated with heart rate under development and angina
9) Confidence 0.11 Published 1976 Journal Circulation Section Abstract Doc Link 1086743 Disease Relevance 0.55 Pain Relevance 0.48
9-THC reduced allergic inflammation in mouse ear model of allergic dermatitis.[51] The activation of cutaneous CBs lead to attenuation of nociceptor excitation, pain and itch perception,[52] and decreased the release of neuropeptides, particularly CGRP, from terminal afferents
Positive_regulation (activation) of CBs in nociceptor associated with pain, hypersensitivity, dermatitis, calcitonin gene related peptide, inflammation, nociceptor, neuropeptide and pruritus
10) Confidence 0.05 Published 2010 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2878434 Disease Relevance 1.29 Pain Relevance 0.81

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